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Improvement in application of health information technology needed for better patient care

The break neck pace of genomic discoveries has ushered in a new problem in the delivery of personalized medicine: comprehensive and consistent data reporting that will improve health information technologies for better patient care.

11 Apr 2013

Incidence of late-onset Alzheimer disease higher among African Americans

In a meta-analysis of data from nearly 6,000 African Americans, Alzheimer disease was significantly associated with a gene that have been weakly associated with Alzheimer disease in individuals of European ancestry, although additional studies are needed to determine risk estimates specific for African Americans, according to a study in the April 10 issue of JAMA, a Genomics theme issue.

11 Apr 2013

Research: African-Americans with ABCA7 gene variant have double risk of developing AD

African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimer's disease compared with African-Americans who lack the variant.

10 Apr 2013

Researchers use metagenomics to reconstruct genome sequence of Shiga-toxigenic Escherichia coli

Researchers have been able to reconstruct the genome sequence of an outbreak strain of Shiga-toxigenic Escherichia coli using metagenomics (the direct sequencing of DNA extracted from microbiologically complex samples), according to a study in the April 10 issue of JAMA, a Genomics theme issue.

10 Apr 2013

Researchers discover genetic variants of heart disorder in some cases of stillbirth

In a first-of-its-kind study, researchers from the United States and Europe discovered genetic mutations associated with long QT syndrome, a genetic abnormality in the heart's electrical system, in a small number of intrauterine fetal deaths, according to a study in the April 10 issue of the Journal of the American Medical Association.

10 Apr 2013

MD Anderson scientists demonstrate new way to restore tumor suppression

Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other two genes but also shut down its own cancer-stifling fraternal twin.

10 Apr 2013

Gene variations can predispose people to chemotherapy-induced peripheral neuropathy

Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found.

10 Apr 2013

Newly discovered mouse viruses can pave the way for future progress in hepatitis research

Newly discovered mouse viruses could pave the way for future progress in hepatitis research, enabling scientists to study human disease and vaccines in the ultimate lab animal.

9 Apr 2013

Genes for blood vessel growth in retina are "switched on" by SRF protein

Normal functioning of the eye depends on a proper supply of blood to the retina. Light entering the eye passes through the cornea, the lens, and the vitreous body before reaching the retina, where it stimulates the nerves.

9 Apr 2013

Researchers discover that fruit fly mutation holds clues for treating motor neuron diseases

A team of researchers, led by Marc Freeman, PhD, an early career scientist with the Howard Hughes Medical Institute and associate professor of neurobiology at the University of Massachusetts Medical School have discovered a gene in the fruit fly Drosophila melanogaster that, when mutant, blocks the self-destruction of damaged axons, which could hold clues to treating motor neuron diseases, such as amyotrophic lateral sclerosis.

9 Apr 2013

Transposons increase in abundance and activity in brains as they age

As the body ages, the physical effects are notable; wrinkles in the skin appear, physical exertion becomes harder. But there are also less visible processes going on. Inside aging brains there is another phenomenon at work, which may contribute to age-related brain defects.

9 Apr 2013

Study evaluates efficacy of drug combinations in treating colorectal cancer

Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Once colorectal cancer has spread to other parts of the body, only 11 percent of patients will survive five years from the date of their diagnosis.

8 Apr 2013

Researchers identify seven new gene loci linked to obesity

An international research team has identified seven new gene loci linked to obesity. Researchers were also able to show that the genetic mechanisms that cause extreme obesity are similar to those that cause milder forms of overweight and obesity.

8 Apr 2013

Researchers use single-cell genome sequencing approach to analyze microbe from biofilm in hospital

A team of researchers led by scientists from the J. Craig Venter Institute (JCVI) has published a study outlining the recovery and genomic analysis, using single-cell genomic techniques, of a periodontal pathogen, Porphyromonas gingivalis, from a hospital sink.

6 Apr 2013

Studies, search for genetic risk factors needed to predict individual's risk for traumatic brain injury

One of the most controversial topics in neurology today is the prevalence of serious permanent brain damage after traumatic brain injury. Long-term studies and a search for genetic risk factors are required in order to predict an individual's risk for serious permanent brain damage, according to a review article published by Sam Gandy, MD, PhD, from the Icahn School of Medicine at Mount Sinai in a special issue of Nature Reviews Neurology dedicated to TBI.

6 Apr 2013

Longer looks: Embarrassing accolades; Mapping the brain; Physician pay

Medicine honors its heroes in many ways. But sometimes high accolades can turn out to be highly embarrassing. Consider the annual award for lifetime achievement in preventing and controlling sexual infections, given since 1972 by the American Sexually Transmitted Diseases Association.

5 Apr 2013

Researchers identify new set of genetic markers for Alzheimer's

Researchers at Washington University School of Medicine in St. Louis have identified a new set of genetic markers for Alzheimer's that point to a second pathway through which the disease develops.

5 Apr 2013

New genetic variants may increase susceptibility to breast, prostate and ovarian cancers

The European Collaborative Oncological Gen-‐Environmental Study (COGS) project, whose main goal is to decipher the complex genetic bases of breast, prostate and ovarian cancers, publishes a total of 12 research articles in several prestigious journals, including Nature Genetics, Nature Communications, The American Journal of Human Genetics and PLOS Genetics.

4 Apr 2013

Illumina releases TruSight Tumor for NGS-based somatic variant detection in solid tumors

Illumina, Inc. today announced the next product in its TruSight line of content sets, TruSight Tumor, for NGS-based somatic variant detection in solid tumors.

From Illumina, Inc. 4 Apr 2013

TGen to present scientific benefits of whole genome sequencing at myeloma workshop

The scientific benefits of whole genome sequencing at the Translational Genomics Research Institute will be presented at the 14th International Myeloma Workshop, April 3-7 at the Kyoto International Conference Center.

4 Apr 2013

Genome News and Research

Improvement in application of health information technology needed for better patient care

Incidence of late-onset Alzheimer disease higher among African Americans

Research: African-Americans with ABCA7 gene variant have double risk of developing AD

Researchers use metagenomics to reconstruct genome sequence of Shiga-toxigenic Escherichia coli

Researchers discover genetic variants of heart disorder in some cases of stillbirth

MD Anderson scientists demonstrate new way to restore tumor suppression

Gene variations can predispose people to chemotherapy-induced peripheral neuropathy

Newly discovered mouse viruses can pave the way for future progress in hepatitis research

Genes for blood vessel growth in retina are "switched on" by SRF protein

Researchers discover that fruit fly mutation holds clues for treating motor neuron diseases

Transposons increase in abundance and activity in brains as they age

Study evaluates efficacy of drug combinations in treating colorectal cancer

Researchers identify seven new gene loci linked to obesity

Researchers use single-cell genome sequencing approach to analyze microbe from biofilm in hospital

Studies, search for genetic risk factors needed to predict individual's risk for traumatic brain injury

Longer looks: Embarrassing accolades; Mapping the brain; Physician pay

Researchers identify new set of genetic markers for Alzheimer's

New genetic variants may increase susceptibility to breast, prostate and ovarian cancers

Illumina releases TruSight Tumor for NGS-based somatic variant detection in solid tumors

TGen to present scientific benefits of whole genome sequencing at myeloma workshop

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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