Genome News and Research

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BGI Tech achieves whole exome sequencing analysis of total degraded DNA from FFPE samples

BGI Tech Solutions Co., Ltd., a subsidiary company of BGI, announced today that they have achieved whole exome sequencing analysis of total degraded DNA as low as 200 ng from formalin fixed paraffin embedded (FFPE) samples.

19 Sep 2012

Study finds major reason why melanoma is largely resistant to chemotherapy

Researchers with UC Irvine's Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy.

18 Sep 2012

Natural antibiotic to treat tuberculosis

A natural product secreted by a soil bacterium shows promise as a new drug to treat tuberculosis report scientists in a new study published in EMBO Molecular Medicine. A team of scientists working in Switzerland has shown how pyridomycin, a natural antibiotic produced by the bacterium Dactylosporangium fulvum, works.

17 Sep 2012

MVK mutations linked to disseminated superficial actinic porokeratosis

A Chinese research team, led by Anhui Medical University and BGI, has found the strong genetic evidences of mevalonate kinase gene (MVK) mutations link to disseminated superficial actinic porokeratosis (DSAP).

17 Sep 2012

Consumer Genetics Conference to take place from October 3-5

Advancements in sequencing and diagnostics technology are the underlying elements driving the genomic revolution. With the free-falling cost of sequencing, richer reference data and improved interpretation methods, the use of personal genomics is beginning to take greater root in clinical practice.

15 Sep 2012

New NHGRI grants to help develop technologies to dramatically reduce DNA sequencing costs

Grants of almost $19 million will help to develop technologies to dramatically reduce the cost of DNA sequencing, the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, announced today.

15 Sep 2012

New stem cell differentiation study could help scientists better understand genetic basis of CVD

The fate of an embryonic stem cell, which has the potential to become any type of body cell, is determined by a complex interaction of genes, proteins that bind DNA, and molecules that modify those genes and proteins.

15 Sep 2012

Wake Forest Baptist to identify genetic variants associated with premature cardiovascular disease

Researchers at Wake Forest Baptist Medical Center are leading a four-year, $8.9 million national project to identify variations in the human genome and corresponding changes in the arterial proteins associated with premature development of atherosclerosis.

15 Sep 2012

People with genetic mutation for Huntington's disease learn faster: Study

People who bear the genetic mutation for Huntington's disease learn faster than healthy people. The more pronounced the mutation was, the more quickly they learned. This is reported by researchers from the Ruhr-Universität Bochum and from Dortmund in the journal Current Biology.

15 Sep 2012

Whole-genome scan can help doctors choose best treatment option for children with neuroblastoma

A whole-genome scan to identify large-scale chromosomal damage can help doctors choose the best treatment option for children with neuroblastoma, one of the most common types of childhood cancer, finds an international collaboration jointly led by The Institute of Cancer Research, London.

15 Sep 2012

Genomes of lung cancer smokers have more mutations

Lung cancer patients with a history of smoking have 10 times more genetic mutations in their tumors than those with the disease who have never smoked, according to a new study from Washington University School of Medicine in St. Louis.

14 Sep 2012

Researchers identify novel genes that make some children cope with malaria

Researchers from Sainte-Justine University Hospital Center and University of Montreal have identified several novel genes that make some children more efficient than others in the way their immune system responds to malaria infection.

12 Sep 2012

Pregnancy exposures may increase risk of breast cancer in multiple generations of offspring

Chemicals or foods that raise estrogen levels during pregnancy may increase cancer risk in daughters, granddaughters, and even great-granddaughters, according to scientists from Virginia Tech and Georgetown University.

12 Sep 2012

APS conference to explore potential mechanisms behind health benefits of exercise

The effects of physical inactivity are, literally, hazardous to your health. Although the detrimental effects of being inactive are generally thought to be associated with childhood obesity and Type 2 diabetes, they have a significant impact on other illnesses. Physical inactivity contributed at least 25 percent to the prevalence of hip fractures, osteoporosis, coronary heart disease, and colon cancer according to recent data released by the U.S. Department of Health and Human Services.

12 Sep 2012

Study discovers pathways that govern instability of GAA/TTC repeats

A study of more than 6,000 genes in a common species of yeast has identified the pathways that govern the instability of GAA/TTC repeats. In humans, the expansions of these repeats is known to inactivate a gene - FXN - which leads to Friedreich's ataxia, a neurodegenerative disease that is currently incurable. In yeast, long repeats also destabilize the genome, manifested by the breakage of chromosomes.

11 Sep 2012

Sifting through the junk with ENCODE

The first large-scale results from the ENCylopedia Of DNA Elements Consortium have shed light on possible functions of large areas of the genome previously thought of as “junk DNA.”

10 Sep 2012

HIV viruses with two genetic 'footprints' associated with greater vaccine efficacy

Scientists used genetic sequencing to discover new evidence that the first vaccine shown to prevent HIV infection in people also affected the viruses in those who did become infected. Viruses with two genetic "footprints" were associated with greater vaccine efficacy. The results were published today in the online edition of the journal Nature.

10 Sep 2012

Automated system for mapping protein-DNA interactions

Since the sequencing of the human genome in 2001, all our genes - around 20,000 in total - have been identified. But much is still unknown - for instance where and when each is active. Next to each gene sits a short DNA segment, and the activity of this regulatory segment determines whether the gene will be turned on, where and how strongly.

10 Sep 2012

Researchers identify many potential therapeutic targets for squamous cell lung cancers

A new paper published online in Nature holds out hope that people with the second most common type of lung cancer may one day benefit from targeted therapies that have transformed treatments for other lung cancer patients.

10 Sep 2012

Researchers identify genetic variations linked with onset of Barrett's oesophagus

Genetic variations that are linked with the onset of Barrett's oesophagus (BE), a pre-cancerous condition of the lower end of the gullet, have been identified for the first time. The discovery of variations in regions on two chromosomes makes it possible to develop screening tests for people at high risk of developing the disease.

10 Sep 2012

Genome News and Research

BGI Tech achieves whole exome sequencing analysis of total degraded DNA from FFPE samples

Study finds major reason why melanoma is largely resistant to chemotherapy

Natural antibiotic to treat tuberculosis

MVK mutations linked to disseminated superficial actinic porokeratosis

Consumer Genetics Conference to take place from October 3-5

New NHGRI grants to help develop technologies to dramatically reduce DNA sequencing costs

New stem cell differentiation study could help scientists better understand genetic basis of CVD

Wake Forest Baptist to identify genetic variants associated with premature cardiovascular disease

People with genetic mutation for Huntington's disease learn faster: Study

Whole-genome scan can help doctors choose best treatment option for children with neuroblastoma

Genomes of lung cancer smokers have more mutations

Researchers identify novel genes that make some children cope with malaria

Pregnancy exposures may increase risk of breast cancer in multiple generations of offspring

APS conference to explore potential mechanisms behind health benefits of exercise

Study discovers pathways that govern instability of GAA/TTC repeats

Sifting through the junk with ENCODE

HIV viruses with two genetic 'footprints' associated with greater vaccine efficacy

Automated system for mapping protein-DNA interactions

Researchers identify many potential therapeutic targets for squamous cell lung cancers

Researchers identify genetic variations linked with onset of Barrett's oesophagus

Genetics & Genomics - Second Edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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