Efficacy News and Research

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Mice study explains why antidepressants don't work in some patients

SSRI antidepressants (Selective Serotonin Reuptake Inhibitors, the best known being Prozactm) are amongst the most commonly taken medicines.

20 Sep 2016

Study shows continuous electrical stimulation suppresses seizures in patients with epilepsy

When surgery and medication don't help people with epilepsy, electrical stimulation of the brain has been a treatment of last resort.

20 Sep 2016

Sarepta Therapeutics wins accelerated approval from FDA for Duchenne muscular dystrophy drug

The U.S. Food and Drug Administration today approved Exondys 51 (eteplirsen) injection, the first drug approved to treat patients with Duchenne muscular dystrophy (DMD).

19 Sep 2016

Study compares different strategies to prevent malaria among pregnant women in sub Saharan Africa

A novel strategy to screen pregnant women for malaria with rapid diagnostic tests and treat the test-positive women with effective antimalarials does not lower the risk of adverse pregnancy outcomes compared with treating all pregnant women with the malaria preventive sulfadoxine-pyrimethamine (SP) in sub-Saharan Africa, according to an open label randomized trial published this week in PLOS Medicine by Feiko ter Kuile, of the Liverpool School of Tropical Medicine, and colleagues.

19 Sep 2016

Researchers find switch that helps restore damaged axons

Researchers at the University of Wisconsin-Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons.

16 Sep 2016

Noise levels in nightclubs may induce hearing loss

A new study raises concerns about the noise level in nightclubs. Researchers in Southern California have found that the average continuous level of noise in some nightclubs is at least 91.2 dBA (A-weighted decibels).

16 Sep 2016

Clinical trial assesses efficacy of experimental treatment in individuals with cervical spinal cord injury

Physicians at Rush University Medical Center became the first in Illinois to inject AST-OPC1 (oligodendrocyte progenitor cells), an experimental treatment, into the damaged cervical spine of a recently paralyzed man as part of a multicenter clinical trial.

14 Sep 2016

Research findings may pave way for innovative treatments of multiple sclerosis

Researchers at the Research Center for Immunotherapy and the Focus Program Translational Neurosciences of Johannes Gutenberg University Mainz have identified a new mechanism that is involved in the development of autoimmune diseases.

14 Sep 2016

Researchers develop method to predict disease activity in multiple sclerosis

Cells in the immune system of patients with multiple sclerosis behave differently from those of healthy individuals. Researchers at Linköping University in Sweden have exploited this difference to develop a method that can predict disease activity in multiple sclerosis.

14 Sep 2016

Study provides insight into how weight-loss drug acts in the brain

A weight-loss drug dampened the response to food cues in regions of the brain associated with attention and emotion, leading to decreases in caloric intake, weight and body mass index (BMI), a team led by scientists at Beth Israel Deaconess Medical Center reported.

12 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

UTHealth receives DOD award to investigate stem cell therapy in adults with TBI

A research team led by Charles S. Cox, Jr., M.D., at The University of Texas Health Science Center at Houston has been awarded $6.8 million from the U.S. Department of Defense to assess the safety and efficacy of using autologous stem cell therapy in adults with emergent traumatic brain injury.

9 Sep 2016

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy.

9 Sep 2016

Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Type II diabetes and Parkinson's disease may not appear to have much in common but a look below the surface reveals important molecular similarities that provide a potential target for fighting Parkinson's.

8 Sep 2016

Component of general anesthetic shows improvement in patients with treatment-resistant depression

A new study in Biological Psychiatry reports that esketamine, a component of the general anesthetic ketamine, shows rapid and significant improvement in depressive symptoms in patients who do not respond to currently available therapies.

8 Sep 2016

Changing dosing regimen could improve efficacy of malaria vaccine candidate, study shows

Researchers at the Walter Reed Army Institute of Research and collaborators recently published results of a phase II study which demonstrated that by changing the dosing regimen, the efficacy of malaria vaccine candidate, RTS,S/AS01, was improved to approximately 87%, compared with 63% using the current standard regimen.

7 Sep 2016

Schizophrenia drug slows pancreatic tumor growth in mice

A receptor for the dopamine neurotransmitter promotes growth and spread of pancreatic cancer -- and schizophrenia drugs, which block the function of this receptor, slowed tumor growth and metastatic spread in mice, according to researchers at McGill University and the German Cancer Research Center.

7 Sep 2016

Experts recommend removal of restrictions in accessing new hepatitis C therapies for drug users

Global health experts are today are calling for the removal of restrictions preventing people who use drugs from accessing new hepatitis C cures. So long as these restrictions exist, the goal of disease elimination will remain out of reach, they say.

7 Sep 2016

Researchers find genomic material from Zika virus in tears

Researchers have found that Zika virus can live in eyes and have identified genetic material from the virus in tears, according to a study from Washington University School of Medicine in St. Louis.

7 Sep 2016

Studies examine effectiveness of nasal sprays in reducing frequency, duration of HHT-related epistaxis

Two studies appearing in the September 6 issue of JAMA examine the effectiveness of nasal sprays to reduce the frequency and duration of nosebleeds caused by hereditary hemorrhagic telangiectasia (HHT), an inherited condition characterized by abnormal blood vessels which are delicate and prone to bleeding.

6 Sep 2016

Efficacy News and Research

Mice study explains why antidepressants don't work in some patients

Study shows continuous electrical stimulation suppresses seizures in patients with epilepsy

Sarepta Therapeutics wins accelerated approval from FDA for Duchenne muscular dystrophy drug

Study compares different strategies to prevent malaria among pregnant women in sub Saharan Africa

Researchers find switch that helps restore damaged axons

Noise levels in nightclubs may induce hearing loss

Clinical trial assesses efficacy of experimental treatment in individuals with cervical spinal cord injury

Research findings may pave way for innovative treatments of multiple sclerosis

Researchers develop method to predict disease activity in multiple sclerosis

Study provides insight into how weight-loss drug acts in the brain

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

UTHealth receives DOD award to investigate stem cell therapy in adults with TBI

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Component of general anesthetic shows improvement in patients with treatment-resistant depression

Changing dosing regimen could improve efficacy of malaria vaccine candidate, study shows

Schizophrenia drug slows pancreatic tumor growth in mice

Experts recommend removal of restrictions in accessing new hepatitis C therapies for drug users

Researchers find genomic material from Zika virus in tears

Studies examine effectiveness of nasal sprays in reducing frequency, duration of HHT-related epistaxis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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