Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Cellular mechanophenotyping may provide more comprehensive view of the tumor

Our ability to predict who will get cancer, how a patient will respond to treatment, or if a patient will relapse is still quite limited. Despite advances in the detection of genetic mutations and the establishment of risk factors, such as age and genetic variants, it remains a great scientific and medical challenge.

9 Jun 2020

Study reveals outcomes of radiosurgery for patients with brain metastases from small cell lung cancer

The international First-line Radiosurgery for Small-Cell Lung Cancer analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology details clinical outcomes for 710 patients with brain metastases from small cell lung cancer treated with first-line stereotactic radiosurgery, without prior treatment with whole-brain radiation or prophylactic cranial irradiation.

5 Jun 2020

New analysis supports first-line stereotactic radiosurgery for small cell lung cancer

The international First-line Radiosurgery for Small-Cell Lung Cancer (FIRE-SCLC) analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology details clinical outcomes for 710 patients with brain metastases from small cell lung cancer treated with first-line stereotactic radiosurgery (SRS), without prior treatment with whole-brain radiation (WBRT) or prophylactic cranial irradiation (PCI).

5 Jun 2020

Gleason grade group 5 prostate cancer can be divided into subtypes with distinct differences

Researchers at the UCLA Jonsson Comprehensive Cancer Center analyzed gene-expression patterns in the most aggressive prostate cancer grade group -- known as Gleason grade group 5 -- and found that this grade of cancer can actually be subdivided into four subtypes with distinct differences.

4 Jun 2020

Nicotine promotes spread of lung cancer cells into the brain, study finds

Researchers at Wake Forest School of Medicine have discovered that nicotine promotes the spread of lung cancer cells into the brain, where they can form deadly metastatic tumors.

4 Jun 2020

Researchers examine the role of two genes that cause triple-negative breast cancer

Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow.

3 Jun 2020

Fraunhofer researchers investigate the mechanisms of metastasis formation

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation - and searching for approaches for new treatments in the fight against cancer.

2 Jun 2020

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Scientific evidence suggests that cancer can metastasize to other organs when either a single cell or a cluster of cells detaches from the original tumor and travels through the blood to another location, where it grows into a new tumor.

1 Jun 2020

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Patients with advanced non-small cell lung cancer (NSCLC) and the MET exon 14 (METex14) skipping mutation had a 46.5% objective response rate to the targeted therapy drug tepotinib, as shown in a study published today in the New England Journal of Medicine and presented at the 2020 American Society of Clinical Oncology Annual Meeting ASCO20 Virtual Meeting (Abstract 9556 - Poster 322) by researchers from The University of Texas MD Anderson Cancer Center.

29 May 2020

Ludwig Cancer Research study profiles immune landscape of brain tumors

A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

28 May 2020

Inhibiting tumor signals can suppress the spread of cancer

For most people who die of cancer, the spread of the initial tumor is to blame. "Metastasis is what kills most cancer patients," says Serge Fuchs, a professor in Penn's School of Veterinary Medicine.

28 May 2020

A new approach to predict the evolutionary mechanisms of melanoma

Melanoma is a malignant tumour resulting from the transformation of melanocytes, the cells in the skin that undertake to synthesise melanin, a complex polymer which protects us from the negative effects of solar radiation.

27 May 2020

Lymph node and distant metastases develop through different evolutionary mechanisms, study shows

The evolutionary processes underlying metastasis-the development of secondary malignant growths away from the primary tumor site-in human patients are still incompletely understood.

26 May 2020

Inherited genetic variations can alter progression of melanoma, indicates study

Sometimes cancer stays put, but often it metastasizes, spreading to new locations in the body. It has long been suspected that genetic mutations arising inside tumor cells drive this potentially devastating turn of events.

26 May 2020

New therapeutic approach for aggressive breast cancer

This type of TNBC tumor does not express any of the receptors involved in most breast cancers (estrogen, progesterone and HER2), so the most common treatments, such as the hormone therapy, are not viable in these patients.

25 May 2020

Study shows how cancer protein changes may accelerate tumorigenesis and metastasis

Understanding the genetic mutations and protein changes that take place in the progression of cancer is key to its treatment. Mutations in the gene TP53 and concomitant mutant p53 proteins in cancer cells have become notorious over the course of multiple studies of several different types of cancers.

18 May 2020

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

For years, surgeons have operated on pancreatic cancer patients to remove what they thought was a localized tumor only to discover that the disease had spread to other, inoperable parts of the body. Now, a City of Hope molecular scientist thinks he may have found a way to prevent ineffective surgeries and prolong the lives of these patients.

18 May 2020

A new tool to study and map the intricacies of intercellular signaling

How do cells move? Why do they move? Why do some cancer cells move slowly while others move quickly, causing a cancerous tumor to metastasize and become much more difficult to treat effectively?

18 May 2020

Scientists describe new mechanism of cellular locomotion

Whilst the whole world is in lockdown during the current Corona crisis, certain cells within our bodies are still travelling long-distance: while this happens when you develop pneumonia, any ordinary cut on your finger will also trigger white blood cells--aka leukocytes--to instantly move out of your blood vessels into the site of inflammation.

14 May 2020

Researchers identify new therapeutic target to switch-off cancer stem cells

Tumors are not a uniform mass of cells. Colon cancers bear differentiated-like cells, similar to the functional cells of the intestinal wall, and pluripotent cells--the so-called tumour stem cells.

13 May 2020

Metastasis News and Research

Further Reading

Cellular mechanophenotyping may provide more comprehensive view of the tumor

Study reveals outcomes of radiosurgery for patients with brain metastases from small cell lung cancer

New analysis supports first-line stereotactic radiosurgery for small cell lung cancer

Gleason grade group 5 prostate cancer can be divided into subtypes with distinct differences

Nicotine promotes spread of lung cancer cells into the brain, study finds

Researchers examine the role of two genes that cause triple-negative breast cancer

Fraunhofer researchers investigate the mechanisms of metastasis formation

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Ludwig Cancer Research study profiles immune landscape of brain tumors

Inhibiting tumor signals can suppress the spread of cancer

A new approach to predict the evolutionary mechanisms of melanoma

Lymph node and distant metastases develop through different evolutionary mechanisms, study shows

Inherited genetic variations can alter progression of melanoma, indicates study

New therapeutic approach for aggressive breast cancer

Study shows how cancer protein changes may accelerate tumorigenesis and metastasis

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

A new tool to study and map the intricacies of intercellular signaling

Scientists describe new mechanism of cellular locomotion

Researchers identify new therapeutic target to switch-off cancer stem cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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