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Researchers to explore genomes of childhood cancers

In a project supported by Genome BC, a Vancouver pediatric pathologist at the BC Cancer Agency/University of British Columbia is leading the team that will explore the genomes of four of the most challenging childhood cancers known.

23 Feb 2011

Mutated cancer pathway studies identify therapeutic targets for congenital heart disease

Cross-disciplinary teams of scientists studying genetic pathways that are mutated in many forms of cancer, but which also cause certain forms of congenital heart disease - including hypertrophic cardiomyopathy, a thickening of the heart muscle that is the leading cause of sudden death in children and young adults -, have introduced these mutations into mice and successfully treated HCM in the lab.

22 Feb 2011

New study: Rapamycin reverses cardiac muscle damage in LEOPARD syndrome mouse model

Congenital heart diseases affect approximately one in 100 patients, making them the most common type of birth defect and the number-one cause of pediatric deaths.

21 Feb 2011

Scientists identify new cellular mechanism underlying hydronephrosis

One of the most common congenital defects in humans - it is detected in approximately 0.5% of fetuses analyzed by routine antenatal sonography - is a kidney abnormality known as hydronephrosis. Hydronephrosis arises because the flow of urine from the kidney to the bladder is impeded.

21 Feb 2011

International study shows reprogramming cells lead to genomic aberrations

It's a discordant note in the symphony of good news that usually accompanies stem cell research announcements. Stem cells hold enormous promise in regenerative medicine, thanks to their ability to regenerate diseased or damaged tissues.

21 Feb 2011

A special type of Dwarfism protects against cancer & diabetes: Study

Researchers have found that some individuals living in remote villages in Ecuador have a mutation that could throw light on human longevity and ways to increase it. These villagers, all dwarfs with heights less than three and a half feet, have a rare condition called Laron syndrome or Laron dwarfism.

20 Feb 2011

Predictive to present results on development of real-time multiplexed PCR FGFR3 assay at ASCO 2011

Predictive Biosciences today announced that the Company will be presenting results on the development of a real-time multiplexed PCR assay for detection of FGFR3 mutations in urine and tissue at the American Society of Clinical Oncology (ASCO) 2011 Genitourinary Cancers Symposium being held February 17 - 19 in Orlando, Florida. Results will also focus on the application of the assay which is currently being used in Predictive's first commercial molecular grading product, the CertNDxTM Molecular Grading Assay.

19 Feb 2011

Biologist investigates CAPV-EAE population for hereditary breast and ovary cancer

Between 5 % and 10 % of breast cancer cases are hereditary, arising because the patient inherits from the father or mother a mutation in a gene that is susceptible to causing the illness. BRCA1 and BRCA2 have already been identified as two of the genes to be monitored. It is estimated that 30 % of hereditary breast cancer cases are due to mutations in one of these two genes.

19 Feb 2011

Scientists establish biomarker strategy to diagnose variety of cancer types

A team of biologists, clinical oncologists, pathologists and information scientists has established a strategy for identifying biomarkers. If a particular pattern of these biomarkers can be detected in the blood, this indicates a cancerous disease. An interdisciplinary research breakthrough that opens many doors.

18 Feb 2011

Two researchers receive Brupbacher Prize for Cancer Research 2011

Today, the Charles Rodolphe Brupbacher Prize for Cancer Research 2011 goes to two researchers who have contributed to better understanding of the genetics underlying the growth of tumors.

17 Feb 2011

Metallic copper surfaces kill bacteria on contact

Metallic copper surfaces kill microbes on contact, decimating their populations, according to a paper in the February 2011 issue of the journal Applied and Environmental Microbiology. They do so literally in minutes, by causing massive membrane damage after about a minute's exposure, says the study's corresponding author, Gregor Grass of the University of Nebraska, Lincoln. This is the first study to demonstrate this mechanism of bacteriocide.

17 Feb 2011

Mutations in gene linked to structure of the heart seen in Ebstein's anomaly patients

Ebstein's anomaly is a rare congenital valvular heart disease. Now, in patients with this disease, researchers of the Academic Medical Center Amsterdam in the Netherlands, the University of Newcastle, UK and the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have identified mutations in a gene which plays an important role in the structure of the heart.

16 Feb 2011

Break-induced Replication more likely to cause genetic mutation than normal cell repair

Researchers from Indiana University-Purdue University Indianapolis and Umea- University report in a study published in the February 15, 2011, issue of PLoS Biology that a method by which cells repair breaks in their DNA, known as Break-induced Replication, is up to 2,800 times more likely to cause genetic mutation than normal cell repair.

16 Feb 2011

Research: Whole genome sequencing on tumors can treat pancreatic cancer

Whole genome sequencing - spelling out a person's entire DNA genetic code - has moved one step closer to being a medical option for direct patient care.

16 Feb 2011

Researchers identify cell of origin for sarcoma

Researchers at Oregon Health & Science University Doernbecher Children's Hospital have defined the cell of origin for a kind of cancer called sarcoma. In a study published today as the Featured Article in the journal Cancer Cell, they report that childhood and adult sarcomas are linked in their biology, mutations and the cells from which these tumors first start.

16 Feb 2011

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

In cancer and other pathological diseases, researchers are discovering that packaging is important: specifically, how DNA - about two meters long when unwound and stretched - coils up and compacts neatly inside the nucleus of a cell.

15 Feb 2011

Study: Active wound healing can lead to increased risk of basal cell carcinoma in skin

Processes that are involved in active wound healing can lead to an increased risk for basal cell carcinoma in the skin. This is the conclusion of a recent study from the Swedish medical university Karolinska Institutet, published in the journal PNAS.

15 Feb 2011

Screening breast MRIs can detect invasive cancers in women with history of chest irradiation

Breast cancer screening with MRI can detect invasive cancers missed on mammography in women who've undergone chest irradiation for other diseases, according to a new study published online and in the April print edition of Radiology.

15 Feb 2011

NHGRI's new strategic plan to identify genetic bases of most single-gene disorders

A new strategic plan from an arm of the National Institutes of Health envisions scientists being able to identify genetic bases of most single-gene disorders and gaining new insights into multi-gene disorders in the next decade. This should lead to more accurate diagnoses, new drug targets and the development of practical treatments for many who today lack therapeutic options, according to the plan from the National Human Genome Research Institute (NHGRI).

14 Feb 2011

New study on mosquito genome sequences to identify 'transposable elements'

A team of scientists at the University of California, Riverside has begun working on a mosquito research project that, if successful, will provide valuable genetic resources capable of transforming the way mosquito research is conducted around the world.

14 Feb 2011

Mutation News and Research

Researchers to explore genomes of childhood cancers

Mutated cancer pathway studies identify therapeutic targets for congenital heart disease

New study: Rapamycin reverses cardiac muscle damage in LEOPARD syndrome mouse model

Scientists identify new cellular mechanism underlying hydronephrosis

International study shows reprogramming cells lead to genomic aberrations

A special type of Dwarfism protects against cancer & diabetes: Study

Predictive to present results on development of real-time multiplexed PCR FGFR3 assay at ASCO 2011

Biologist investigates CAPV-EAE population for hereditary breast and ovary cancer

Scientists establish biomarker strategy to diagnose variety of cancer types

Two researchers receive Brupbacher Prize for Cancer Research 2011

Metallic copper surfaces kill bacteria on contact

Mutations in gene linked to structure of the heart seen in Ebstein's anomaly patients

Break-induced Replication more likely to cause genetic mutation than normal cell repair

Research: Whole genome sequencing on tumors can treat pancreatic cancer

Researchers identify cell of origin for sarcoma

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

Study: Active wound healing can lead to increased risk of basal cell carcinoma in skin

Screening breast MRIs can detect invasive cancers in women with history of chest irradiation

NHGRI's new strategic plan to identify genetic bases of most single-gene disorders

New study on mosquito genome sequences to identify 'transposable elements'

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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