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Suppressing STARD9 protein could be a novel strategy to fight cancers

Suppressing a newly identified and characterized protein involved in regulating cell division could be a novel strategy to fight certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers with UCLA's Jonsson Comprehensive Cancer Center.

12 Dec 2011

Researchers shown how BRCA1 inactivation raises cancer risk

Working with human breast cells, researchers at the Johns Hopkins Kimmel Cancer Center have shown how the inactivation of a single copy of the breast cancer gene BRCA1 leaves breast cells vulnerable to cancer by reducing their ability to repair DNA damage, causing genetic instability.

12 Dec 2011

Obese women with early-stage HER2-positive breast cancer may have poorer outcomes

Obese patients with early-stage HER2-positive breast cancer may have worse outcomes than patients who are normal weight or overweight, Mayo Clinic researchers found in a study presented today at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. HER2-positive breast cancer gets its name from a protein called human epidermal growth factor receptor 2 that promotes cancer cell growth.

12 Dec 2011

HER2 proteins do not predict breast cancer patient's outcome after Herceptin treatment

Precisely quantifying the amount of three different HER growth proteins, along with several other proteins believed linked to breast cancer, did not predict a patient's outcome after treatment for HER2-Positive Breast Cancer with Herceptin, say Mayo Clinic researchers.

12 Dec 2011

Gene therapy can reduce painful bleeding episodes in patients with hemophilia B

Symptoms improved significantly in adults with the bleeding disorder hemophilia B following a single treatment with gene therapy developed by researchers at St. Jude Children's Research Hospital in Memphis and demonstrated to be safe in a clinical trial conducted at the University College London (UCL) in the U.K.

12 Dec 2011

New method to design Alzheimer's antibodies

Researchers at Rensselaer Polytechnic Institute have developed a new method to design antibodies aimed at combating disease. The surprisingly simple process was used to make antibodies that neutralize the harmful protein particles that lead to Alzheimer's disease.

12 Dec 2011

Breast cancer hope with new drug and new combination regimens

last week at the San Antonio Breast Cancer Symposium, researchers announced encouraging results from studies of two cancer medications that appeared to keep breast cancer from advancing.

11 Dec 2011

Increased sensitivity to low frequency vibration found in people with inherited hearing loss

People with a certain form of inherited hearing loss have increased sensitivity to low frequency vibration, according to a study by Professor Thomas Jentsch of the Leibniz-Institut f-r Molekulare Pharmakologie (FMP)/Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch and Professor Gary Lewin (MDC), conducted in cooperation with clinicians from Madrid, Spain and Nijmegen, the Netherlands.

9 Dec 2011

Study explains molecular basis for cherubism disease

The Samuel Lunenfeld Research Institute's Drs. Frank Sicheri, Tony Pawson and Sebastian Guettler, in collaboration with Dr. Robert Rottapel at the Ontario Cancer Institute, have uncovered the detailed architecture of a crucial component of Tankyrase, a protein linked to the bone development disorder cherubism and involved in a myriad of cellular processes.

9 Dec 2011

Experimental sublingual vaccine shows promise against influenza infection

Scientists from the International Vaccine Institute (IVI) have discovered that an antigen common to most influenza viruses, and commonly referred to as matrix protein 2 (M2), when administered under the tongue could protect mice against experimental infection caused by various influenza viruses, including the highly pathogenic avian H5 virus and the pandemic H1 ("swine flu") virus.

9 Dec 2011

Researchers discover potential target for cherubism

Cancer researchers studying genetic mutations that cause leukemia have discovered a connection to the rare disease cherubism, an inherited facial bone disorder in children.

9 Dec 2011

caprotec's CCMS technology identifies novel co-targets of three anti-cancer drugs

caprotec bioanalytics GmbH announced today the discovery of previously unknown specific drug-protein interactions for several anti-cancer drugs and the identification of potential novel co-targets of the drug molecules through the use of company's CCMS technology.

9 Dec 2011

Genetically identical Salmonella appear in 2 types, each with an infective advantage

An unusual regulatory mechanism that controls the swimmer/non-swimmer option in genetically identical Salmonella also impacts the bacteria's ability to cause infection.

9 Dec 2011

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Cancer Research UK-funded scientists at The Institute of Cancer Research (ICR) have revealed a technique to kill chronic myeloid leukaemia (CML) cells that have stopped responding to a targeted drug, according to research published in Cancer Cell today.

9 Dec 2011

Scientists discover mechanism that controls 'fat switch' in the body

Scientists at Warwick Medical School have made an important discovery about the mechanism controlling the body's 'fat switch', shedding new light on our understanding of how proteins regulate appetite control and insulin secretion.

9 Dec 2011

Mystery of unpleasant tough texture in vegetable oil-cooked hot dogs

In part of an effort to replace animal fat in hot dogs, sausages, hamburgers and other foods with healthier fat, scientists are reporting an advance in solving the mystery of why hot dogs develop an unpleasant tough texture when vegetable oils pinch hit for animal fat. A report on their study appears in ACS' Journal of Agricultural and Food Chemistry.

8 Dec 2011

H. pylori bacterium produces urease to neutralize gastric acid

A research team led by scientists at the Chinese University of Hong Kong is releasing study results this week showing how a bacterium, Helicobacter pylori, that causes more than half of peptic ulcers worldwide and that has been implicated in stomach cancer has managed for eons to turn the acidic environment of the human gut into one in which it can thrive.

8 Dec 2011

New gene editing technique can heal sickle cell patients with their own cells

Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

8 Dec 2011

Researchers determine planar nets to build self-assembling 3-D structures

Material chemists and engineers would love to figure out how to create self-assembling shells, containers or structures that could be used as tiny drug-carrying containers or to build 3-D sensors and electronic devices.

8 Dec 2011

Animal study offers insights into possible drug targets to improve memory as we age

Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study in the December 7 issue of The Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.

8 Dec 2011

G Protein News and Research

Suppressing STARD9 protein could be a novel strategy to fight cancers

Researchers shown how BRCA1 inactivation raises cancer risk

Obese women with early-stage HER2-positive breast cancer may have poorer outcomes

HER2 proteins do not predict breast cancer patient's outcome after Herceptin treatment

Gene therapy can reduce painful bleeding episodes in patients with hemophilia B

New method to design Alzheimer's antibodies

Breast cancer hope with new drug and new combination regimens

Increased sensitivity to low frequency vibration found in people with inherited hearing loss

Study explains molecular basis for cherubism disease

Experimental sublingual vaccine shows promise against influenza infection

Researchers discover potential target for cherubism

caprotec's CCMS technology identifies novel co-targets of three anti-cancer drugs

Genetically identical Salmonella appear in 2 types, each with an infective advantage

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Scientists discover mechanism that controls 'fat switch' in the body

Mystery of unpleasant tough texture in vegetable oil-cooked hot dogs

H. pylori bacterium produces urease to neutralize gastric acid

New gene editing technique can heal sickle cell patients with their own cells

Researchers determine planar nets to build self-assembling 3-D structures

Animal study offers insights into possible drug targets to improve memory as we age

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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