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Scientists find links between bipolar disorder and rare loss-of-function variants in two genes

Scientists at deCODE genetics, a subsidiary of Amgen, reveal today in Nature Genetics associations between bipolar disorder and rare loss-of-function variants in two genes.

25 Mar 2025

ELRIG announces Prof Rory Johnson and Dr Shalini Andersson as keynote speakers at Therapeutic Oligonucleotides 2025

ELRIG, a not-for-profit, volunteer-led organization for the drug discovery community, today announced the keynote speakers for Therapeutic Oligonucleotides 2025 taking place at the AstraZeneca R&D site in Gothenburg, Sweden from 14-15 May. Prof Rory Johnson, Associate Professor, University College Dublin, and Dr Shalini Andersson, Vice President Nucleic Acid Therapeutics, AstraZeneca will lead this year's event focused on 'drugging the undruggable'.

25 Mar 2025

New chromatin tracing method unlocks DNA looping process in high resolution

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves.

24 Mar 2025

Researchers trace 73% of US Salmonella cases to chicken and vegetables

Researchers used genome sequencing and machine learning to trace the top food sources behind Salmonella infections in the US. Chicken and vegetables emerged as the primary culprits, together accounting for up to 73% of human cases with known sources.

23 Mar 2025

Asgard archaea provide clues to the origin of complex life forms

Ten years ago, nobody knew that Asgard archaea even existed. In 2015, however, researchers examining deep-sea sediments discovered gene fragments that indicated a new and previously undiscovered form of microbes.

22 Mar 2025

Bacteria use dormant phages to create immunity against viral invaders

Like people, bacteria get invaded by viruses. In bacteria, the viral invaders are called bacteriophages, derived from the Greek word for bacteria-eaters, or in shortened form, "phages."

22 Mar 2025

250,000 whole genomes sequenced for AGD initiative to advance drug discovery

Nashville Biosciences LLC (NashBio), a leading clinical and genomic data company and wholly owned subsidiary of Vanderbilt University Medical Center, and global DNA sequencing giant Illumina Inc. today announced that 250,000 whole genomes have been sequenced for the Alliance for Genomic Discovery (AGD) initiative.

21 Mar 2025

Cellular models of embryos offer insights into early developmental processes

The earliest days after fertilization, once a sperm cell meets an egg, are shrouded in scientific mystery.

20 Mar 2025

New discovery shows piRNA's adaptive role in silencing jumping genes

Adverse genetic mutations can cause harm and are due to various circumstances. "Jumping genes" are one cause of mutations, but cells try and combat them with a specialized RNA called piRNA.

20 Mar 2025

A versatile toolbox sets gold standard for characterizing IRES activity in cells

Only recently has the ribosome - one of the oldest molecular machines in evolutionary terms - been recognized as an active regulator of gene expression at the level of protein biosynthesis.

20 Mar 2025

New function of Exportin-1 discovered in gene transcription

Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell nuclei of all flora and fauna.

20 Mar 2025

Scientists uncover hints of a potential new cause of stomach cancer

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

19 Mar 2025

Earliest stages and possible new cause of stomach cancer revealed

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

19 Mar 2025

Understanding the role of CD2AP in Alzheimer's disease

A groundbreaking peer-reviewed Thought Leaders Invited Review article in Brain Medicine (Genomic Press, New York) explores how CD2-associated protein (CD2AP) contributes to Alzheimer's disease (AD), one of the most devastating neurodegenerative disorders affecting millions worldwide.

19 Mar 2025