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Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals - from fuels to fabrics and drugs - beyond the normal repertoire of microbes.

13 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

$78.4 million NIH grant supports Tufts CTSI to advance clinical and translational science research

Tufts Clinical and Translational Science Institute has received a $78.4 million Clinical and Translational Science Award from the NIH, the fourth consecutive grant since its founding in 2008.

10 Jun 2023

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity.

9 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Weak spot discovery could pave way for more effective cancer therapies

Prostate cancer is the most common non-skin cancer in men worldwide. According to international estimates about one in six men will get prostate cancer during their lifetime and worldwide, over 375'000 patients will die from it each year.

8 Jun 2023

ISSCR proposes new guidelines for using stem cells in research

The International Society for Stem Cell Research (ISSCR) today released the ISSCR Standards for Human Stem Cell Use in Research, an international collaboration aimed at enhancing rigor in preclinical research and ultimately strengthening the pipeline of therapies for patients.

6 Jun 2023

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Researchers investigate Nsp1 from SARS-CoV-2, MERS-CoV, and Bat-Hp-CoV using biophysical, structural, and biochemical assays.

5 Jun 2023

Cure Mito Foundation releases the first-of-its-kind online resource about Leigh syndrome

The Cure Mito Foundation, a parent-led organization dedicated to advancing research and treatments for Leigh syndrome, has launched the first-of-its-kind online resource about Leigh syndrome, the most common type of pediatric mitochondrial disease.

5 Jun 2023

Long-term side effects of modern treatment for rheumatoid arthritis

Janus kinase inhibitors (JAKi) and biologics are the cornerstone of modern treatment for rheumatoid arthritis (RA). But there have been concerns over long-term side effects.

1 Jun 2023

EULAR launches unique resource of facts and figures related to RMDs across Europe

The European Alliance of Associations for Rheumatology (EULAR) is proud to announce the launch of RheumaFacts, an innovative and unique resource of facts and figures related to rheumatic and musculoskeletal diseases (RMDs) across Europe.

1 Jun 2023

EULAR announces the launch of new survey targeted directly at RMD patients

The European Alliance of Associations for Rheumatology has announced the launch of the EULAR Impact of RMDs Survey, an online questionnaire targeted directly at RMD patients.

1 Jun 2023

Rheumatic and musculoskeletal diseases increase the risk of lethal comorbidities

Rheumatic and musculoskeletal diseases (RMDs) include over 200 diseases that affect over 120 million Europeans of all ages.

1 Jun 2023

Systematic approach needed to identify mental health issues in patients with inflammatory arthritis

Anxiety and depression are the mental health issues most commonly associated with inflammatory arthritis, and it is well-established that there is a link between mental health issues and poor health outcomes.

1 Jun 2023

Increased risk of cardiovascular disease in psoriatic arthritis patients

Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.

1 Jun 2023

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Researchers evaluated the potential of three licorice (Glycyrrhiza) species, i.e., G. glabra (GG), G. uralensis (GU), and G. infata (GI), and hops (Humulus lupulus), and their main bioactive polyphenols, to prevent breast malignancy.

1 Jun 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

Personalized video exercises may be useful to support rehabilitation for people with RMD

Apps have become ubiquitous in many parts of life, including for health. For people with an RMD, personalized video exercises (PEV) may be useful to support rehabilitation and physical exercise.

31 May 2023

Breaking barriers to improve access to quality information about lupus

In general, there is an issue around the quality of information about lupus on the internet. Rumors, unchecked data, and unconfirmed research all contribute to confusion and anxiety, and can lead to people taking the wrong actions for themselves and their disease.

31 May 2023

Translation News and Research

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Metformin shows promising antiviral activity against SARS-CoV-2

$78.4 million NIH grant supports Tufts CTSI to advance clinical and translational science research

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Weak spot discovery could pave way for more effective cancer therapies

ISSCR proposes new guidelines for using stem cells in research

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Cure Mito Foundation releases the first-of-its-kind online resource about Leigh syndrome

Long-term side effects of modern treatment for rheumatoid arthritis

EULAR launches unique resource of facts and figures related to RMDs across Europe

EULAR announces the launch of new survey targeted directly at RMD patients

Rheumatic and musculoskeletal diseases increase the risk of lethal comorbidities

Systematic approach needed to identify mental health issues in patients with inflammatory arthritis

Increased risk of cardiovascular disease in psoriatic arthritis patients

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Special issue aims to deepen the conversation around cerebral palsy

Personalized video exercises may be useful to support rehabilitation for people with RMD

Breaking barriers to improve access to quality information about lupus

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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