Genetic News and Research

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Genetic risk score can be used to determine risk of developing prostate cancer

Some racial and ethnic groups suffer relatively more often, and fare worse, from common ailments compared to others. Prostate cancer is one disease where such health disparities occur: risk for the disease is about 75 percent higher, and prostate cancer is more than twice as deadly, in Blacks compared to whites.

4 Jan 2021

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Treatment of depression faces two main challenges. The first is that almost 50% of patients do not respond well to existing antidepressants.

4 Jan 2021

Six clearly distinguishable subtypes of prediabetes identified

All prediabetes is not the same: in people in the preliminary stages of type 2 diabetes, there are six clearly distinguishable subtypes, which differ in the development of the disease, diabetes risk, and the development of secondary diseases.

4 Jan 2021

People with detectable brown fat less likely to suffer cardiac and metabolic conditions

Brown fat is that magical tissue that you would want more of. Unlike white fat, which stores calories, brown fat burns energy and scientists hope it may hold the key to new obesity treatments.

4 Jan 2021

FDA takes first steps in bringing clarity to emerging area of individualized drug development

Advances in scientific knowledge and drug development technology have provided an opportunity for new approaches to drug development, including the development of drugs for the treatment of rare diseases.

4 Jan 2021

Brain damage is not caused by direct COVID-19 attack, indicates study

n an in-depth study of how COVID-19 affects a patient's brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease.

3 Jan 2021

New UCLA-developed device transfers mitochondria into 100,000 or more recipient cells

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells.

29 Dec 2020

Brain scans predict posttraumatic stress disorder following mild TBI

Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder brought on by physical and/or psychological trauma. How its symptoms, including anxiety, depression and cognitive disturbances arise remains incompletely understood and unpredictable.

29 Dec 2020

Scientists trace genetic roots of Chiari 1 malformation

About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem.

28 Dec 2020

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

A new study led by clinician-scientists from the National Cancer Centre Singapore, with collaborators from research institutions worldwide, has found that angiosarcomas have unique genomic and immune profiles which allow them to be classified into three different subtypes.

28 Dec 2020

Polygenic risk scores from multi-population data could improve IBD predictions

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis. The study was published in Gastroenterology on December 24.

24 Dec 2020

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

COVID-19 antibodies preferentially target a different part of the virus in mild cases of COVID-19 than they do in severe cases, and wane significantly within several months of infection, according to a new study by researchers at Stanford Medicine.

24 Dec 2020

Gelatin hydrogel can be used in trophoblast spheroid motility assays, shows study

Trophoblast cells, which surround the developing blastocyst in early pregnancy, play an important role in implantation in the uterine wall.

24 Dec 2020

Researchers create a molecular catalog that describes different types of neurons

Retinal ganglion cells (RGCs) are the bottleneck through which all visual impressions flow from the retina to the brain. A team from the Max Planck Institute of Neurobiology, University of California Berkeley and Harvard University created a molecular catalog that describes the different types of these neurons.

24 Dec 2020

Genetic News and Research

Genetic risk score can be used to determine risk of developing prostate cancer

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Six clearly distinguishable subtypes of prediabetes identified

People with detectable brown fat less likely to suffer cardiac and metabolic conditions

FDA takes first steps in bringing clarity to emerging area of individualized drug development

Brain damage is not caused by direct COVID-19 attack, indicates study

New UCLA-developed device transfers mitochondria into 100,000 or more recipient cells

Brain scans predict posttraumatic stress disorder following mild TBI

Scientists trace genetic roots of Chiari 1 malformation

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

Polygenic risk scores from multi-population data could improve IBD predictions

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

Gelatin hydrogel can be used in trophoblast spheroid motility assays, shows study

Researchers create a molecular catalog that describes different types of neurons

New tool may help monitor serotonin transmission with greater fidelity than current methods

Researcher discovers seven DNA fingerprints that define cancer risk

Study presents novel gene therapy for deafness

Forward genetics used to identify gene linked to autism spectrum disorder

Health disparities in cancer and COVID-19 are caused by similar factors

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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