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Understanding the biomarkers and mechanisms associated with anti-NMDAR encephalitis

Encephalitis is a potentially life-threatening condition that involves inflammation of the brain. While some cases of encephalitis are caused by a bacterial or viral infection, other cases of 'autoimmune' encephalitis result when the body's own immune system attacks the brain.

8 Aug 2025

High-dose vitamin D strengthens bones in very low birth weight infants

Research indicates that high-dose vitamin D improves bone health in very low birth weight preterm infants, highlighting its role in early development.

8 Aug 2025

New insights into how SETD2 shapes immunity and disease

The emerging role of SETD2 in regulating immune cell function is shedding light on potential therapeutic strategies for a range of immune-related diseases.

7 Aug 2025

New antibody delivery system boosts Alzheimer's treatment in mice

A newly engineered antibody transport vehicle targeting the transferrin receptor enables enhanced delivery of anti-amyloid antibodies to the brains of mouse models of Alzheimer's disease, researchers report.

7 Aug 2025

Egg yolk compound shows promise in osteoporosis management

As osteoporosis becomes an increasingly common health concern worldwide, researchers are exploring alternative treatments to combat bone loss, which often leads to fractures.

7 Aug 2025

Updated multidisciplinary European guidelines redefine MASLD diagnosis and treatment

The 2024 European clinical practice guidelines introduce a pivotal terminology shift, replacing NAFLD (non-alcoholic fatty liver disease) with MASLD (metabolic dysfunction-associated steatotic liver disease) and NASH with MASH (metabolic dysfunction-associated steatohepatitis).

7 Aug 2025

Immune aging drives the progression of type 2 diabetes

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell failure.

6 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

Targeting lactate metabolism offers new avenues for cancer treatment

Lactic acid (LA) has transitioned from being perceived as a mere glycolytic waste product to a pivotal regulator of tumor-immune crosstalk.

5 Aug 2025

Starfish compound overcomes drug resistance in prostate cancer models

Researchers identified that triterpene glycosides from the starfish Solaster pacificus can kill drug-resistant prostate cancer cells in vitro by bypassing common resistance pathways. CuC1 showed synergy with existing chemotherapies, though with only moderate selectivity for cancer cells.

5 Aug 2025

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

5 Aug 2025

HIV trial points to semaglutide as a new anti-aging contender

Once-weekly semaglutide significantly slowed epigenetic aging in adults with HIV-associated lipohypertrophy, as measured by multiple DNA methylation clocks in a randomized controlled trial. These exploratory findings suggest GLP-1 receptor agonists could impact biological aging but require further validation in broader populations.

4 Aug 2025

Psychedelic and non-hallucinogenic drugs promote neuroplasticity through shared pathways

Understanding exactly how psychedelics promote new connections in the brain is critical to developing targeted, non-hallucinogenic therapeutics that can treat neurodegenerative and neuropsychiatric diseases.

4 Aug 2025

Metformin’s blood sugar control starts in the brain, not just the liver, study finds

Low, clinically relevant doses of metformin lower blood glucose by inhibiting the Rap1 protein in specific neurons of the hypothalamus, revealing a brain-first mechanism. This action is essential for metformin’s effect at therapeutic doses and highlights new directions for diabetes treatment.

3 Aug 2025

Mapping the brain’s serotonin switch could lead to better antidepressants

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.

1 Aug 2025

AI-designed protein activates Notch signaling pathway to boost T-cell production

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

1 Aug 2025

Two-drug combo shows durable benefit in advanced kidney cancer

A two-drug combination for treating advanced kidney cancer had sustained and durable clinical benefit in more than five years of follow-up, according to a study published Aug. 1 in Nature Medicine.

1 Aug 2025

Immunocompromised people are susceptible to skin cancer caused directly by beta-HPV

Researchers at the National Institutes of Health (NIH) have shown for the first time that a type of human papillomavirus (HPV) commonly found on the skin can directly cause a form of skin cancer called cutaneous squamous cell carcinoma (cSCC) when certain immune cells malfunction.

30 Jul 2025

Thalamic feedback pathway found to tune sensory perception

The cerebral cortex processes sensory information via a complex network of neural connections. How are these signals modulated to refine perception? A team from the University of Geneva (UNIGE) has identified a mechanism by which certain thalamic projections target neurons and modify their excitability.

30 Jul 2025

New strategy reveals how mannose receptor helps regulate blood proteins

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant glycoproteins accounting for 90 percent of the total mass.

30 Jul 2025

Receptor News and Research

Understanding the biomarkers and mechanisms associated with anti-NMDAR encephalitis

High-dose vitamin D strengthens bones in very low birth weight infants

New insights into how SETD2 shapes immunity and disease

New antibody delivery system boosts Alzheimer's treatment in mice

Egg yolk compound shows promise in osteoporosis management

Updated multidisciplinary European guidelines redefine MASLD diagnosis and treatment

Immune aging drives the progression of type 2 diabetes

HOXB13 emerges as a context-dependent regulator in cancer biology

Targeting lactate metabolism offers new avenues for cancer treatment

Starfish compound overcomes drug resistance in prostate cancer models

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

HIV trial points to semaglutide as a new anti-aging contender

Psychedelic and non-hallucinogenic drugs promote neuroplasticity through shared pathways

Metformin’s blood sugar control starts in the brain, not just the liver, study finds

Mapping the brain’s serotonin switch could lead to better antidepressants

AI-designed protein activates Notch signaling pathway to boost T-cell production

Two-drug combo shows durable benefit in advanced kidney cancer

Immunocompromised people are susceptible to skin cancer caused directly by beta-HPV

Thalamic feedback pathway found to tune sensory perception

New strategy reveals how mannose receptor helps regulate blood proteins

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