Statin News and Research

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Statins are drugs used to lower cholesterol. Your body needs some cholesterol to work properly. But if you have too much in your blood, it can stick to the walls of your arteries, narrowing or even blocking them.

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Tricor disappoints in diabetes trial

Researchers say the results of a large trial of a drug to lower triglycerides failed in its primary goal of significantly reducing heart attacks and coronary deaths among patients with type II diabetes.

15 Nov 2005

Role of statin therapy in patients with heart failure

An advanced study launched at Yale School of Medicine is evaluating the role of statin therapy in patients with heart failure, one of the leading causes of hospitalization in people over age 65.

14 Nov 2005

Statins reduce the risk of stroke after carotid artery endarterectomy

Carotid artery endarterectomy (CEA) is the most commonly performed operation to prevent stroke in the United States. However, the operation itself carries a small risk of stroke.

13 Nov 2005

Scientists identify molecular link between body fat and blood lipids

Scientists from Wageningen University in the Netherlands have discovered that a factor released from body fat, which they call Fasting-Induced Adipose Factor or FIAF, has a major impact on blood levels of HDL and triglycerides in mice.

10 Nov 2005

Statin drug reverses learning and attention deficits in a mouse model of the genetic disorder Neurofibromatosis type I

This week, researchers report evidence that a statin drug already shown to be safe for use in humans has proven effective at correcting cell-cell communication and curing learning disfunction in a mouse model of Neurofibromatosis type I, a human genetic disorder that causes learning disabilities in millions of people worldwide.

7 Nov 2005

Cholesterol lowering drugs do not appear to decrease the risk of melanoma

No clear evidence exists that some widely-prescribed cholesterol-lowering drugs can decrease the risk of melanoma, a deadly and malignant skin cancer, according to a new review of recent studies.

7 Nov 2005

Pravastatin is highly effective in lowering the risk of heart attack

The cholesterol-lowering drug pravastatin is highly effective in lowering the risk of heart attack and other cardiovascular events in patients with diabetes and chronic kidney disease (CKD), reports a study in the December Journal of the American Society of Nephrology.

27 Oct 2005

Cholesterol levels and use of statins are not associated with breast cancer risk

Although some evidence suggests that statins (the most commonly used type of lipid-lowering drugs) may inhibit tumor development and may work in combination with chemotherapy drugs against cancer, studies on the association between the use of statins and breast cancer have had conflicting results

25 Oct 2005

New glaucoma risk calculator

High eye pressure is the leading risk factor for glaucoma, and is the only modifiable one. If glaucoma is untreated, vision loss may continue, leading to blindness in some individuals.

17 Oct 2005

Very low LDL cholesterol levels appear to be safe for heart patients on statin therapies

"There was no apparent safety concern for patients whose resultant LDL on intensive therapy was lower than current guidelines. There was a trend toward improved clinical outcomes in the lowest LDL groups," said Stephen D. Wiviott, M.D., from Brigham and Women's Hospital in Boston, Massachusetts.

11 Oct 2005

Cholesterol levels among older adults has declined significantly

The total cholesterol level among older adults has declined significantly, while there has been little change among younger adults, according to a study in the October 12 issue of JAMA: The Journal of the American Medical Association.

11 Oct 2005

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

A study published in The Lancet shows that Takeda's Actos (pioglitazone HCl), an oral glucose lowering medication, significantly reduces the combined risk of non-fatal heart attacks, strokes and deaths by an additional 16% on top of standard medication

10 Oct 2005

Quality-improvement improves mortality in hospital

Heart attack death rates dropped significantly at hospitals that participated in a quality-improvement process that increased the use of evidence-based therapies, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Benefits of statin therapy identified

The greater the reduction in LDL (lower-density lipoprotein) cholesterol achieved by statin therapy the greater the reduction in incidence of major coronary events, coronary revascularisation and stroke, concludes a meta-analysis published online today by The Lancet.

27 Sep 2005

$Statin use associated with a 36 percent reduction in risk of fracture$

Statin use associated with a 36 percent reduction in risk of fracture

In a large study of elderly, predominately male veterans, statin use was associated with a 36 percent reduction in risk of fracture when compared with no lipid-lowering therapy, according to a study in the Archives of Internal Medicine

26 Sep 2005

HDL cholesterol helps prevent blocked arteries and heart attack

Cardiology experts at Johns Hopkins have issued interim guidelines for physicians on how best to treat low levels of HDL cholesterol, the so-called good cholesterol, which helps keep arteries clear from the buildup of LDL cholesterol, the so-called bad cholesterol.

22 Sep 2005

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke.

19 Sep 2005

Sports and exercise - in addition to preventing obesity and diabetes - directly improve vascular function and reduce atherosclerosis

When asked about his personal recipe for old age, Winston Churchill used to answer: "First of all: No sports." While being a visionary figure in world politics researchers in cardiovascular exercise science today would unanimously reply to his medical hypothesis: "Sorry, you are wrong."

5 Sep 2005

Nurse-led multidisciplinary programme can help coronary patients and their families to reduce their risk of major cardiovascular disease

Early results from the EuroAction hospital project, announced today at the European Society of Cardiology, demonstrate how a nurse-led multidisciplinary programme, organised in busy general hospitals, can help coronary patients and their families to reduce their risk of major cardiovascular disease (CVD).