Protein C News and Research

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Study suggests a novel therapeutic target to reverse lung fibrosis

Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.

24 Aug 2021

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

By applying a systems biology approach, a recent bioRxiv* preprint research paper by scientists from the Icahn School of Medicine at Mount Sinai in New York unveils interactions between the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and p38 mitogen-activated protein kinase (MAPK) pathway responsible for regulating the expression of crucial inflammatory mediators in human lung epithelial cells.

23 Aug 2021

Study suggests algorithm may help optimize future COVID-19 vaccine design

Scientists predict the COVID-19 pandemic is on its way to becoming endemic. The rising spread of COVID-19 variants such as Delta has helped infect unvaccinated and some vaccinated individuals. COVID-19 vaccines continue to be the best way to protect against severe illness and death, but there may be a need for vaccines to protect against a specific variant.

23 Aug 2021

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Researchers at Children's National Hospital identified a vulnerability in a developmental signaling pathway that can be hijacked to drive pediatric low-grade glioma (pLGG) formation, according to a pre-clinical study published in Developmental Cell.

23 Aug 2021

Study identifies a novel potential biomarker for hepatocellular carcinoma

Aging-US published "Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma" which reported that there is still a lack of comprehensive analysis of the circular RNA -long non-coding RNA -miRNA-mRNA ceRNA network in hepatocellular carcinoma.

23 Aug 2021

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Sjögren's syndrome is an autoimmune disease that attacks the tear system in the eyes and salivary glands, leading to patients experiencing extremely dry eyes and mouth.

23 Aug 2021

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

The potency of neutralizing antibodies in individuals who have recovered from SARS-CoV and received the SARS-CoV-2 vaccine is evaluated.

23 Aug 2021

New mathematical model can predict the optimum exercise regime for building muscle

Researchers have developed a mathematical model that can predict the optimum exercise regime for building muscle.

23 Aug 2021

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death.

23 Aug 2021

FDA-approved antiplatelet drug shows potential as new, low-cost heart failure therapy

Sarpogrelate, an antiplatelet medication, has potential as a new heart failure therapy and, according to researchers, could potentially decrease health care costs associated with cardiovascular disease, according to preliminary animal research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2021.

23 Aug 2021

FDA approves COVID-19 mRNA vaccine that uses fundamental Penn technology

The U.S. Food and Drug Administration has given the first full approval to a COVID-19 mRNA vaccine, which uses modified mRNA technology invented and developed by scientists in the Perelman School of Medicine at the University of Pennsylvania, whose years of research in mRNA science laid a critical piece of the foundation for the largest global vaccination campaign in history.

23 Aug 2021

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

A new study determined the antibody response to SARS-CoV-2 and seasonal viruses induced by BNT162b2-Comirnaty vaccination in healthcare workers.

23 Aug 2021

Does SARS-CoV-2 affect male fertility?

A recently published review describes the state of current knowledge regarding the impact of SARS-CoV-2 on the male reproductive system.

23 Aug 2021

The emergence and spread of the SARS-CoV-2 Lambda (B.1.621) variant

A new study details the genomic characteristics and descent of a SARS-CoV-2 variant of interest.

23 Aug 2021

New study identifies novel compound as promising pan-coronavirus drug candidate

A recent study describes a novel compound with frameshifting capability against MERS-CoV, inhibiting viral propagation within infected cells.

23 Aug 2021

Researchers identify eight primary factors that increase GI bleeding risk after heart attack

Researchers at Karolinska Institutet in Sweden have identified eight primary factors that increase the risk of a common bleeding complication after heart attack. Some of these factors are already known, but using machine learning techniques, the researchers have found additional predictors, such as smoking, blood pressure and blood glucose.

23 Aug 2021

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

A new study published on the bioRxiv* preprint server focused on the development of dynamic computational models for a large subset of S proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2.

23 Aug 2021

Drinking alcohol at a young age associated with accelerated arterial stiffening

Drinking alcohol during adolescence to young adulthood is associated with accelerated arterial stiffening, a precursor to cardiovascular disease. That's the finding of a study presented at ESC Congress 2021.

23 Aug 2021

Study investigates the effects of calycosin on breast cancer cell progression

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression.

23 Aug 2021

Study offers hope for an era of safer chemotherapy in breast cancer

Breast cancer is the deadliest and most common type of cancer in women. The treatment options often require administration of anti-cancer drugs in high doses, as the cells develop resistance towards chemotherapy, leading to painful side effects in patients.

23 Aug 2021

Protein C News and Research

Study suggests a novel therapeutic target to reverse lung fibrosis

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

Study suggests algorithm may help optimize future COVID-19 vaccine design

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Study identifies a novel potential biomarker for hepatocellular carcinoma

New mouse model may help elucidate the pathogenic mechanisms behind Sjögren's syndrome

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

New mathematical model can predict the optimum exercise regime for building muscle

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

FDA-approved antiplatelet drug shows potential as new, low-cost heart failure therapy

FDA approves COVID-19 mRNA vaccine that uses fundamental Penn technology

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

Does SARS-CoV-2 affect male fertility?

The emergence and spread of the SARS-CoV-2 Lambda (B.1.621) variant

New study identifies novel compound as promising pan-coronavirus drug candidate

Researchers identify eight primary factors that increase GI bleeding risk after heart attack

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

Drinking alcohol at a young age associated with accelerated arterial stiffening

Study investigates the effects of calycosin on breast cancer cell progression

Study offers hope for an era of safer chemotherapy in breast cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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