Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Galapagos initiates phase II clinical study of GLPG0259 drug in RA patients

Galapagos NV announced today that it has started a Phase II clinical study for the Company's flagship program GLPG0259, a novel drug being developed for rheumatoid arthritis. In this clinical trial, the safety and efficacy of this novel candidate drug will be tested in RA patients. Galapagos plans to announce interim results by the middle of next year and complete the trial by the end of 2011.

28 Sep 2010

Researchers publish evidence behind evolution of jaws in vertebrates

A half-billion years ago, vertebrates lacked the ability to chew their food. They did not have jaws. Instead, their heads consisted of a flexible, fused basket of cartilage.This week, an international team of researchers led by a faculty member from the University of Colorado at Boulder published evidence that three genes in jawless vertebrates might have been key to the development of jaws in higher vertebrates.

27 Sep 2010

Calcitonin combination therapy may help treat osteoarthritis: Study

Tarsa Therapeutics, Inc. and Unigene Laboratories, Inc. today reported preclinical data showing that calcitonin may have synergistic effects in combination with other drugs in reducing the collagen degradation associated with osteoarthritis.

27 Sep 2010

Interleukin Genetics announces clinical study data on osteoarthritis progression

Interleukin Genetics, Inc. and the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill announced today findings from a large clinical study to evaluate the role of genetic factors in osteoarthritis progression which showed patients with radiographic evidence of knee osteoarthritis who inherited a specific pattern of genetic variations in the interleukin-1 receptor antagonist (IL-1Ra) gene were almost twice as likely to progress to severe disease as other patients.

23 Sep 2010

Study links progressive osteoarthritis to IL-1Ra gene variations

Scientists from University of North Carolina at Chapel Hill School of Medicine and Interleukin Genetics, Inc. announced today findings from a large clinical study to evaluate the role played by genetic factors in the worsening of osteoarthritis.

22 Sep 2010

New genes associated with osteoarthritis progression

21 Sep 2010

Nine new projects to uncover link between diet and health

9 new projects aimed at uncovering links between diet and health and worth a total of £4M are announced today by a public-private partnership of three research councils (BBSRC, EPSRC and MRC) and 13 food and drink companies. The new projects tackle issues such as reducing fat content or proportion of saturated fat in food, fortification with bioactive compounds including Omega-3 polyunsaturated fatty acids and antioxidants and increasing the dietary fibre in white bread.

15 Sep 2010

Broccoli blocks joint destruction in osteoarthritis: Research

Scientists at the University of East Anglia (UEA) are launching a groundbreaking new project to investigate the benefits of broccoli in the fight against osteoarthritis.Initial laboratory research at UEA has found that a compound in broccoli called sulforaphane blocks the enzymes that cause joint destruction in osteoarthritis the most common form of arthritis.

15 Sep 2010

World Congress on Arthrosis to take place in Belgium from September 23 to 26, 2010

Over a 1000 experts from the world will participate in the Osteoarthritis Research Society International (OARSI) congress, under the Presidency of the Belgian Professor Yves Henrotin (University of Liège).

14 Sep 2010

Geron, UCS collaborate to develop hESC-derived chondrocytes for cartilage damage, joint disease treatment

Geron Corporation today announced that the company has entered into a collaboration with University Campus Suffolk (UCS) in the U.K. to develop human embryonic stem cell-derived chondrocytes for the treatment of cartilage damage and joint disease.

13 Sep 2010

Geron signs worldwide, exclusive license agreement with University of Edinburgh

Geron Corporation today announced that it has entered into a worldwide, exclusive license agreement with the University of Edinburgh covering technology that allows the efficient production of chondrocytes (cartilage forming cells) from human pluripotent stem cells.

13 Sep 2010

Tornier pyrocarbon shoulder prostheses reduce patient pain, offered shorter recovery time

Tornier, Inc., a global leader in extremity and sports medicine orthopaedics, announced today the successful early clinical results of the first seven pyrocarbon shoulder prostheses that were implanted between April 2009 and December 2009.

10 Sep 2010

BioMimetic completes 100 day PMA meeting with FDA for Augment Bone Graft

BioMimetic Therapeutics, Inc. today announced it completed its 100 day Premarket Approval Application (PMA) meeting with the Food and Drug Administration (FDA) regarding the review of Augment™ Bone Graft for the treatment of foot and ankle fusions in the U.S. The FDA generally meets with the PMA sponsor approximately 100 days after the filing of the PMA with the purpose of discussing the status of the application.

9 Sep 2010

KRN cell transfer model provides novel opportunity for rheumatoid arthritis research

Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis, a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology.

8 Sep 2010

First UK PyroTITAN Humeral Resurfacing Implant performed at BMI - The Alexandra Hospital

Ascension Orthopedics, Inc., the world leader in PyroCarbon orthopedic devices, announces the implantation of the first PyroTITAN™ Humeral Resurfacing Implant in the United Kingdom. The PyroTITAN was implanted at BMI - The Alexandra Hospital in Cheadle, Cheshire.

31 Aug 2010

New non-invasive method to diagnose osteoarthritis

Researchers at New York University have developed an innovative way to look at the development of osteoarthritis in the knee joint-one that relies on the examination of sodium ions in cartilage. Their work, which appears in the Journal of Magnetic Resonance, may provide a non-invasive method to diagnose osteoarthritis in its very early stages.

30 Aug 2010

Holy Cross Hospital performs first advanced sensor assisted knee surgery

The first advanced sensor assisted knee surgery in the world has been performed at Holy Cross Hospital in Fort Lauderdale, Fla. Through collaboration with OrthoSensor, Inc. in Fort Lauderdale, the new sensor technology is designed to improve patient recovery and overall implant function.

25 Aug 2010

Fluid dynamics and mechanics to simulate stent design and coating

Suncica "Sunny" Canic was good at math in school, so that's what she pursued as a career. But she always liked medicine, too. When she moved to Houston, Texas, and met some cardiologists at a party, she started talking with them about what they do-and knew she could help them.

23 Aug 2010

'Rotten eggs' gas inside knee joint protects against inflammation

Hydrogen sulfide (H2S) is a gas more commonly associated with the smell of 'rotten eggs' and blocked drains. However, it has now been shown to be present naturally in our bodies and reside in knee joint synovial fluid, the protective fluid found in the cavities of joints that reduces friction between the cartilage of joints during movement. Synovial fluid H2S may play a role in reducing inflammation in joints.

21 Aug 2010

Podiatrist reduces leg amputation risk in diabetics: Study

People with diabetic foot problems can lower their risk of leg amputation by relying on coordinated care that includes a podiatrist, according to a recent study. For instance, those with diabetes-related foot ulcers can reduce their risk of amputation by 31 percent.

19 Aug 2010