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University of Miami invests $30 million in neuroscience and aging research

Demonstrating its commitment to excellence as a member of the Association of American Universities and number one in the state for National Institutes of Health (NIH) funding, the University of Miami has pledged to invest more than $30 million to bolster basic science research that will target neuroscience and aging, some of the most complex conditions confronting the United States population, including in South Florida.

17 Oct 2024

Study identifies genetic associations with youth psychopathology

When trying to understand how genetic influences factor into youth behavior, researchers at Washington University in St. Louis have taken the "big trawl" approach, casting their net wide to pull in all the measured traits, behaviors and environments that make up who we are and examine associations with the genetic building blocks comprising risk for mental health problems.

17 Oct 2024

New grant aims to develop rapid biosensors for detecting African swine fever

Foreign animal diseases are a global threat to swine production with the potential for detrimental economic implications.

17 Oct 2024

Pediatric brain tumor research takes leap forward with CBTN data

The Gabriella Miller Kids First Data Resource Center (Kids First DRC) announces the addition of the full Children's Brain Tumor Network (CBTN) dataset to the Kids First DRC portal. This significant milestone provides researchers worldwide with unprecedented access to a vast repository of pediatric brain tumor data, paving the way for groundbreaking discoveries and accelerating the development of innovative treatments.

17 Oct 2024

Genetic analysis shows smoking and high BMI increase dementia risk, but education and exercise protect

Mendelian randomization of 400,000 participants reveals smoking, high BMI, and high cholesterol as major genetic risk factors for dementia, while longer education and physical activity reduce risks.

17 Oct 2024

Adenine base editors show potential to correct X-CGD-causing mutations

A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.

16 Oct 2024

Transposons play essential role in early human development

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

16 Oct 2024

Sapio Sciences enhances bioanalysis LIMS and ELN with advanced immunogenicity capabilities

Sapio Sciences, the science-aware™ lab informatics platform, today announced the addition of new immunogenicity bioanalysis features to its industry-leading lab informatics platform.

From Sapio Sciences 16 Oct 2024

Researchers uncover distinct cell vulnerabilities in Alzheimer’s progression with novel multiomics approach

Researchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.

16 Oct 2024

Historical review reveals French contributions to depression research

In an era where mental health awareness is at the forefront of public discourse, a new historical review is shedding light on the often-overlooked French contributions to our understanding of depression.

16 Oct 2024

Genetic insights transform treatment for children with developmental disorders

Thousands of children with severe developmental disorders have benefited from more targeted treatments and support with genetic insights from the large-scale Deciphering Developmental Disorders (DDD) study, finds a new study.

15 Oct 2024

Mayo Clinic scientists develop mini brain models to study Lewy body dementia

Lewy body dementia (LBD) is a progressive neurodegenerative disease that shares traits with both Parkinson's disease and Alzheimer's disease but can be more difficult to diagnose.

15 Oct 2024

Genomic findings shed light on ancient Japanese population origins

A joint research group led by Jonghyun Kim and Jun Ohashi of the University of Tokyo has demonstrated that the majority of immigration to the Japanese Archipelago in the Yayoi and Kofun periods (between 3000 BCE and 538 CE) came from the Korean Peninsula.

14 Oct 2024

Exploring the role of CPB2 gene in C. perfringens infections

C. perfringens is a widespread bacterium found in the intestines of animals and humans, known for causing severe enteric diseases.

14 Oct 2024

University of Michigan receives $30 million grant to enhance genetic data storage

The University of Michigan will dramatically boost the amount and type of genetic information stored in its massive TOPMed data center and used by researchers and healthcare providers around the world looking to genomes to treat disease.

14 Oct 2024

Epigenomic dynamics shape human brain development and neuropsychiatric disorder risks

Researchers investigate chromatin conformational and epigenomic reorganization during the development of the prefrontal cortex and hippocampus.

14 Oct 2024

Discovery of USP50 protein sheds light on DNA replication processes

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study.

14 Oct 2024

Motor delays and hypotonia differentiate neurodevelopmental disease patients with and without genetic diagnoses

Researchers identified key clinical factors like motor delays and hypotonia that predict genetic diagnoses in children with neurodevelopmental disorders, creating a decision tree to guide clinicians.

14 Oct 2024

Computational tools unlock the secrets of the genome

In collaboration with the International Conference on Research in Computational Molecular Biology (RECOMB), Genome Research publishes a collection of 20 computational methods and their applications in genomics including spatial, single-cell, and long-read sequencing.

13 Oct 2024

New computational pipeline revolutionizes personalized cancer vaccine design

Ludwig Cancer Research scientists have developed a full, start-to-finish computational pipeline that integrates multiple molecular and genetic analyses of tumors and the specific molecular targets of T cells and harnesses artificial intelligence algorithms to use its output to design personalized cancer vaccines for patients.

12 Oct 2024