Immune System News and Research

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Less invasive infusion strategy not linked to cardiac functional improvements but enhances health status

A single dose of mesenchymal stem cells delivered intravenously to patients with chronic non-ischemic cardiomyopathy was not associated with significant cardiac structural or functional improvements, but did result in several clinically relevant benefits, according to results from a phase II-a randomized trial.

29 Aug 2016

Leading Chikungunya vaccine in clinical trial phase 2

With the first patient vaccinated, a Phase 2 clinical trial of a promising prophylactic vaccine candidate against Chikungunya fever has now commenced. The product is the most advanced Chikungunya vaccine candidate globally and is developed by the Austrian biotech company Themis Bioscience GmbH.

29 Aug 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Clinical trials and translational medicine have certainly given people hope and rapid pathways to cures for some of mankind's most troublesome diseases, but now is not the time to overlook the power of basic research, says UC Santa Barbara neuroscientist Kenneth S. Kosik.

27 Aug 2016

Penn State dermatologist clarifies common myths about psoriasis

Psoriasis is a much-misunderstood disease, often kept under wraps by sufferers who want to hide their skin lesions.

26 Aug 2016

Fiocruz to start phase II clinical trials of novel vaccine for schistosomiasis

The Oswaldo Cruz Foundation at Rio de Janeiro, Brazil, will start the phase II clinical trials of a vaccine for schistosomiasis, called 'Sm14 Vaccine'.

26 Aug 2016

Paleo diet may be beneficial for heart health

The popular Paleo diet is based on eating foods thought to be available to our ancestors during the Paleolithic era, before the advent of dairy or processed grains.

26 Aug 2016

Researchers engineer protein-shelled nanostructures useful for ultrasound imaging

Ultrasound imaging is used around the world to help visualize developing babies and diagnose diseases. Sound waves bounce off the tissues, revealing their different densities and shapes.

26 Aug 2016

New drug delivery system slows and controls tumors not aiming for complete elimination

Researchers have created a new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment - to dramatically slow and control tumors on a long-term, sustained basis, not necessarily aiming for their complete elimination.

26 Aug 2016

IRB Barcelona review article provides insights into emerging field of shuttle peptides

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently.

26 Aug 2016

Naturally-occurring sugars in woman's breast milk may protect infants against life threatening bacteria

A type of sugar found naturally in some women's breast milk may protect newborn babies from infection with a potentially life threatening bacterium called Group B streptococcus, according to a new study from Imperial College London.

26 Aug 2016

NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

Microglia are cells that combat various brain diseases and injuries by swallowing foreign or disruptive objects and releasing molecules that activate repair mechanisms.

26 Aug 2016

Study finds age-dependent differences in expression of allergy to dust mites

In adults with a house dust mite allergy, a cascade of inflammatory signals on the surface of the airways leads to airway remodeling.

26 Aug 2016

Majority of cancers can be caused by infectious agents in sub-Saharan Africa, reveals study

In 1963, Irish surgeon Denis Parson Burkitt airmailed samples of an unusual jaw tumor found in Ugandan children to his colleague, Anthony Epstein, at Middlesex Hospital in London.

26 Aug 2016

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

A study shows that stimulating the production of interleukin-17A (IL-17A), one of the cytokines released by cells of the immune system, can be an effective strategy for the treatment of visceral leishmaniasis, considered one of the six most important parasitic diseases affecting humans.

25 Aug 2016

Curbing immune system infighting could make treatment more effective for pancreatic cancer

Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer.

25 Aug 2016

Cedars-Sinai study identifies metabolic enzyme that alerts the body to invading bacteria

Biomedical investigators at Cedars-Sinai have identified an enzyme found in all human cells that alerts the body to invading bacteria and jump-starts the immune system.

25 Aug 2016

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New research has shown how a cell surface molecule, Lymphotoxin β receptor, controls entry of T-cells into the thymus; and as such presents an opportunity to understanding why cancer patients who undergo bone-marrow transplant are slow to recover their immune system.

25 Aug 2016

Three like-minded nonprofits collaborate to launch immunotherapy clinical trial for pediatric brain tumors

A Kids' Brain Tumor Cure Foundation, Solving Kids' Cancer and the Ty Louis Campbell Foundation announce their joint financial support of a Phase 1 clinical trial to test the safety and efficacy of combination checkpoint inhibitors in the treatment of children with brain tumors.

25 Aug 2016

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania.

25 Aug 2016

Immune System News and Research

Less invasive infusion strategy not linked to cardiac functional improvements but enhances health status

Leading Chikungunya vaccine in clinical trial phase 2

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Penn State dermatologist clarifies common myths about psoriasis

Fiocruz to start phase II clinical trials of novel vaccine for schistosomiasis

Paleo diet may be beneficial for heart health

Researchers engineer protein-shelled nanostructures useful for ultrasound imaging

New drug delivery system slows and controls tumors not aiming for complete elimination

IRB Barcelona review article provides insights into emerging field of shuttle peptides

Naturally-occurring sugars in woman's breast milk may protect infants against life threatening bacteria

NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

Study finds age-dependent differences in expression of allergy to dust mites

Majority of cancers can be caused by infectious agents in sub-Saharan Africa, reveals study

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

Curbing immune system infighting could make treatment more effective for pancreatic cancer

Cedars-Sinai study identifies metabolic enzyme that alerts the body to invading bacteria

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

Three like-minded nonprofits collaborate to launch immunotherapy clinical trial for pediatric brain tumors

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

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