Efficacy News and Research

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AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will report new clinical trial and scientific data from their industry-leading lung cancer franchise of marketed and pipeline medicines at the European Lung Cancer Conference in Geneva, Switzerland, 13 -16 April 2016.

11 Apr 2016

Researchers identify severe side effects of Clozapine drug

Clozapine (CLZ) is a "gold standard" drug for managing treatment-resistant schizophrenia (TRS), who do not respond adequately to first-line antipsychotics.

7 Apr 2016

Shortened RT schedule has similar efficacy as conventional RT schedule in low-risk prostate cancer patients

Of the more than 220,000 patients newly diagnosed with prostate cancer in 2015, the vast majority will have had early-stage disease at low risk for recurrence.

7 Apr 2016

Ludwig, CRI launch Phase 1/2 trial of combination immunotherapy for advanced ovarian cancer

Ludwig Cancer Research and the Cancer Research Institute have launched a Phase 1/2 clinical trial of combination immunotherapy for advanced ovarian cancer. The international, multicenter trial is led by George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne and Brad Monk, director of Gynecologic Oncology at St. Joseph's Hospital and Medical Center.

7 Apr 2016

Clinical pharmacists in health care teams may improve quality, safety of patient care

Problems related to elderly patients' medical drug treatments are widespread and commonly result in hospital admissions for people with dementia. New research shows that including clinical pharmacists in health care teams might improve the quality and safety of patient care and halve the risk of drug-related hospital readmissions. This according to a dissertation at Umea University in Sweden.

6 Apr 2016

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Nonalcoholic fatty liver disease, or NAFLD, comprises a group of liver disorders whose prevalence is widespread and rising. It's estimated that at least one-third of Americans have NAFLD; among obese persons, the figure is 50 percent.

6 Apr 2016

Immune-boosting formulation in Chinese herbal remedies comes from bacteria growing on Angelica roots

Juzen-taiho-to, also known as shi quan da bu tang, is one of the most popular herbal formulas in China and Japan and is used in the West by practitioners of traditional Asian medicine. New research suggests the remedy's immune-boosting effects are due, at least in part, to bacteria that grow on the roots of one of the formula's component herbs.

6 Apr 2016

New technologies can improve memory, learning in cognitive deficit patients

People are using brain-machine interfaces to restore motor function in ways never before possible - through limb prosthetics and exoskletons. But technologies to repair and improve cognition have been more elusive. That is rapidly changing with new tools - from fully implantable brain devices to neuron-eavesdropping grids atop the brain - to directly probe the mind.

6 Apr 2016

New neurological mechanism can contribute to pain reduction

A UT Dallas scientist has found a new neurological mechanism that appears to contribute to a reduction in pain.

5 Apr 2016

Losmapimod drug fails to meet primary endpoint in clinical trial

Patients taking losmapimod, an anti-inflammatory drug currently being developed, for 12 weeks following a heart attack did not show improvements in the trial's primary endpoint, the rate of cardiovascular death, subsequent heart attack or urgent coronary revascularization, which includes placement of a stent or coronary artery bypass surgery, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

5 Apr 2016

Scientists successfully turn off misbehaving protein that fuels growth of triple-negative breast cancer

Working with human breast cancer cells, a team of scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have successfully turned off a misbehaving protein that fuels the growth of a particularly aggressive, drug-resistant form of the disease known as triple-negative breast cancer.

5 Apr 2016

Magnesium could be safe, cost-effective therapeutic intervention for genetic coagulation disorder

An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process. Scientists of the Rudolf Virchow Center and the Hospital of the University of Würzburg were primarily involved in this study. Their results were published in the current journal "Nature Communications".

4 Apr 2016

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Findings from the early phase of a clinical trial led by Johns Hopkins investigators indicates that a new, minimally invasive weight loss treatment known as bariatric arterial embolization is safe and effective in sustaining weight loss in severely obese people.

4 Apr 2016

Combining aromatase inhibitors with growth hormone may help short adolescent boys grow taller

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests. The study results will be presented Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society in Boston.

4 Apr 2016

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Steven E. Nissen, M.D., of the Cleveland Clinic, and colleagues identified patients with muscle-related adverse effects from statins and compared lipid-lowering efficacy for two nonstatin therapies, ezetimibe and evolocumab. The study was published online by JAMA, and is being released to coincide with its presentation at the American College of Cardiology's 65th Annual Scientific Session & Expo.

4 Apr 2016

Liu Laboratory at Augusta University studies exosomes using Particle Metrix’s ZetaView

Particle Metrix, developers of versatile particle characterization solutions for the life sciences, report on the work in the Liu Laboratory at Augusta University which is studying exosomes where size and concentration are critical parameters.

4 Apr 2016

Investigational drug abaloparatide-SC may help increase bone mineral density in postmenopausal women

The investigational drug abaloparatide-SC (subcutaneous) may help increase bone mineral density in postmenopausal women and reduce their risk of fracture, new industry-sponsored research suggests. The results of the subgroup analysis within the ACTIVE clinical trial will be presented Friday, April 1, at ENDO 2016, the annual meeting of the Endocrine Society in Boston.

4 Apr 2016

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

A safe, new, minimally invasive treatment, developed by interventional radiologists, led to sustained weight loss in severely obese people, according to research presented at the Society of Interventional Radiology's 2016 Annual Scientific Meeting. Researchers said the treatment--bariatric arterial embolization (BAE)--could offer individuals a viable, safe alternative to surgical weight-loss treatments.

4 Apr 2016

Janssen announces CHMP positive opinion for use of paliperidone palmitate 3-monthly injection for schizophrenia treatment

Janssen UK announced today that the Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the use of paliperidone palmitate 3-monthly injection for the maintenance treatment of schizophrenia in the European Union.

4 Apr 2016

CHMP recommends conditional marketing authorisation for Janssen’s daratumumab

Janssen-Cilag announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended the granting of a conditional marketing authorisation for first-in-class CD38 immunotherapy daratumumab in the European Union.

4 Apr 2016

Efficacy News and Research

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

Researchers identify severe side effects of Clozapine drug

Shortened RT schedule has similar efficacy as conventional RT schedule in low-risk prostate cancer patients

Ludwig, CRI launch Phase 1/2 trial of combination immunotherapy for advanced ovarian cancer

Clinical pharmacists in health care teams may improve quality, safety of patient care

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Immune-boosting formulation in Chinese herbal remedies comes from bacteria growing on Angelica roots

New technologies can improve memory, learning in cognitive deficit patients

New neurological mechanism can contribute to pain reduction

Losmapimod drug fails to meet primary endpoint in clinical trial

Scientists successfully turn off misbehaving protein that fuels growth of triple-negative breast cancer

Magnesium could be safe, cost-effective therapeutic intervention for genetic coagulation disorder

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Combining aromatase inhibitors with growth hormone may help short adolescent boys grow taller

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Liu Laboratory at Augusta University studies exosomes using Particle Metrix’s ZetaView

Investigational drug abaloparatide-SC may help increase bone mineral density in postmenopausal women

Bariatric arterial embolization could offer viable, safe alternative to surgical weight-loss treatments

Janssen announces CHMP positive opinion for use of paliperidone palmitate 3-monthly injection for schizophrenia treatment

CHMP recommends conditional marketing authorisation for Janssen’s daratumumab

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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