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Novel combination therapy slows cancer growth in patients with advanced solid tumors

A phase 1 clinical trial testing a novel combination therapy developed by scientists at VCU Massey Cancer Center slowed the growth of cancer in the majority of trial participants, which were patients with advanced solid tumors.

22 Jun 2016

Marketing authorisation for Penthrox handheld inhaler issued in France

Mundipharma International Limited today announced that Penthrox has been granted marketing authorisation in France for the emergency relief of moderate to severe pain in conscious adult patients with trauma and associated pain.

22 Jun 2016

Switch to rituximab shows anti-inflammatory effect in relapsing-remitting MS

Rituximab may be an attractive treatment option for patients with relapsing-remitting multiple sclerosis, suggest phase II study findings showing its efficacy in controlling inflammatory activity.

22 Jun 2016

New CAR-based therapy using combined cancer target could be effective for solid tumors

Chimeric antigen receptors (CARs), engineered from a patient's own immune cells, have been successful for treating blood cancers, but using CARs for solid tumors has been limited by side effects to normal tissues containing the protein targeted by the engineered cells.

22 Jun 2016

Lessons on personality changes can help mitigate stress, improve academic performance in teenagers

Teaching teens that social and personality traits can change helps them cope with social challenges such as bullying, which in turn can help mitigate stress and improve academic performance, according to a study by psychologists at The University of Texas at Austin.

21 Jun 2016

Apixaban effective in polypharmacy setting

The superiority of apixaban over warfarin in patients with atrial fibrillation is maintained in those taking multiple medications, shows further analysis of the ARISTOTLE trial.

21 Jun 2016

Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

The yellow fever vaccine given as one fifth of the regular dose could be used to control an outbreak in case of vaccine shortages.

20 Jun 2016

TUM researchers uncover molecular mechanism of thalidomide

In the 1950s, thalidomide (Contergan) was prescribed as a sedative drug to pregnant women, resulting in a great number of infants with serious malformations. Up to now, the reasons for these disastrous birth defects have remained unclear.

20 Jun 2016

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

17 Jun 2016

S1P1R variation may cause differential patient responses to fingolimod treatment

Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis.

16 Jun 2016

Surgical treatment more effective than medical therapy for treating severely obese adolescents

An analysis of the results of a study of bariatric surgery and a separate trial of medical therapy in treating type 2 diabetes in teenagers with severe obesity shows that after two years of treatment, body mass index (BMI) and HbA1c, a measure of blood sugar control, are both significantly better with surgery.

16 Jun 2016

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Adaptive Biotechnologies, the leader in combining next-generation sequencing (NGS) and expert bioinformatics to profile T- and B-cell receptors of the adaptive immune system, and collaborators will be presenting five studies demonstrating how Adaptive’s high-throughput sequencing platform enables diagnosis, detection and assessment of prognosis in hematological malignances and has increased sensitivity over flow cytometry.

16 Jun 2016

Neck device can protect sportsmen from devastating effects of head injuries

Two new studies involving high school football and hockey players indicate wearing a specifically designed compression collar around the neck may prevent or reduce the devastating effects of head collisions in sports.

16 Jun 2016

New analytical technology could improve cancer treatment by establishing ideal dosing regimens

University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond. Using mass spectrometry, an analytical instrument for sensitive detection and accurate

15 Jun 2016

Study characterizes benefits of over-the-counter sleep aid

New research shows that an over-the-counter sleep aid helps people suffering from occasional sleep difficulties fall asleep in less than 20 minutes, on average, and improves their reported quality of sleep.

15 Jun 2016

Veterinarian conducts clinical trials to improve cancer treatment for animals, humans

Raelene Wouda's passion for improving cancer treatment starts with our four-legged friends.

15 Jun 2016

IVR system with brief intervention message encourages patients to talk to doctors about drinking habits

Primary care doctors are reluctant to talk to patients about their drinking habits, for fear of being perceived as judgmental. But a simple, intervention that encourages discussion could resolve this issue, according to a recent study in the Journal of General Internal Medicine.

15 Jun 2016

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

An industry-driven consortium has developed a national roadmap designed to chart the path to large-scale manufacturing of cell-based therapeutics for use in a broad range of illnesses including cancer, neuro-degenerative diseases, blood and vision disorders and organ regeneration and repair.

15 Jun 2016

PharmaMar announces initiation of pivotal plitidepsin clinical trial in patients with T-cell lymphomas

PharmaMar today announced the start of a multicenter, prospective, pivotal study to analyze the efficacy of the antitumoral compound of marine origin, plitidepsin in patients with relapsed and refractory angioimmunoblastic T-cell lymphoma.

15 Jun 2016

Right ventricular echocardiography predicts targeted therapy outcome in PAH

Echocardiography re-assessment of right ventricular function after targeted therapy is sufficient to predict subsequent prognosis in patients with pulmonary arterial hypertension, say researchers.

15 Jun 2016

Efficacy News and Research

Novel combination therapy slows cancer growth in patients with advanced solid tumors

Marketing authorisation for Penthrox handheld inhaler issued in France

Switch to rituximab shows anti-inflammatory effect in relapsing-remitting MS

New CAR-based therapy using combined cancer target could be effective for solid tumors

Lessons on personality changes can help mitigate stress, improve academic performance in teenagers

Apixaban effective in polypharmacy setting

Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

TUM researchers uncover molecular mechanism of thalidomide

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

S1P1R variation may cause differential patient responses to fingolimod treatment

Surgical treatment more effective than medical therapy for treating severely obese adolescents

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Neck device can protect sportsmen from devastating effects of head injuries

New analytical technology could improve cancer treatment by establishing ideal dosing regimens

Study characterizes benefits of over-the-counter sleep aid

Veterinarian conducts clinical trials to improve cancer treatment for animals, humans

IVR system with brief intervention message encourages patients to talk to doctors about drinking habits

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

PharmaMar announces initiation of pivotal plitidepsin clinical trial in patients with T-cell lymphomas

Right ventricular echocardiography predicts targeted therapy outcome in PAH

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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