Protein C News and Research

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Structure of SARS-CoV-2 spike protein postfusion

A new study published in PNAS proposes a higher resolution in situ structure of the SARS-CoV-2 spike protein in its postfusion state.

18 Nov 2021

Blood proteomic survey in undiagnosed population with COVID-19

In this study, scientists have profiled 276 circulating proteins that are associated with cardiovascular and metabolic functions.

18 Nov 2021

Real-world effectiveness and safety of COVID-19 vaccines

A new study published in Infectious Diseases of Poverty aimed to systematically evaluate the effectiveness and safety of the COVID-19 vaccines in the real world as well as establish a reliable evidence-based basis to determine the actual protective effect of the COVID-19 vaccines, especially considering the new waves of infection brought about by the variants.

18 Nov 2021

Toll-like receptor 2 - novel target for improved COVID-19 vaccines

In a new study, researchers from French and American institutes analyzed at a molecular level the interaction between SARS-CoV-2 E protein and human TLR2.

17 Nov 2021

Study shows neutralizing capacity of monoclonal antibodies against SARS-CoV-2 variants of concern

Canadian public health researchers recently published a study in the journal Antiviral Research wherein they described generating a panel of murine hybridomas recognizing SARS-CoV-2 spike protein or nucleoprotein, capable of neutralizing the SARS-CoV-2 variants of concern, proving their therapeutic potential.

17 Nov 2021

Study leverages the DIAAS system to understand protein quality in meat burgers and plant-based burgers

A new study from the University of Illinois and Colorado State University leverages the DIAAS system to understand protein quality in beef and pork burgers and plant-based burgers from Impossible and Beyond Meat.

17 Nov 2021

The antiviral function of BET protein against SARS-CoV-2 infection

Considering the past shreds of evidence on BRD2 and BRD4 associated with viral infections, researchers have recently evaluated the function of all relevant BET proteins during COVID-19 infection.

17 Nov 2021

Scientists use advanced microscopes to delve deeper into protein degradation process

Proteins are the building blocks of all living things. A vast amount research takes place on how these proteins are made and what they do, from enzymes that carry out chemical reactions to messengers that transmit signals between cells.

17 Nov 2021

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

In the current study, researchers compare the IFITM sensitivities of major SARS-CoV-2 VOCs.

17 Nov 2021

Study uncovers the herpes virus' strategy for infecting the nervous system

Herpes type 1 is sealed with a kiss for a lifetime. More than half of U.S. adults are carriers of HSV1 (herpes simplex virus type 1) which hibernates in the peripheral nervous system and can never be eradicated.

17 Nov 2021

Scientists predict structures of eukaryotic protein complexes using AI

UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions.

17 Nov 2021

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

Researchers from the Humboldt-Universität zu Berlin have been investigating the presence of these antibodies in hospitalized COVID-19 patients to examine the potential of using them as a biomarker for severe disease.

17 Nov 2021

Interactions between SARS-CoV-2 S protein and ACE2 receptor using fluorescence correlation spectroscopy

Researchers used advanced two-color fluorescence cross-correlation spectroscopy to demonstrate the interaction between human ACE2 and the S1 subunit of SARS-CoV-2 and SARS-CoV.

17 Nov 2021

SARS-CoV-2 protease suppresses host immune response by cleaving NEMO

A recent study conducted by a team of US-based scientists has highlighted a novel function of 3C-like protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The protease has been found to cleave a human immune signaling protein called NF-kB Essential Modulator (NEMO) and disrupt the host immune response.

16 Nov 2021

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

A new study published in the journal Diagnostics was based on the hypothesis that detecting urinary SARS-CoV-2 nucleic acid––which may result in renal and cardiovascular endothelial destruction to facilitate viral access to the kidney parenchyma—may be used as a specific biomarker to indicate the severity of COVID-19.

16 Nov 2021

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

The creation of nanoscale computers for use in precision health care has long been a dream of many scientists and health care providers.

16 Nov 2021

What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Now, researchers from Public Health Services Israel have been investigating a new variant called Lambda to see if it qualifies as a variant of concern. Their research is published in the journal Eurosurveillance.

16 Nov 2021

Protein C News and Research

Structure of SARS-CoV-2 spike protein postfusion

Blood proteomic survey in undiagnosed population with COVID-19

Real-world effectiveness and safety of COVID-19 vaccines

Toll-like receptor 2 - novel target for improved COVID-19 vaccines

Study shows neutralizing capacity of monoclonal antibodies against SARS-CoV-2 variants of concern

Study leverages the DIAAS system to understand protein quality in meat burgers and plant-based burgers

The antiviral function of BET protein against SARS-CoV-2 infection

Scientists use advanced microscopes to delve deeper into protein degradation process

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

Study uncovers the herpes virus' strategy for infecting the nervous system

Scientists predict structures of eukaryotic protein complexes using AI

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

Interactions between SARS-CoV-2 S protein and ACE2 receptor using fluorescence correlation spectroscopy

SARS-CoV-2 protease suppresses host immune response by cleaving NEMO

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

What genes affect the COVID-19 gender imbalance?

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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