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Study examines impact of tobacco smoke carcinogen on mice

Although tobacco use is widely understood to be one of the leading causes of oral cancer, research on the prevention of tobacco-related oral cancer in experimental animals has traditionally been limited to examining the impact of synthetic carcinogens manufactured especially for cancer research, rather than on observing the effects of carcinogens that occur in tobacco smoke.

14 May 2010

Each melanoma cell capable of cancer stem cell behavior: Study

Scientists at The Wistar Institute offer a new explanation for the persistent ability of melanoma cells to self-renew, one of the reasons why melanoma remains the deadliest form of skin cancer. The concept of the "dynamic stemness" of melanoma can explain why melanoma cells behave like both conventional tumor cells and cancer stem cells.

14 May 2010

ISCA recommends chromosomal microarray as new standard for genetic evaluation of children

An international consortium of genetics experts has issued a consensus statement recommending chromosomal microarray (CMA) as the new standard practice for genetic evaluation of children with unexplained developmental delay, autism or birth defects.

14 May 2010

Report of 2009 H1N1 influenza VLP vaccine published online

Novavax, Inc. announces the first report of a vaccine protecting ferrets against the 2009 pandemic H1N1 virus has been published in the journal Vaccine May 12, 2010 online issue.

14 May 2010

Response Genetics first-quarter total revenue up 140%

Response Genetics Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, today announced its consolidated financial results for the three months ended March 31, 2010.

14 May 2010

Cyclacel Pharmaceuticals reports net loss of $5.1M for first-quarter 2010

Cyclacel Pharmaceuticals, Inc., a biopharmaceutical company developing oral therapies that target the various phases of cell cycle control for the treatment of cancer and other serious disorders, today reported its financial results and business highlights for the first quarter ended March 31, 2010.

14 May 2010

Clinical Data expands PGxHealth's FAMILION tests to include two new tests to diagnose heart diseases

Clinical Data, Inc., announced today that its PGxHealth division is expanding its FAMILION family of genetic tests to include two new tests to diagnose heart diseases. With the launch of a test for Conduction Disease associated with Dilated Cardiomyopathy and a test for Short QT Syndrome, PGxHealth continues to lead the industry with the most comprehensive menu of genetic tests to diagnose or confirm familial heart diseases.

12 May 2010

Mutations in STRAD-alpha gene can cause PMSE syndrome in Amish children: Penn researchers

So often the rare informs the common. Penn researchers investigating a regulatory protein involved in a rare genetic disease have shown that it may be related to epileptic and autistic symptoms in other more common neurological disorders.

12 May 2010

Genetic tests represent future of cancer care for women

Important progress is being made in women's health through the use of genetic tests, particularly those that help women detect and treat cancer.

12 May 2010

Mutation causing light chain amyloidosis identified

Light chain amyloidosis, a deadly protein misfolding disease, is caused by multiple mutations in cells that are intended to protect the body. Instead, the mutations send misfolded bundles of proteins through the bloodstream, potentially destroying the heart, kidneys, liver or other organs. Mayo Clinic researchers have identified one of these mutations and have shown that the molecule's shifting position is as important as its unique shape. The findings appear in the current issue of the journal Structure.

12 May 2010

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

Response Genetics, Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, today announced it has signed a non-exclusive license agreement with GlaxoSmithKline ("GSK"). Under the terms of the agreement, GSK gains certain rights to Response Genetics' proprietary PCR analysis technology and diagnostic expertise to assess BRAF gene mutations in human tumor samples. Payments will be made to Response Genetics upon achivement of agreed-to milestones.

12 May 2010

Prenatal screening, genetic counseling essential for preventing alpha-thalassemia: Researchers

Researchers from Mahidol University have developed a rapid, high-throughput screening method for prevention and control of thalassemia. The related report by Munkongdee et al, "Rapid diagnosis of α-thalassemia by melting curve analysis," appears in the May 2010 issue of The Journal of Molecular Diagnostics.

12 May 2010

Amorfix, Epitomics collaborate to develop high-affinity monoclonal antibodies against cancer targets

Amorfix Life Sciences and Epitomics, Inc. announced today that they have entered into an agreement to develop high-affinity monoclonal antibodies against a number of targets for cancer. Amorfix has identified several disease specific epitopes (DSEs) on misfolded proteins with their proprietary ProMIS(TM) computational platform discovery technology, which will be used by Epitomics to generate highly specific monoclonal antibodies (mAbs).

11 May 2010

New multicenter trial achieves 71% survival in AML children

More individualized therapy and better supportive care helped push the survival for children with acute myeloid leukemia (AML) to 71 percent three years after diagnosis, according to new research led by St. Jude Children's Research Hospital investigators and reported in the medical journal The Lancet Oncology. The survival rate of 71 percent is 20 percent better than previously reported U.S. rates and is similar to the success achieved in a 2009 Japanese study, said Jeffrey Rubnitz, M.D., Ph.D., a member of the St. Jude Oncology department.

11 May 2010

SNP biomarker could reduce guesswork associated with prescribing drugs

A tiny gene mutation in human liver cells could one day influence how high or low a dose patients need of about half of the clinically used drugs on the market, new research suggests.

11 May 2010

Research may aid in developing new cancer therapies

Immortality and uncontrolled cell division are the fundamental differences between cancer cells and normal cells.

11 May 2010

UC San Diego researchers discover potential new treatment for familial adenomatous polyposis

A team of University of California, San Diego School of Medicine researchers has discovered that common intestinal bacteria appear to promote tumor growths in genetically susceptible mice, but that tumorigenesis can be suppressed if the mice are exposed to an inhibiting protein enzyme.

10 May 2010

UT Southwestern offers advanced lung-cancer patients free screenings of tumors for genetic mutations

UT Southwestern Medical Center is the only site in North Texas participating in a national study that offers advanced lung-cancer patients free screenings of their tumors for genetic mutations, some of which might be targets for treatment with existing or experimental therapies.

10 May 2010

UT Southwestern researchers uncover core function of gene involved in Fragile X syndrome

Researchers at UT Southwestern Medical Center have discovered how the genetic mutation that causes Fragile X syndrome, the most common form of inherited mental retardation, interferes with the "pruning" of nerve connections in the brain. Their findings appear in the April 29 issue of Neuron.

10 May 2010

Animal study reveals intestinal bacteria can promote tumor growth

10 May 2010

Mutation News and Research

Study examines impact of tobacco smoke carcinogen on mice

Each melanoma cell capable of cancer stem cell behavior: Study

ISCA recommends chromosomal microarray as new standard for genetic evaluation of children

Report of 2009 H1N1 influenza VLP vaccine published online

Response Genetics first-quarter total revenue up 140%

Cyclacel Pharmaceuticals reports net loss of $5.1M for first-quarter 2010

Clinical Data expands PGxHealth's FAMILION tests to include two new tests to diagnose heart diseases

Mutations in STRAD-alpha gene can cause PMSE syndrome in Amish children: Penn researchers

Genetic tests represent future of cancer care for women

Mutation causing light chain amyloidosis identified

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

Prenatal screening, genetic counseling essential for preventing alpha-thalassemia: Researchers

Amorfix, Epitomics collaborate to develop high-affinity monoclonal antibodies against cancer targets

New multicenter trial achieves 71% survival in AML children

SNP biomarker could reduce guesswork associated with prescribing drugs

Research may aid in developing new cancer therapies

UC San Diego researchers discover potential new treatment for familial adenomatous polyposis

UT Southwestern offers advanced lung-cancer patients free screenings of tumors for genetic mutations

UT Southwestern researchers uncover core function of gene involved in Fragile X syndrome

Animal study reveals intestinal bacteria can promote tumor growth

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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