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Neuronal cilia are important for dopamine receptor 1 signaling, study shows

A historically overlooked rod-like projection present on nearly every cell type in the human body may finally be getting its scientific due: A new study has found that these appendages, called cilia, on neurons in the brain have a key role in ensuring a specific dopamine receptor's signals are properly received.

9 Aug 2022

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

9 Aug 2022

MIT researchers develop an easy-to-use test to predict Covid-19 immunity

Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection, or a combination of the two. But, just how much protection does any individual person have?

9 Aug 2022

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

Research led by Drs. Yuhai Zhao and Walter J Lukiw at the LSU Health New Orleans Neuroscience Center and the Departments of Cell Biology and Anatomy, Neurology and Ophthalmology, reports for the first time a pathway that begins in the gut and ends with a potent pro-inflammatory toxin in brain cells contributing to the development of Alzheimer's disease (AD).

9 Aug 2022

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Researchers assess the impact of extending the interval between primary and booster COVID-19 vaccine doses.

9 Aug 2022

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Around 15 years ago, a group of researchers discovered mutant zebrafish. The eyes of these zebrafish did not develop correctly, resulting in them being significantly smaller than the eyes of wild zebrafish.

9 Aug 2022

Researchers create the most bio-realistic and complex computer models of brain cells

Cedars-Sinai investigators have created the most bio-realistic and complex computer models of individual brain cells - in unparalleled quantity.

9 Aug 2022

Aberrant levels of three microRNAs may impair healing in venous ulcers, study shows

The study, which includes the first resource detailing the role of microRNAs in the wound-repair process, shows that aberrant levels of a trio of microRNAs may impair healing in venous ulcers.

9 Aug 2022

Researchers develop a potential way to tackle one of the underlying causes of asthma

A possible way to tackle one of the underlying causes of asthma has been developed by researchers from Aston University and Imperial College London.

9 Aug 2022

Study uncovers how common genetic mutations cause renal cancer

The understanding of the link between common genetic mutations and certain cancers is increasing.

9 Aug 2022

Double mRNA COVID-19 vaccination found to increase SARS-CoV-2 variant recognition

Researchers evaluated the impact of double BNT162b2 messenger ribonucleic acid (mRNA) vaccination in recognition of SARS-CoV-2 variants of concern.

9 Aug 2022

Scientists explore ex utero generation of post-gastrulation synthetic embryos

Researchers showed that post-gastrulation synthetic embryos (sEmbryos) could be synthesized outside the uterus using mouse naive embryonic stem cells (ESCs).

9 Aug 2022

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

A recent study published in Cell illustrated a human genome map with dosage sensitivity across disorders.

9 Aug 2022

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

Researchers demonstrated differential utilization of the B cell germlines and SARS-CoV-2 spike protein epitopes by cross-neutralizing antibodies in infected, vaccinated and individuals with hybrid immunity.

9 Aug 2022

How does the interval between the 1st and 2nd BNT162b2 doses impact the neutralization breadth and potency against variants of concern?

Scientists explored the influence of SARS-CoV-2 extended gap vaccination on the variants of concern neutralization.

9 Aug 2022

Evaluating vaccine effectiveness against Omicron BA.5 and BA.2 in Portugal

Researchers estimated the vaccine effectiveness (VE) of the primary and booster doses of COVID-19 vaccines against reinfection by Omicron BA.5 and BA.2 lineages and severe post-infection outcomes.

9 Aug 2022

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Novel AI tools accurately predict the role of DNA’s regulatory elements

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

9 Aug 2022

Study reveals key similarities between the nervous system of two early-diverging animal lineages

Neurons, the specialized cells of the nervous system, are possibly the most complicated cell type ever to have evolved. In humans, these cells are capable of processing and transmitting vast sums of information. But how such complicated cells first came about remains a long-standing debate.

9 Aug 2022

Powerful injectable gel provides hope for preventing glioblastoma relapse

Like the hardiest weed, glioblastoma almost always springs back - usually within months after a patient's initial brain tumor is surgically removed.

8 Aug 2022

B Cell News and Research

Neuronal cilia are important for dopamine receptor 1 signaling, study shows

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

MIT researchers develop an easy-to-use test to predict Covid-19 immunity

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Researchers create the most bio-realistic and complex computer models of brain cells

Aberrant levels of three microRNAs may impair healing in venous ulcers, study shows

Researchers develop a potential way to tackle one of the underlying causes of asthma

Study uncovers how common genetic mutations cause renal cancer

Double mRNA COVID-19 vaccination found to increase SARS-CoV-2 variant recognition

Scientists explore ex utero generation of post-gastrulation synthetic embryos

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

How does the interval between the 1st and 2nd BNT162b2 doses impact the neutralization breadth and potency against variants of concern?

Evaluating vaccine effectiveness against Omicron BA.5 and BA.2 in Portugal

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Novel AI tools accurately predict the role of DNA’s regulatory elements

Study reveals key similarities between the nervous system of two early-diverging animal lineages

Powerful injectable gel provides hope for preventing glioblastoma relapse

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