Gastroenterology News and Research

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Gastroenterology is the branch of medicine where the digestive system and its disorders are studied.

Kidney disease risk gene found in more populations than previously known

In the largest population genomics investigation to date, a team of researchers at the Icahn School of Medicine at Mount Sinai, Stanford University, and the University of Colorado have discovered that kidney disease risk variants of the gene APOL1, previously known to affect African and African American populations, are also found at appreciable frequencies in Caribbean and Latin American populations.

28 Dec 2018

Kanazawa University researchers unravel link between inflammation and cancer

Severe inflammation in tissues is often associated with the occurrence of cancer. The mechanism linking both these conditions is not clearly understood. Furthermore, inflamed and cancerous tissues contain a heterogenous mix of damaged and protective cells.

27 Dec 2018

Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

In the largest genetic analysis of polycystic ovary syndrome (PCOS) performed to date, an international consortium, including researchers at the Icahn School of Medicine at Mount Sinai, conducted a whole genome association study to identify common genetic architecture for different diagnostic criteria used to define the syndrome.

24 Dec 2018

Change in genome of Caucasians could explain higher rates of esophageal cancer

A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds.

21 Dec 2018

Split liver transplants could save children on wait list finds study

A review analysed 5,300 cases of liver transplants on children across the country. The team of researchers from the Johns Hopkins Medicine looked at the patients who were more likely to survive after a split liver transplant. A split liver transplant is a type of transplant where the recipient receives only a part of the donor’s liver.

18 Dec 2018

Sickest children could benefit from split liver transplants

In a review of registry data for more than 5,300 liver transplants performed in children nationwide, Johns Hopkins Medicine researchers identify the type of patient who is most likely to survive a split liver transplant--receiving only part of a donor's liver--with no additional long-term health risks, which could allow for an increase in the availability of organs.

18 Dec 2018

Study: Loss of tight junction barrier protein results in gastric cancer development

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer.

13 Dec 2018

New collaborative partnership in quest of novel antibiotics

The Global Antibiotic Research and Development Partnership, Eisai Co., Ltd. and Takeda Pharmaceutical Company Limited have signed an agreement for GARDP to access and screen components of Eisai and Takeda's chemical libraries.

12 Dec 2018

Researchers develop new system for efficiently producing human norovirus

An Osaka University-led research team has developed a system for simply and efficiently producing human norovirus. By coaxing human induced pluripotent stem cells to develop into a type of cell that usually lines the intestine, they created a cellular environment that can be used for producing the virus, studying how it interacts with human cells, and investigating potential vaccines.

11 Dec 2018

Researchers capture high-resolution X-ray and NMR image of key immune regulator

A new study by investigators from Brigham and Women's Hospital provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 (hTIM-3).

11 Dec 2018

Mount Sinai researcher awarded $2.5 million to advance understanding of neurodegenerative diseases

Ivan Marazzi, PhD, Assistant Professor of Microbiology at the Icahn School of Medicine at Mount Sinai, was awarded $2.5 million in funding by the Chan Zuckerberg Initiative to further the understanding of the underlying causes of neurodegenerative disorders such as Lou Gehrig's, Alzheimer's, and Parkinson's diseases. The

7 Dec 2018

Online CBT can help treat gastrointestinal disorders in children

Cognitive behavioral therapy online can be useful in treating gastrointestinal disorders in children when no physical cause can be found. This is the viewpoint of researchers at Karolinska Institutet in Sweden that is described in a new study published in the journal Clinical Gastroenterology and Hepatology.

7 Dec 2018

Proton pump inhibitors in combination with oral anticoagulants reduce GI bleeding risk

A Vanderbilt University Medical Centerstudy published today in JAMA shows that patients already at higher risk for gastrointestinal bleeding gain a marked protection from this risk when they take a proton pump inhibitor in combination with an oral anticoagulant.

4 Dec 2018

Sema4, Mount Sinai, Sanofi announce launch of new collaborative asthma study

Sema4, a patient-centered predictive health company, and the Mount Sinai Health System today announced the launch of a five-year collaborative study with Sanofi designed to provide new insights into the biological mechanisms and other factors implicated in asthma.

4 Dec 2018

ICUS applauds announcement of dramatic changes in payment for contrast-enhanced ultrasound imaging

The International Contrast Ultrasound Society (ICUS) applauds the announcement of dramatic changes in payment for contrast-enhanced ultrasound (CEUS) imaging of the abdomen.

27 Nov 2018

Gut-directed hypnotherapy may offer new treatment option for IBS patients

Gut-directed hypnotherapy delivered by psychologists appears as effective in group or individual sessions, potentially offering a new treatment option for irritable bowel syndrome in primary and secondary care.

23 Nov 2018

Live probiotics can change existing gut flora and alter immune response

New research published in the International Journal of Pharmaceutics demonstrates that 'good' bacteria in the live probiotic SymproveTM can successfully reach and colonize the gut, where they go on to change the existing gut flora. They are also capable of modifying immune response.

20 Nov 2018

Study evaluates second-hand marijuana smoke exposure among children

In a study designed to evaluate second-hand marijuana smoke exposure among children--a topic that scientists have not yet widely addressed--researchers at the Icahn School of Medicine at Mount Sinai found that nearly half of children whose parents smoked marijuana showed evidence of second-hand marijuana smoke exposure.

20 Nov 2018

Purified omega-3 and aspirin reduce pre-cancerous bowel polyps, shows study

Both aspirin and a purified omega-3, called EPA, reduce the number of pre-cancerous polyps in patients found to be at high risk of developing bowel cancer, according to new research.

20 Nov 2018

Report reveals increase in pancreatic cancer death rates across Europe

Pancreatic cancer death rates in the European Union have increased by 5% between 1990 and 2016, a report launched today reveals. This is the highest increase in any of the EU’s top five cancer killers which, as well as pancreatic cancer, includes lung, colorectal, breast and prostate cancer.

15 Nov 2018