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Gene editing can trigger inflammatory, senescence-like responses in blood stem cells

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.

5 Jun 2025

Household environments may affect the likelihood of children developing eczema

Household environments, including owning a dog, may affect the likelihood of children developing eczema, according to an analysis of almost 300,000 people from across Europe.

4 Jun 2025

Emerging bat viruses closely related to MERS show potential to jump to humans

A group of bat viruses closely related to the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) could be one small mutation away from being capable of spilling over into human populations and potentially causing the next pandemic.

4 Jun 2025

Early contact with pet dogs protects genetically susceptible children from eczema

Having a dog at home could help to prevent eczema in children who are genetically prone to the condition, a study suggests.

4 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Early camizestrant therapy keeps advanced breast cancer in check

Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced breast cancer. The proactive, biomarker-guided approach allows earlier intervention and may redefine standard care.

3 Jun 2025

How does norepinephrine influence anxiety-related behaviours?

Discover how microscopy revealed the influence norepinephrine has on anxiety.

From Bruker Nano Surfaces and Metrology 3 Jun 2025

THP regimen achieves high response rates in HER2 positive breast cancer patients

Patients with Stage II and III (early-stage) HER2+ breast cancer usually undergo pre-operative therapy with multi-agent chemotherapy in combination with anti-HER2 antibodies, followed by surgery.

2 Jun 2025

Researchers show cannabis dependence drives links to psychiatric disorders

Research uncovers genetic connections between cannabis addiction and psychiatric disorders, urging a reevaluation of cannabis legalization and treatment.

2 Jun 2025

Immunotherapy before surgery boosts long term survival in lung cancer, trial shows

Results from a phase 3 clinical trial published in the New England Journal of Medicine, today (June 2nd) show that patients with lung cancer who received an immunotherapy drug, nivolumab, along with standard chemotherapy before surgery had improved long term survival compared to those who received chemotherapy alone, at 5 years after completing treatment.

2 Jun 2025

Engineered viruses and gene therapy halt tumor growth and extend survival in mice

This study reveals the potential of engineered phage-IL-12 therapy in melanoma, enhancing immune response and tumor destruction in aggressive cancer models.

2 Jun 2025

Terbium therapy shows promise in fighting lymphoma

Radionuclide therapy with the radioactive element terbium could effectively combat lymphoma. This is demonstrated by promising results from experiments carried out at the Paul Scherrer Institute PSI in collaboration with Inselspital - Bern University Hospital.

2 Jun 2025

Researchers identify gene driving aggressive prostate cancer

Researchers at the University of Michigan Rogel Cancer Center identified a gene that plays a key role in prostate cancer cells that have transitioned to a more aggressive, treatment-resistant form.

2 Jun 2025

New combination treatment offers hope for immune checkpoint blockade resistant skin cancers

A study has revealed why some patients don't respond to immune checkpoint blockade (ICB) therapy for solid cancer tumors and identifies a new combination treatment.

2 Jun 2025

Treatment switching guided by liquid biopsy results improves outcomes in advanced breast cancer

A large prospective, randomized clinical trial in patients with advanced breast cancer has found that the use of liquid biopsy blood tests for early detection of a treatment-resistance mutation, followed by a switch to a new type of treatment, substantially extends the period of tumor control compared to standard care.

1 Jun 2025

Dual-target CAR T cell therapy shrinks tumors in aggressive brain cancer

A dual-target CAR T cell therapy approach shows promise for slowing tumor growth in a notoriously aggressive and fast-growing brain cancer.

1 Jun 2025

Combination treatment extends progression-free survival in advanced skin cancer

In patients with an advanced type of skin cancer called cutaneous squamous cell carcinoma (cSCC), those who received the combination of the immunotherapy drug avelumab and targeted agent cetuximab had almost four times longer median progression-free survival compared to patients who received avelumab alone, according to the results of a phase 2 trial presented today at the American Society of Clinical Oncology (ASCO) meeting and concurrently published in the Journal of Clinical Oncology.

1 Jun 2025

Leading health organizations release guidance on nutrition support for GLP-1 obesity therapies

Four leading organizations in lifestyle medicine, obesity medicine, and nutrition-the American College of Lifestyle Medicine (ACLM), the American Society for Nutrition (ASN), the Obesity Medicine Association (OMA), and The Obesity Society (TOS)-have jointly released a clinical advisory titled "Nutritional Priorities to Support GLP-1 Therapy for Obesity."

31 May 2025

Universal CAR T cell therapy shows promise for aggressive T cell cancers

A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis.

31 May 2025

Mass General Brigham researchers share cancer research discoveries at ASCO 2025

Researchers from Mass General Brigham will present research discoveries and outcomes from clinical trials in cancer at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, held May 30-June 3, in Chicago.

30 May 2025

Receptor News and Research

Gene editing can trigger inflammatory, senescence-like responses in blood stem cells

Household environments may affect the likelihood of children developing eczema

Emerging bat viruses closely related to MERS show potential to jump to humans

Early contact with pet dogs protects genetically susceptible children from eczema

Navigating the dual role of B cells in tumor immunity

Early camizestrant therapy keeps advanced breast cancer in check

How does norepinephrine influence anxiety-related behaviours?

THP regimen achieves high response rates in HER2 positive breast cancer patients

Researchers show cannabis dependence drives links to psychiatric disorders

Immunotherapy before surgery boosts long term survival in lung cancer, trial shows

Engineered viruses and gene therapy halt tumor growth and extend survival in mice

Terbium therapy shows promise in fighting lymphoma

Researchers identify gene driving aggressive prostate cancer

New combination treatment offers hope for immune checkpoint blockade resistant skin cancers

Treatment switching guided by liquid biopsy results improves outcomes in advanced breast cancer

Dual-target CAR T cell therapy shrinks tumors in aggressive brain cancer

Combination treatment extends progression-free survival in advanced skin cancer

Leading health organizations release guidance on nutrition support for GLP-1 obesity therapies

Universal CAR T cell therapy shows promise for aggressive T cell cancers

Mass General Brigham researchers share cancer research discoveries at ASCO 2025

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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