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Researchers develop multiplexed screening approach to study cancer development in mice

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their cancer-causing roles and determining which combinations of genes cooperate to cause liver cancer.

27 Oct 2015

Unique, tiny protein cage developed to deliver chemotherapy chemicals directly to cancer cells

Washington State University researchers have developed a unique, tiny protein cage to deliver nasty chemotherapy chemicals directly to cancer cells. Direct delivery could improve treatment and lessen what can be horrendous side effects from toxic drugs.

27 Oct 2015

Many young women not receiving adequate counseling on heart disease

Only half of younger heart attack patients believed that they were at risk before the onset of an attack, and even fewer discussed health risks with their doctors, according to Yale School of Public Health researchers. The findings were more pronounced among women than men.

27 Oct 2015

Replacing animal-derived antibodies with modern technologies can improve quality of research, reduce costs

Time, money, and tens of thousands of animals could be saved if researchers replace animal-derived antibodies with modern technologies, according to a review by the PETA International Science Consortium Ltd. published today in Biotechnology Advances, a peer-reviewed journal covering developments and trends in biotechnology principles and applications.

27 Oct 2015

New Rice University study explores connections between fatal bereavement and cardiovascular risk

Medical professionals know that when a spouse dies, the surviving partner is at increased risk of suffering early mortality - but they don't entirely understand why. A new Rice University professor has received a $3.765 million R01 grant from the National Institutes of Health to embark on a five-year study of the connection between psychological and physiological responses to such extraordinary stress.

27 Oct 2015

Researchers pinpoint mechanisms that cause chemoresistance in ovarian cancer patients

Resistance to chemotherapy is a major problem for those suffering from ovarian cancer--a problem that prevents a cure from a disease dubbed the "silent killer." University of Georgia researchers are giving patients new hope with recent findings that help pinpoint the mechanisms causing chemoresistance.

27 Oct 2015

MGH researchers identify mechanism behind the spread of neurofibrillary tangles

Massachusetts General Hospital investigators have discovered a mechanism behind the spread of neurofibrillary tangles - one of the two hallmarks of Alzheimer's disease - through the brains of affected individuals.

27 Oct 2015

Scientists decode central signal switch associated with epileptic seizures

Scientists at the University of Bonn and the Hebrew University of Jerusalem (Israel) have decoded a central signal cascade associated with epileptic seizures. If the researchers blocked a central switch in epileptic mice, the frequency and severity of the seizures decreased. Using a novel technology, it was possible to observe the processes prior to the occurrence of epileptic seizures in living animals.

27 Oct 2015

Genetic discovery sheds light on how prostate cancer develops and spreads

A new and important genetic discovery, which sheds light on how prostate cancers develop and spread, has been made by an international research team led by scientists at The University of Nottingham.

27 Oct 2015

Limited use of general anesthesia does not cause developmental problems for children

An international team of researchers that includes a pediatric anesthesiologist from the University of Colorado School of Medicine and Children's Hospital Colorado is reporting that limited use of general anesthesia with an infant does not cause developmental problems for the child.

27 Oct 2015

New article reviews latest advances in magnetic particle tracking in cell therapy

A new article published in Regenerative Medicine reviews the latest advances in magnetic particle tracking in cell therapy, a potentially groundbreaking strategy in disease treatment and regenerative medicine.

27 Oct 2015

New game-based simulation training for firefighters beats home fires, minimizes heart risk

Firefighting isn't what it used to be. Whether it's a complex blaze raging in an urban high-rise or a seemingly straightforward single-level home fire, modern building construction and furnishings have made fighting fires more difficult: Flames burn hotter, produce more smoke, and spread more quickly.

27 Oct 2015

New drug combination may be effective against malignant melanoma

A team of Massachusetts General Hospital investigators has discovered a new combination of drugs that may be effective against one of the deadliest cancers, malignant melanoma. The combination - pairing a drug targeted against mutations in the BRAF gene with a second drug that targets another important signaling pathway - was discovered through one of the largest screens of cancer drug combinations conducted to date.

27 Oct 2015

Ipsen, EpiVax partner to create next generation botulinum neurotoxin and TSI therapeutics

Ipsen and the US company EpiVax, Inc. today announced that they have completed a collaborative project that provides a novel approach for creating next generation botulinum neurotoxin (BoNT) and Targeted Secretion Inhibitor (TSI) therapeutics.

27 Oct 2015

Patients with treatment-resistant autoimmune blood conditions may benefit from sirolimus

The immunosuppressant sirolimus is an effective and safe steroid-sparing therapy for children and young adults with highly treatment-resistant autoimmune blood conditions, according to a study published online today in Blood, the Journal of the American Society of Hematology.

27 Oct 2015

Lewy Body Composite Risk Score detects LBD and Parkinson's disease dementia in three minutes

Although Lewy Body disease (LBD) is the second-most-common degenerative disease after Alzheimer's disease, it's not exactly a household name. It affects more than 1.3 million Americans, is poorly recognized, and diagnosis is often significantly delayed. Patients with LBD simultaneously experience losses in cognitive function, mobility and behavior.

27 Oct 2015

Low-weight, high-repetition resistance training increases bone density in adults

A new research study published in The Journal of Sports Medicine and Physical Fitness finds that low-weight, high-repetition resistance training increases bone mineral density in adults, challenging assumptions that heavy weight-training is required to build bone mineral density. Participants who completed the study experienced up to 8 percent bone mineral density increases in the legs, pelvis, arms and spine.

27 Oct 2015

New fluorescent dye could serve as powerful tool to visualize biological events in living cells

A new photostable fluorescent dye for super resolution microscopy could serve as a powerful tool to visualize biological events and structural details in living cells at real-time for prolonged recording periods.

27 Oct 2015

DNA testing for Down's syndrome could potentially save lives of unborn babies

Offering pregnant women a DNA test for Down's syndrome on the NHS would reduce the dependency on invasive tests and potentially save the lives of unborn babies, a study shows.

27 Oct 2015

Advanced pancreatic cancer patients now have access to new FDA-approved drug, Onivyde

Patients with advanced pancreatic cancer now have access to the new FDA approved drug, Onivyde, that produced significant overall survival rates in an international clinical study conducted in part by researchers at HonorHealth Research Institute and the Translational Genomics Research Institute.

27 Oct 2015

Research News and Research

Researchers develop multiplexed screening approach to study cancer development in mice

Unique, tiny protein cage developed to deliver chemotherapy chemicals directly to cancer cells

Many young women not receiving adequate counseling on heart disease

Replacing animal-derived antibodies with modern technologies can improve quality of research, reduce costs

New Rice University study explores connections between fatal bereavement and cardiovascular risk

Researchers pinpoint mechanisms that cause chemoresistance in ovarian cancer patients

MGH researchers identify mechanism behind the spread of neurofibrillary tangles

Scientists decode central signal switch associated with epileptic seizures

Genetic discovery sheds light on how prostate cancer develops and spreads

Limited use of general anesthesia does not cause developmental problems for children

New article reviews latest advances in magnetic particle tracking in cell therapy

New game-based simulation training for firefighters beats home fires, minimizes heart risk

New drug combination may be effective against malignant melanoma

Ipsen, EpiVax partner to create next generation botulinum neurotoxin and TSI therapeutics

Patients with treatment-resistant autoimmune blood conditions may benefit from sirolimus

Lewy Body Composite Risk Score detects LBD and Parkinson's disease dementia in three minutes

Low-weight, high-repetition resistance training increases bone density in adults

New fluorescent dye could serve as powerful tool to visualize biological events in living cells

DNA testing for Down's syndrome could potentially save lives of unborn babies

Advanced pancreatic cancer patients now have access to new FDA-approved drug, Onivyde

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