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Discovery of 'cellular bike couriers' could shed light on disease spreading mechanisms

A previously unknown component of our cells that delivers proteins like a bike courier in heavy traffic could shed light on the mechanisms that allow cells to spread in diseases such as cancer.

31 Oct 2019

Researchers unveil ultrastructure of focal adhesion scaffold in pluripotent stem cells

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades.

25 Oct 2019

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

The study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signaling complex, the researchers solved the cryo-EM structure of its extracellular region, employing a new approach for data collection.

21 Oct 2019

Brain protein plays a prominent role in the maintenance of chronic pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, according to research conducted at the Icahn School of Medicine at Mount Sinai and published in print October 16, in The Journal of Neuroscience.

11 Oct 2019

Kazan University researchers study the genetics of nephropathia epidemica

This particular inquiry pertains to CCR5 - a gene which has lately been on the focuses of research worldwide. In particular, CCR5 deletion was used in China to perform the first ever genetic editing on human embryos. It's also known that a CCR5-Δ32 mutation can make people immune to HIV.

10 Oct 2019

New link between two important products of nitric oxide discovered

Ever since three US-based researchers working independently unveiled the role of nitric oxide in mediating blood vessel dilation, endothelial cell contraction and smooth muscle relaxation, their discoveries have served as a basis for novel treatments for high blood pressure and erectile dysfunction, among other conditions.

4 Oct 2019

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

A new study has revealed how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that can be transmitted through the generations.

4 Oct 2019

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University's Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer.

2 Oct 2019

Wistar researcher receives NIH Director's Award to study link between diet, alcohol use and cancer

The National Institutes of Health today announced that Zachary T. Schug, Ph.D., assistant professor in the Molecular & Cellular Oncogenesis Program at The Wistar Institute, was awarded the prestigious NIH Director's New Innovator Award in support of his research on the link between a high sugar/fat diet, alcohol use and cancer.

1 Oct 2019

Electronic conversations between neurons could soon be recorded precisely

Electrodes are used to pick up electrical signals. Neurons however are tiny units of the nervous system and it is difficult to create an electrode small enough to record all the workings of a neurons.

24 Sep 2019

Newly synthesized anticancer compound can block cancer signaling mechanism

Of the various different functions that proteins perform in a cell, a crucial one is the recognition and transmission of certain "signals," collectively referred to as signal transduction.

24 Sep 2019

NIH grants totaling $2.8 million focus on pinpointing male fertility genes

Pinpointing the genes responsible for male fertility is the focus of two National Institutes for Health grants totaling $2.8 million.

20 Sep 2019

New device uses electromagnetic waves to reverse Alzheimer’s

A new study, to be published in the September 3, 2019, issue of the Journal of Alzheimer's Disease, provides something to cheer about for the estimated 44 million patients who have Alzheimer’s disease (AD) in the US, and their hard-pressed caregivers.

18 Sep 2019

GABA neurons affect the circadian clock

Researchers from Graduate School of Medicine, Nagoya University, Hokkaido University Graduate School of Medicine and Gunma University Graduate School of Medicine have collaborated to uncover the role of GABA-ergic neurons or the inhibitory neurons in the functioning of the central circadian clock of the body.

9 Sep 2019

Researchers discover role of GABA neurons in the central circadian clock

The research team led by Dr. Daisuke Ono and Prof. Akihiro Yamanaka of the Graduate School of Medicine, Nagoya University, collaborating with Prof. Ken-ichi Honma and Prof. Sato Honma of Hokkaido University Graduate School of Medicine, and Prof. Yuchio Yanagawa of Gunma University Graduate School of Medicine revealed that inhibitory neurons (GABAergic neurons) of the central circadian clock in the suprachiasmatic nucleus (SCN) refine circadian output rhythms.

8 Sep 2019

New insight and target for Alzheimer’s disease

The body is designed to fix anything that is out of balance. Homeostasis is maintained in the body, and even a minor change could trigger a compensatory mechanism, in the hopes of keeping everything stable.

4 Sep 2019

DNA methylation closely linked to telomere length

Aging is associated with multiple disease conditions. Recently it has been found that many of these illnesses are linked to the length of the telomeres at the ends of every chromosome. Telomere length (TL) is affected by both genetic and epigenetic contributions.

2 Sep 2019

New model system uses red blood cells to study malaria invasion

Researchers at the University of Bristol and Imperial College London have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.

29 Aug 2019

Intrinsic night vision could be on the horizon for humans

Scientists have used nanoparticles to develop the ability to see near-infrared light in mice.

29 Aug 2019

KAIST researchers describe new mechanism that induces self-killing of cancer cells

Researchers have described a new mechanism which induces the self-killing of cancer cells by perturbing ion homeostasis. A research team from the Department of Biochemical Engineering has developed helical polypeptide potassium ionophores that lead to the onset of programmed cell death.

29 Aug 2019

Intracellular News and Research

Discovery of 'cellular bike couriers' could shed light on disease spreading mechanisms

Researchers unveil ultrastructure of focal adhesion scaffold in pluripotent stem cells

SciLifeLab and AstraZeneca establish cryo-EM collaboration to advance biomedicine

Brain protein plays a prominent role in the maintenance of chronic pain

Kazan University researchers study the genetics of nephropathia epidemica

New link between two important products of nitric oxide discovered

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

Wistar researcher receives NIH Director's Award to study link between diet, alcohol use and cancer

Electronic conversations between neurons could soon be recorded precisely

Newly synthesized anticancer compound can block cancer signaling mechanism

NIH grants totaling $2.8 million focus on pinpointing male fertility genes

New device uses electromagnetic waves to reverse Alzheimer’s

GABA neurons affect the circadian clock

Researchers discover role of GABA neurons in the central circadian clock

New insight and target for Alzheimer’s disease

DNA methylation closely linked to telomere length

New model system uses red blood cells to study malaria invasion

Intrinsic night vision could be on the horizon for humans

KAIST researchers describe new mechanism that induces self-killing of cancer cells

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