Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Little known enzyme ACAT2 appears to be a factor in cardiovascular disease

New research suggests that a little-studied enzyme ACAT2, may play a major role in cardiovascular disease because it alters the molecular structure of cholesterol.

2 May 2005

Age-related macular degeneration is triggered, possibly by an infection

Age-related macular degeneration, the leading cause of blindness in the elderly, occurs when a common inherited gene variation is triggered, possibly by an infection, according to a new study led by researchers at Columbia University Medical Center and the University of Iowa, with an international research team.

1 May 2005

Symptoms of concussion may increase when the outcome of a lawsuit is at stake

The condition known as “postconcussional syndrome” is difficult to define medically but is generally defined as a string of cognitive, physical or behavioral losses that occur after a head injury.

1 May 2005

Risk scores identify young people with hardened arteries

Armed with more knowledge about what cardiovascular disease looks like in people ages 15 to 34, co-authors from the University of Texas Health Science Center, the Southwest Foundation for Biomedical Research and institutions in Delaware, New York, Pennsylvania and Louisiana will report...

27 Apr 2005

Physical activity appears to inhibit Alzheimer's

Physical activity appears to inhibit Alzheimer's-like brain changes in mice, slowing the development of a key feature of the disease, according to a new study.

26 Apr 2005

Study sheds light on why normal prion proteins may experience age-related mutations in inherited diseases

A new study sheds light on why normal prion proteins may experience age-related mutations in inherited diseases. Researchers at the Case Western Reserve University School of Medicine studied a previously discovered mutation in the prion protein in members of an extended family in Indiana who inherited the prion disease Gerstmann-Straussler-Sheinker (GSS).

25 Apr 2005

Canadian Diabetes Association, UBC partner on funding for childhood diabetes research

A new partnership announced by the Canadian Diabetes Association and the University of British Columbia (UBC) will help fund research in childhood diabetes. Not only will this research further investigate type 1 diabetes, it will also explore the areas of type 2 diabetes and obesity in children, a problem of growing concern and proportions.

23 Apr 2005

Scientists have, for the first time, induced a state of reversible metabolic hibernation in mice

Scientists at Fred Hutchinson Cancer Research Center have, for the first time, induced a state of reversible metabolic hibernation in mice. This achievement, the first demonstration of "hibernation on demand" in a mammal, ultimately could lead to new ways to treat cancer and prevent injury and death from insufficient blood supply to organs and tissues.

23 Apr 2005

Propensity for obesity, diabetes may occur in utero

The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

22 Apr 2005

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary.

22 Apr 2005

RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive.

20 Apr 2005

Breast cancer gene may play a major role in the recurrence of prostate cancer

A gene associated with breast cancer also may play a major role in the recurrence of prostate cancer, according to new research from the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center.

20 Apr 2005

Protein studies may lead to new Alzheimer's test

A study appearing in an upcoming issue of the Journal of Alzheimer's Disease, published by IOS Press, entitled "Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease," may lead to a new test for diagnosing the devastating illness. About 4 million Americans suffer from Alzheimer's disease, the most common form of dementia, characterized by memory loss and an inability to use language.

19 Apr 2005

Dermatologists use patterns to recognize melanoma

Dermatologists depend on overall pattern recognition and comparison rather than specific analytic criteria to distinguish melanoma lesions (malignant skin cancer) from harmless skin moles, according to an article in the April issue of Archives of Dermatology.

19 Apr 2005

Alternate view for pathology of Alzheimer's disease

A new paper from researchers at the Case Western Reserve University School of Medicine challenges the classic theory that the nerve tangles seen in the brains of Alzheimer's disease (AD) victims are the cause of the disease, but rather proposes that they are a protective response to the disease. Their paper appears in the April issue of the journal Trends in Molecular Medicine.

19 Apr 2005

New findings about insulin-signaling in the liver could prove useful in understanding type 2 diabetes

A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.

12 Apr 2005

Novel findings in Balo's concentric sclerosis may shed light on pathology of MS

Researchers partly funded through the National MS Society’s “MS Lesion Project” report that a novel mechanism known as “tissue preconditioning” may explain the pattern of tissue damage that occurs in Baló’s concentric sclerosis, a rare, severe disease similar to MS, and may offer clues to a similar phenomenon in MS. Hans Lassmann, MD (Medical University of Vienna, Wien) and colleagues, including Society grantee Claudia Lucchinetti, MD (Mayo Clinic and Foundation, Rochester, MN), report their findings in Brain.

12 Apr 2005

Researchers discover mechanism by which tumours support their own growth

In a recent issue of the American Journal of Pathology, the Bremen researchers report their findings on a signalling molecule called "High Mobility Group Protein B1" (HMGB1). As a signal sent by tumour cells HMGB1 proteins induce sprouting of blood vessels that supply tumours with oxygen, thus promoting tumour growth.

11 Apr 2005

The liver may produce most of the body's good cholesterol

Research in mice suggests that the liver may produce most of the body's "good" cholesterol, an unexpected finding that might one day help scientists develop new treatments to raise levels of this heart-protecting molecule in humans.

10 Apr 2005

Use of smokeless tobacco helped hard-to-quit smokers give up their habit

The study, published in the January-March issue of the Journal of Psychoactive Drugs, reports on subjects who were contacted seven years after completion of a smoking cessation program that replaced cigarettes with smokeless tobacco products as a harm-reduction strategy.

7 Apr 2005