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Seniors enrolled in both Medicare and Medicaid can experience worse outcomes after ICU hospitalization

Seniors who are enrolled in both Medicare and Medicaid are at risk for experiencing greater worsening of functional status following ICU hospitalization, according to research presented at the ATS 2021 International Conference.

20 May 2021

A better understanding of brain fluid movements can help predict and treat Alzheimer's disease

Scientists don't fully understand what causes Alzheimer's disease, but they have a primary suspect.

20 May 2021

Triple-drug therapy can reduce asthma exacerbations, improve control without major adverse events

Researchers have found that the inclusion of a third drug to commonly used dual-drug inhalers can reduce asthma exacerbations and improve control over the disease in children, adolescents, and adults with moderate-to-severe asthma.

20 May 2021

Four months of multi-drug therapy for tuberculosis is as effective as standard regimen

Four months of multi-drug therapy that included rifapentine and moxifloxacin treated active tuberculosis (TB) as effectively as the standard six-month regimen in a multinational study, cutting treatment time by a third.

20 May 2021

Study could serve as guidepost for developing new therapies for Alzheimer's disease

In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta--the neurotoxin believed to be at the root of Alzheimer's disease (AD)--forms in axons and related structures that connect neurons in the brain, where it causes the most damage.

20 May 2021

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Researchers at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center found that monoclonal antibodies, a COVID-19 treatment administered early after infection, reduce the risk of hospitalization and death by 60 percent in people at high risk of suffering complications from the condition.

20 May 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Human monoclonal antibodies neutralize SARS-CoV-2 in an Fc-independent manner

Researchers from Israel recently isolated a set of SARS-CoV-2 neutralizing monoclonal antibodies from blood samples of patients with severe COVID-19. They were the first to show that transgenic K18-hACE2 mice infected with lethal doses of SARS-CoV-2 can be fully protected by administering antibodies even 3 days after infection

19 May 2021

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.

19 May 2021

Cognitive, behavioral therapy may produce more significant outcomes for obese people

Quality of life relating to physical and mental health can be a key element in the treatment of obese adults.

19 May 2021

Researchers use base editing to sustainably lower high LDL cholesterol levels

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence.

19 May 2021

Spike antibodies after vaccination with Pfizer and Oxford vaccines

A preprint discusses the results of a study of antibody responses to the first and second dose of currently available SARS-CoV-2 vaccines, Pfizer and Oxford.

19 May 2021

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

Researchers have reported the first case of COVID-19 triggering a rare occurrence of potentially severe blood clots forming in the arms.

19 May 2021

The spike proteins of SARS-CoV-2 B.1.617 and B.1.618 variants identified in India provide partial resistance to vaccine-elicited and therapeutic monoclonal antibodies

India’s surge in SARS-CoV-2 infections are linked to the new variants B.1.617 and B.1.618, with mutated spike proteins.

19 May 2021

Researchers find new clue to restore congenital hearing loss

Researchers at Oregon State University have found a key new piece of the puzzle in the quest to use gene therapy to enable people born deaf to hear.

19 May 2021

Lengthy treatment with low-dose 6-mercaptopurine inhibits resistant triple-negative breast cancer cells

The cover for issue 7 of Oncotarget features Figure 5, "SUM149-MA cells surviving a 6-MP treatment are sensitive to chemotherapeutic drugs," published in "Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine" by Singh, et al. which reported that the authors have reported that a lengthy treatment with low-dose 6-mercaptopurine, a clinically useful anti-inflammatory drug, inhibits such resistant cells.

19 May 2021

Randomized clinical trials compare effects of coronary revascularization versus medical therapy alone

A rigorous meta-analysis of randomized clinical trials (RCTs) that compared the effects of medical therapies alone with medical therapies plus revascularization in patients with stable ischemic heart disease (SIHD) was presented at EuroPCR on May 18, 2021.

19 May 2021

Therapy News and Research

Seniors enrolled in both Medicare and Medicaid can experience worse outcomes after ICU hospitalization

A better understanding of brain fluid movements can help predict and treat Alzheimer's disease

Triple-drug therapy can reduce asthma exacerbations, improve control without major adverse events

Four months of multi-drug therapy for tuberculosis is as effective as standard regimen

Study could serve as guidepost for developing new therapies for Alzheimer's disease

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Human monoclonal antibodies neutralize SARS-CoV-2 in an Fc-independent manner

Potential immunotherapy may improve cognitive and behavioral functions after stroke

Cognitive, behavioral therapy may produce more significant outcomes for obese people

Researchers use base editing to sustainably lower high LDL cholesterol levels

Spike antibodies after vaccination with Pfizer and Oxford vaccines

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

The spike proteins of SARS-CoV-2 B.1.617 and B.1.618 variants identified in India provide partial resistance to vaccine-elicited and therapeutic monoclonal antibodies

Researchers find new clue to restore congenital hearing loss

Lengthy treatment with low-dose 6-mercaptopurine inhibits resistant triple-negative breast cancer cells

Randomized clinical trials compare effects of coronary revascularization versus medical therapy alone

Researchers propose new way to treat chronic lung condition

Combination approach can improve the success rate of cancer treatment

People with venom allergies are more likely to have bone marrow disorder

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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