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Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Genentech, a member of the Roche Group, announced today interim clinical data from the dose-finding parts of the pivotal FIREFISH and SUNFISH studies investigating risdiplam in spinal muscular atrophy.

3 Oct 2018

Researchers for the first time differentiate human inner ear cells in laboratory

Researchers from the University of Bern and Bern University Hospital have managed for the first time to differentiate human inner ear cells in a laboratory from somatic progenitors and to investigate their origin.

3 Oct 2018

Excessive use of erectile-dysfunction medication could lead to long-term vision problems

In a first-of-its-kind study, Mount Sinai researchers have shown that color vision problems caused by retinal damage on a cellular level can result from a high dose of sildenafil citrate, the popular erectile-dysfunction medication sold under the brand name Viagra.

1 Oct 2018

TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 1 in the journal Nature Communications.

1 Oct 2018

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

Decibel Therapeutics and Oricula Therapeutics today announced that Decibel has obtained an exclusive, worldwide license to the development and commercialization of ORC-13661, an oral medication developed by Oricula Therapeutics for the prevention of hearing loss and balance disorders that can occur following treatment of severe infections with aminoglycoside antibiotics.

27 Sep 2018

Understanding mosquitoes’ mating behavior is key for developing vector control strategies

The ears of male mosquitoes amplify the sound of an approaching female using a self-generated phantom tone that mimics the female's wingbeats, which increases the ear's acoustic input by a factor of up to 45,000, finds a new UCL-led study.

26 Sep 2018

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Researchers from Karolinska Institutet and Kancera AB have developed a molecule that makes cancer cells sensitive to radiotherapy. In a study published in Nature Communications, the researchers describe a new way to block cancer cells' ability to repair their DNA and thus stop the survival of cancer cells.

25 Sep 2018

Lung cancer patients treated with invasive surgery more likely to become chronic opioid users

Patients treated with more-invasive surgical techniques for a type of early-stage lung cancer are more likely to become chronic opioid users than patients treated with minimally invasive surgery, highlighting the need for additional research into how pain management after surgery might be a contributing factor to the opioid addiction crisis, according to a study published in JAMA Oncology in September.

24 Sep 2018

Study offers solid link between visceral organs and brain’s reward, motivation system

A novel gut-to-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published September 20 in the journal Cell.

21 Sep 2018

Muscle relaxants used during general anesthesia can increase risk of pulmonary complications

Muscle relaxants that are used during general anesthesia increase the risk of pulmonary complications after surgery, according to the European milicenter study POPULAR, in which Karolinska Institutet researchers are involved. The study is published in the journal Lancet Respiratory Medicine.

18 Sep 2018

Study: Women exposed to trauma in their lives gave birth to underweight male infants

In the first study of its kind, researchers from the Icahn School of Medicine at Mount Sinai have found significantly lower birth weights in male infants--an average decrease of 38 grams, or approximately 1.3 ounces--born to women who had been exposed to trauma at some point in their lives and who secreted higher levels of cortisol, a hormone related to stress, in late pregnancy.

18 Sep 2018

New fiber laser-based ultrasound sensor may have potential applications in medical diagnostics

By creating a new twist on fiber optic sensors, researchers in China have developed a smart, flexible photoacoustic imaging technique that may have potential applications in wearable devices, instrumentation and medical diagnostics.

18 Sep 2018

Probiotic supplementation may reduce use of antibiotics, scientific analysis shows

Global demand exists for new ways to reduce antibiotic use, given the urgent public health threat of antibiotic resistance.

17 Sep 2018

Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection

The bacteria Pseudomonas aeruginosa can cause serious and difficult to treat infections. The infection process involves the activation of toxic substances from the bacteria by a common protein in our cells.

17 Sep 2018

Study: aPKC inhibitors may provide new therapeutic option for blinding eye diseases

Many eye diseases, including diabetic retinopathy and macular degeneration, exhibit increased permeability of blood vessels in the macular (central) portion of the retina leading to abnormal fluid accumulation and vision loss.

14 Sep 2018

Study uncovers four neuron types in the peripheral auditory system

Researchers at Karolinska Institutet have identified four types of neurons in the peripheral auditory system, three of which are new to science.

12 Sep 2018

Researchers develop new testing device to better diagnose dizziness

Half of over-65s suffer from dizziness and problems with balance. But some tests to identify the causes of such problems are painful and can risk hearing damage.

10 Sep 2018

Researchers use virtual reality goggles to study human anatomy

Tucked away in the back room of a Johns Hopkins research building, a computer hums quietly at a seemingly modest setup of a desktop and a pair of goggles.

6 Sep 2018

Doctor with Guillain Barré syndrome recovers back to normal life

Doctors do the darndest things. Take the one who walked right up to Dan Thomas, MD, at a lecture, got into the ready position, and proceeded to perform several squats as Thomas watched, puzzled.

6 Sep 2018

Scientists shed light on how dangerous inflammations are caused in the brain

The so-called CB1 receptor is responsible for the intoxicating effect of cannabis. However, it appears to act also as a kind of “sensor” with which neurons measure and control the activity of certain immune cells in the brain.

31 Aug 2018

Ear News and Research

Genentech announces clinical data from studies investigating risdiplam in spinal muscular atrophy

Researchers for the first time differentiate human inner ear cells in laboratory

Excessive use of erectile-dysfunction medication could lead to long-term vision problems

TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

Decibel obtains exclusive license to commercialize ORC-13661 for preventing hearing, balance disorders

Understanding mosquitoes’ mating behavior is key for developing vector control strategies

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Lung cancer patients treated with invasive surgery more likely to become chronic opioid users

Study offers solid link between visceral organs and brain’s reward, motivation system

Muscle relaxants used during general anesthesia can increase risk of pulmonary complications

Study: Women exposed to trauma in their lives gave birth to underweight male infants

New fiber laser-based ultrasound sensor may have potential applications in medical diagnostics

Probiotic supplementation may reduce use of antibiotics, scientific analysis shows

Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection

Study: aPKC inhibitors may provide new therapeutic option for blinding eye diseases

Study uncovers four neuron types in the peripheral auditory system

Researchers develop new testing device to better diagnose dizziness

Researchers use virtual reality goggles to study human anatomy

Doctor with Guillain Barré syndrome recovers back to normal life

Scientists shed light on how dangerous inflammations are caused in the brain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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