Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

P681 mutations in SARS-CoV-2 spike protein determine fusogenicity

Researchers evaluated the importance of the P681 residue within the furin cleavage site of SARS-CoV-2 spike protein in determining the fusogenicity and syncytia formation ability of SARS-CoV-2 strains.

2 May 2022

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.

2 May 2022

Longitudinal and proteome-wide analysis of antibodies in COVID-19 patients using a SARS-CoV-2 proteome microarray

The first longitudinal proteome-wide analysis of antibodies in COVID-19 patients has been performed by researchers from the Beijing Institute of Microbiology and Epidemiology and published in the Journal of Advanced Research.

2 May 2022

The generation of SARS-CoV-2 virus-like particles in insect cells

Researchers have reported the development of a promising COVID-19 vaccine candidate which is based on SARS-CoV-2 VLPs, derived from the co-expression of the spike, membrane, and envelope structural proteins in the baculovirus expression system.

2 May 2022

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

An international research group led by Professor Toru Takumi (Senior Visiting Scientist, RIKEN Center for Biosystems Dynamics Research) and Researcher Chia-wen Lin at Kobe University Graduate School of Medicine has shown that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells during fetal development, which results in immune dysregulation in the brain and gut.

2 May 2022

SARS-CoV-2-specific T cells are broader after vaccination than after infection

In a recent study published in the Nature Microbiology journal, researchers investigated the characteristics of coronavirus disease 2019 (COVID-19) infection in convalescent and vaccinated individuals.

1 May 2022

How diet and nutrition impacts lifespan

In a recent study published in the journal Cell, researchers analyzed the association between human longevity to growth and metabolic pathways.

1 May 2022

$Can fractional doses of COVID-19 vaccines protect against SARS-CoV-2?$

Can fractional doses of COVID-19 vaccines protect against SARS-CoV-2?

A recent research paper posted to the Research Square* preprint server assessed the dose fractionation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

1 May 2022

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

A recent research paper posted to the bioRxiv* preprint server demonstrated that a cocktail of two synergetic antibodies extensively neutralized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including Omicron BA.1 and BA.2.

1 May 2022

Researchers test a method for delivering genetic material into the body to repair damaged heart muscle

A method for delivering genetic material to the body is being tested as a way to repair damaged heart muscle after a heart attack.

30 Apr 2022

Uncovering a new molecule that shows potential as antidote for carbon monoxide poisoning

Carbon monoxide is an odorless and colorless gas made when fossil fuels burn incompletely. It's also a silent killer.

29 Apr 2022

Novel therapy using nitric oxide may be an efficient and safe way to treat multiple metabolic diseases

A novel therapy developed at the University of Alabama at Birmingham ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet.

29 Apr 2022

Scientists gain important insights into novel mutation behind synucleinopathies

Parkinson's disease and Lewy body dementia belong to a family of neurodegenerative disorders called synucleinopathies because they are caused by the pathological accumulation of protein alpha-synuclein into structures called Lewy bodies and Lewy neurites in the brain.

29 Apr 2022

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Probenecid shows activity against respiratory syncytial virus

A new study describes the antiviral activity of the approved drug probenecid against respiratory syncytial virus.

29 Apr 2022

Study reveals new approach for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds.

29 Apr 2022

Safety and immunogenicity of three-dose vaccination with the Pfizer/BioNtech SARS-CoV-2 mRNA vaccine

A recent article published in the Med journal reported that the SARS-CoV-2 booster vaccinations enhance the SARS-CoV-2 Omicron sublineage neutralizations.

29 Apr 2022

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

In a recent randomized clinical trial of hospitalized patients with COVID-19 and cardio-metabolic risk factors, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin did not significantly reduce patients' risk of organ failure, kidney problems, or death compared with placebo, although numerically fewer participants treated with dapagliflozin experienced these outcomes. The findings are published in CJASN.

29 Apr 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Clinical characteristics of immunocompromised patients infected with the SARS-CoV-2 Omicron variant

Researchers examined the characteristics and outcomes of COVID-19 in immunocompromised patients.

29 Apr 2022

Protein News and Research

Further Reading

P681 mutations in SARS-CoV-2 spike protein determine fusogenicity

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

Longitudinal and proteome-wide analysis of antibodies in COVID-19 patients using a SARS-CoV-2 proteome microarray

The generation of SARS-CoV-2 virus-like particles in insect cells

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

SARS-CoV-2-specific T cells are broader after vaccination than after infection

How diet and nutrition impacts lifespan

Can fractional doses of COVID-19 vaccines protect against SARS-CoV-2?

Antibody cocktail shows synergetic effects against SARS-CoV-2 Omicron in vitro and in vivo

Researchers test a method for delivering genetic material into the body to repair damaged heart muscle

Uncovering a new molecule that shows potential as antidote for carbon monoxide poisoning

Novel therapy using nitric oxide may be an efficient and safe way to treat multiple metabolic diseases

Scientists gain important insights into novel mutation behind synucleinopathies

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

Probenecid shows activity against respiratory syncytial virus

Study reveals new approach for engineering stable articular cartilage

Safety and immunogenicity of three-dose vaccination with the Pfizer/BioNtech SARS-CoV-2 mRNA vaccine

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Clinical characteristics of immunocompromised patients infected with the SARS-CoV-2 Omicron variant

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