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Researchers reach new milestone in understanding muscle formation

Researchers from the Randall Centre for Cell & Molecular Biophysics believe they have reached a new milestone in the understanding of muscle formation that could help define new cellular and molecular approaches in pathological conditions affecting muscle wellness.

24 Oct 2018

Study uncovers new mechanism of action in a first-line drug for diabetes

For decades, metformin has been the first-line drug in the treatment of type 2 diabetes, lowering blood glucose levels by inhibiting glucose production in the liver. Metformin also improves glucose uptake and use by muscle tissue.

23 Oct 2018

New topical gel can prevent pesticide-induced toxicity and lethality

Farmers are exposed to toxic pesticides, through skin contact and inhalation, during the spraying of pesticides. This is a severe health hazard. In the last year, from the Vidharbha region in Maharashtra alone, spraying is thought to have led to over 40 deaths, 25 cases of lost vision, and over 1000 hospitalizations.

22 Oct 2018

Genetically modifying zebrafish provides numerous, highly accurate disease models

Research published today describes how zebrafish can be genetically engineered to produce more accurate models of human disease.

18 Oct 2018

Analyzing mouse’s potential as animal model of decision-making

Mice can be used to study the neural circuits underlying complex decision-making, suggests an analysis of more than 500,000 mouse decisions reported in JNeurosci.

From Society for Neuroscience 17 Oct 2018

Kent State professor receives grant to study role of oxytocin in the developing brain

Heather Caldwell, Ph.D., a professor in Kent State University's Department of Biological Sciences, recently received a $450,000 grant to study the role that oxytocin plays in the developing brain.

12 Oct 2018

Scientists discover molecular link between body weight and early-onset puberty

Becoming overweight at a young age can trigger a molecular chain reaction that leads some girls to experience puberty early, according to new research published in Nature Communications.

11 Oct 2018

Researchers develop organoid that functions as real salivary gland

Researchers have successfully used induced pluripotent stem cells to grow a 3D salivary gland tissue that produces saliva when implanted in mice.

11 Oct 2018

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

Researchers have successfully used prenatal gene editing (CRISPR-Cas9) to prevent a fatal metabolic disorder in an animal model.

8 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Gut microbiome appears to play key role in heart transplant outcomes

In a new study, researchers at the University of Maryland School of Medicine have found that the gut microbiome appears to play a key role in how well the body accepts a transplanted heart. The scientists found a causal relationship between the presence of certain microbes and transplant outcome.

4 Oct 2018

Vegetable hormone helps reverse brain alterations caused by high-fat diets, obesity

The Neurobiotechnology research team of the Universitat Jaume I in Castellón, Spain, headed by professor Ana María Sánchez, has proven the positive effects of a vegetable hormone, helping reverse brain alterations caused by high-fat diets, type-2 diabetes, obesity and physical inactivity.

3 Oct 2018

Hopkins gastroenterologists use endoscopic procedure to deliver therapeutic genes to the liver

Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can't find their way into the patient's genomic sequence, they won't help.

3 Oct 2018

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

New research conducted at the Lady Davis Institute at the Jewish General Hospital reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology in an animal model.

25 Sep 2018

Persistent lung inflammation from childhood asthma may increase risk of anxiety later in life

Persistent lung inflammation may be one possible explanation for why having asthma during childhood increases your risk for developing anxiety later in life, according to Penn State researchers.

25 Sep 2018

Toxicological evaluation and dosimetry estimation of potential PET radiotracer

The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesized by our group.

25 Sep 2018

Human-oriented perspective needed to better understand Parkinson's disease

Analysis published in Drug Discovery Today reveals the gap between animal models of Parkinson's disease and our understanding of the neurodegenerative processes underlying the disease, and calls for the implementation of modern, human biology-based technologies to better understand pathological processes and improve treatment outcome.

25 Sep 2018

Study reveals promising new drug candidate to treat acute renal failure

A protein produced by the human body appears to be a promising new drug candidate to treat conditions that lead to acute renal failure. This is shown by a study conducted at São Paulo State University in São José do Rio Preto, Brazil.

20 Sep 2018

Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy

Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain tumors has not been elucidated yet, and it is difficult to treat patients because the tumors do not respond to existing antiepileptic drugs and debilitate children's development.

19 Sep 2018

Potential drugs to treat neurodegenerative diseases garner $3 million grant

A new four-year, $3 million grant will enable Scripps Research scientists to advance compounds that may protect neurons in diseases caused by toxic protein accumulation, including Parkinson's, ALS, Alzheimer's and Creutzfeldt-Jakob disease.

18 Sep 2018

Animal Model News and Research

Researchers reach new milestone in understanding muscle formation

Study uncovers new mechanism of action in a first-line drug for diabetes

New topical gel can prevent pesticide-induced toxicity and lethality

Genetically modifying zebrafish provides numerous, highly accurate disease models

Analyzing mouse’s potential as animal model of decision-making

Kent State professor receives grant to study role of oxytocin in the developing brain

Scientists discover molecular link between body weight and early-onset puberty

Researchers develop organoid that functions as real salivary gland

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Gut microbiome appears to play key role in heart transplant outcomes

Vegetable hormone helps reverse brain alterations caused by high-fat diets, obesity

Hopkins gastroenterologists use endoscopic procedure to deliver therapeutic genes to the liver

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

Persistent lung inflammation from childhood asthma may increase risk of anxiety later in life

Toxicological evaluation and dosimetry estimation of potential PET radiotracer

Human-oriented perspective needed to better understand Parkinson's disease

Study reveals promising new drug candidate to treat acute renal failure

Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy

Potential drugs to treat neurodegenerative diseases garner $3 million grant

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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