Cancer Therapy News and Research

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Obesity linked to increased risk of cardiotoxicity in chemotherapy-treated patients with breast cancer

Anthracyclines remain a cornerstone of breast cancer therapy in combination with new-generation targeted drugs such as trastuzumab. Both types of drugs are major culprits in chemotherapy-induced heart disease.

23 Dec 2019

National veteran dataset will help dissect the relationship between mental illness and prostate cancer

There appears to be an unhealthy synergy between mental illness and prostate cancer, and researchers are working to dissect the relationship by first assembling the largest dataset ever of veterans with either condition or both.

23 Dec 2019

Kobe scientists develop mathematical model to predict cancer drug side effects

A research team at Kobe University Hospital have further illuminated the likelihood of cancer drug side effects that can occur due to genetic mutations in the drug-metabolizing enzyme.

20 Dec 2019

Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

Final results are published from an evaluation of 42 patients treated with the immune checkpoint inhibitor nivolumab in the large multi-arm precision medicine trial, NCI-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131).

20 Dec 2019

Science has not been able to create a substitute for human blood

Science has been able to create and employ a number of medical marvels, such as the artificial heart and synthetic insulin. But not a substitute for human blood.

19 Dec 2019

Catastrophic macropinocytosis may aid in cancer treatment

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis.

18 Dec 2019

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport receptors.

17 Dec 2019

Conversion of light into heat to fight disease

An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine.

17 Dec 2019

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

A clinical trial investigating the repurposed cancer drug nilotinib in people with Parkinson's disease finds that it is reasonably safe and well tolerated.

17 Dec 2019

Biocompatible hydrogels could help heal wounds, deliver drugs and treat cancer

Hydrogels for healing, synthesized from the molecules up by Rice University bioengineers, are a few steps closer to the clinic.

16 Dec 2019

Salk researchers uncover new function of mitochondria

Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy.

15 Dec 2019

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes.

13 Dec 2019

New strategy could prevent side effects of targeted cancer treatment

Targeted, highly effective cancer treatments often produce debilitating side effects. This is the case with one commonly used therapy which works by blocking the epidermal growth factor receptor, a protein that stimulates cell proliferation.

13 Dec 2019

Oncology social workers offer advice on managing holidays with a life-threatening illness

Stringing the lights, storming the malls and all those parties! Imagine facing these holiday demands while you're tired, sick, sad and worried: for people with cancer or other life-threatening illnesses, this time of year can often be far from merry.

12 Dec 2019

Scientists solve 3D structure of vaccinia virus RNA polymerase

For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host's nucleus can they find the machines, enzymes and building blocks with which they can multiply their genetic material before infecting other cells.

12 Dec 2019

Artificial Intelligence (AI) in Cancer Care

Artificial intelligence (AI) is being tested in clinics around the world, but is it a realistic ambition to apply sophisticated algorithms to cancer care?

From IBM Watson 12 Dec 2019

Yale scientists flip the script on novel cancer therapy to find new insights into lupus

In the last decade, scientists discovered that blocking a key regulator of the immune system helped unleash the body's natural defenses against several forms of cancer, opening up a new era of cancer immunotherapy.

11 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Cancer Therapy News and Research

Obesity linked to increased risk of cardiotoxicity in chemotherapy-treated patients with breast cancer

National veteran dataset will help dissect the relationship between mental illness and prostate cancer

Kobe scientists develop mathematical model to predict cancer drug side effects

Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

Science has not been able to create a substitute for human blood

Catastrophic macropinocytosis may aid in cancer treatment

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Conversion of light into heat to fight disease

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

Biocompatible hydrogels could help heal wounds, deliver drugs and treat cancer

Salk researchers uncover new function of mitochondria

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

New strategy could prevent side effects of targeted cancer treatment

Oncology social workers offer advice on managing holidays with a life-threatening illness

Scientists solve 3D structure of vaccinia virus RNA polymerase

Artificial Intelligence (AI) in Cancer Care

Yale scientists flip the script on novel cancer therapy to find new insights into lupus

New drug combo promises help for triple negative breast cancer patients

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

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