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BioLineRx BL-7010 may reduce gluten toxicity in patients with celiac disease

BioLineRx, a biopharmaceutical development company, announced the publication of pre-clinical results demonstrating that BL-7010, an orally available treatment for celiac disease, reduces gluten toxicity (the negative effect of gluten on the patient's body).

22 Feb 2012

New chemical compound to treat brain damage from stroke

Researchers at the University of Copenhagen have designed, produced and patented a new chemical compound for the possible treatment of brain damage caused by stroke. The compound binds 1,000 times more effectively to the target protein in the brain than the potential drug currently being tested on stroke victims.

22 Feb 2012

Mitochondria may be promising new target for cancer treatment

Mitochondria, tiny structures within each cell that regulate metabolism and energy use, may be a promising new target for cancer therapy, according to a new study. Manipulation of two biochemical signals that regulate the numbers of mitochondria in cells could shrink human lung cancers transplanted into mice, a team of Chicago researchers report in the journal FASEB.

22 Feb 2012

IDOM researchers overturn textbook view of liver metabolism

A team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine, University of Pennsylvania, has overturned a "textbook" view of what the body does after a meal.

22 Feb 2012

Cedars-Sinai scientist to study potential treatments for AD

A Cedars-Sinai research scientist has been awarded two national grants totaling more than $2.5 million, including a prestigious Research Project Grant from the National Institutes of Health to study potential treatments for Alzheimer's disease.

21 Feb 2012

Researchers discover new evidence on how cholesterol transfers from HDLs to LDLs

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from "good" high density lipoproteins (HDLs) to "bad" low density lipoproteins.

21 Feb 2012

Xencor, Boehringer Ingelheim partner to develop and supply biosuperior monoclonal antibodies

Xencor, Inc., a company using its proprietary Protein Design Automation (PDA) platform technology to engineer next-generation antibodies, and Boehringer Ingelheim announced today a collaboration agreement for certain Xencor biosuperior monoclonal antibodies.

21 Feb 2012

Researchers discover identical antibiotic resistant genes in soil bacteria and in pathogens from clinics

Disease-causing bacteria's efforts to resist antibiotics may get help from their distant bacterial relatives that live in the soil, new research at Washington University School of Medicine suggests.

21 Feb 2012

KI's chemical interaction map shows how inhibitors bind to PARP enzymes

A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs.

20 Feb 2012

Researchers track structural changes during formation of new memories

New connections between brain cells emerge in clusters in the brain as animals learn to perform a new task, according to a study published in Nature on February 19 (advance online publication). Led by researchers at the University of California, Santa Cruz, the study reveals details of how brain circuits are rewired during the formation of new motor memories.

20 Feb 2012

Study identifies USP15 as a critical protein in cancer

After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane , Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has today published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise.

20 Feb 2012

Defects in GPR120 protein may lead to obesity and liver disease

Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

19 Feb 2012

Researchers discover class of proteins that detect 'painful touch'

In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."

19 Feb 2012

Protein fragments from yellow field pea seeds can lower blood pressure

There are lots of new ideas out there for giving you extra protection against chronic diseases through the food you eat. But many good ideas may never make it to market. Researchers at the University of Guelph, led by Brian McBride, have found a way to enrich milk with docosahexaeonic acid (DHA)-an essential nutrient that many people are lacking.

19 Feb 2012

The 'nutritional magic' behind soy's heart health benefits

Nutrition science has regarded soy as a superfood with many health benefits for decades. In fact, "25 grams of soy protein per day, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease," according to the FDA.

18 Feb 2012

Scientists discover the off signal for inflammation

Proteins, the building block for all living organisms, are the ultimate transformers - able to splice and switch roles and functions within the human body. But when these changes go wrong, diseases such as cancers and arthritis may result, says University of British Columbia researcher Chris Overall.

18 Feb 2012

TRANSFUSION publishes positive results from CryoStor collaborative research

BioLife Solutions, Inc., a leading developer, manufacturer and marketer of proprietary clinical grade hypothermic storage and cryopreservation freeze media for cells and tissues, today announced that TRANSFUSION, the foremost publication in the world for new information regarding transfusion medicine, has published a peer-reviewed journal article reporting positive results of collaborative research on CryoStor, BioLife's serum-free, protein-free cryopreservation freeze media.

18 Feb 2012

RAD51 gene behind the cause of congenital mirror movements

Further work carried out on mice suggests that this gene plays a part in motor network cross-over. Cross-over is a key factor in the transmission of brain signals, because it allows the right side of the brain to control the left side of the body and vice versa. This research has been published in The American Journal of Human Genetics.

18 Feb 2012

Study reveals immune mechanism for surveillance over EBV infection

Some 90 percent of people are exposed to the Epstein Barr virus (EBV) at some point in their life. Even though it is quickly cleared from the body, the virus can linger silently for years in small numbers of infected B cells.

18 Feb 2012

Scientists observe maturation of immune cells in live zebrafish embryos

T-cells are the immune system's security force. They seek out pathogens and rogue cells in the body and put them out of action. Their precursors are formed in the bone marrow and migrate from there into the thymus. Here, they mature and differentiate to perform a variety of tasks. Scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded for the first time in observing the maturation of immune cells in live zebrafish embryos.

17 Feb 2012