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New insights on events that lead to immortalized cells

Researchers at Umeå University can now show that cells that grow forever get this capacity through gradual changes in the expression of genes that govern the repair of DNA damage and regulate growth and cell death. The research also shows that activation of the enzyme complex telomerase, which is necessary for unlimited growth, occurs late in this process.

29 Mar 2010

Scientists identify gene that pushes hybrid tomato plants to increase yield

Giving tomato breeders and ketchup fans something to cheer about, a Cold Spring Harbor Laboratory scientist and his colleagues at the Hebrew University in Israel have identified a gene that pushes hybrid tomato plants to spectacularly increase yield.

29 Mar 2010

Pathway Genomics Genetic Health Report helps make more informed health and lifestyle decisions

You may not suffer from any form of heart disease, high blood pressure, or high cholesterol, but you could have a predisposition for these conditions based on more than just your lifestyle or diet. A family history of diabetes, gout, high blood pressure or high blood cholesterol can increase one’s risk regardless of lifestyle.

27 Mar 2010

Antiviral treatment may lead to drug-resistant H1N1 virus: NIAID

Two people with compromised immune systems who became ill with 2009 H1N1 influenza developed drug-resistant strains of virus after less than two weeks on therapy, report doctors from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

27 Mar 2010

Presence of PARP protein in tumours can help predict their response to chemotherapy

The presence of the protein poly polymerase in tumours can help predict their response to chemotherapy, a German scientist will tell the seventh European Breast Cancer Conference in Barcelona tomorrow (Saturday 27 March).

27 Mar 2010

Studies shed light on treatment options for women carrying BRCA1 and BRCA2 genetic mutations

Two studies to be presented at the seventh European Breast Cancer Conference (EBCC7) in Barcelona today (Friday) and tomorrow (Saturday), shed light on the treatment options facing women carrying the BRCA1 and BRCA2 genetic mutations which predispose them to breast cancer.

27 Mar 2010

Genome sequencing of tumors biopsied from women with invasive breast cancer

Tumors biopsied from women with invasive breast cancer are having their genomes sequenced in an attempt to develop a DNA profile that one day may identify ahead of time the patients who will most likely respond to chemotherapy with an aromatase inhibitor. Aromatase inhibitors are a class of chemotherapeutic agents that block the production of estrogen in postmenopausal women.

27 Mar 2010

Dian Donnai receives March of Dimes/Colonel Harland Sanders Award for achievement in genetic sciences

A pioneering professor and investigator at the forefront of genetic services in the United Kingdom and who helped define rare genetic diseases is the 2010 recipient of the March of Dimes/Colonel Harland Sanders Award for lifetime achievement in the field of genetic sciences.

27 Mar 2010

Genetic instability in people with Fanconi anemia: New proteins in FA DNA repair pathway may help explain

Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with Fanconi anemia and how otherwise healthy people are susceptible to cancer from environmentally triggered DNA damage.

26 Mar 2010

Study finds 15-year outcomes of BCT and mastectomy similar

26 Mar 2010

Presence of protein PARP in tumours may help predict response to chemotherapy

The presence of the protein poly (ADP-ribose) polymerase (PARP) in tumours can help predict their response to chemotherapy, a German scientist will tell the seventh European Breast Cancer Conference (EBCC7) in Barcelona tomorrow (Saturday 27 March). Professor Gunter von Minckwitz, from the German Breast Group Forschungs GmBH, Neu-Isenburg, says that, contrary to current belief that PARP is associated with a limited number of tumours, he and his team found for the first time that PARP expression exists across all breast cancer subtypes, and that such tumours were highly sensitive to chemotherapy.

26 Mar 2010

Muscular dystrophy: $1M grant for study of erectile dysfunction drugs in improving muscle blood flow

A Cedars-Sinai Heart Institute cardiologist has been awarded a three-year, nearly $1 million grant from the Muscular Dystrophy Association (MDA) to study whether drugs used to treat erectile dysfunction could also be used to improve muscle blood flow and reduce fatigue in muscular dystrophy patients.

26 Mar 2010

Data on Argos Therapeutics' Phase 2a AGS-004 immunotherapy trial presented at Banff HIV Vaccines meeting

Argos Therapeutics today announced the presentation of data from the Phase 2a trial of AGS-004, providing information on rebound viral genetic diversity in HIV patients treated with the personalized immunotherapy following antiretroviral therapy (ART) interruption. The data were discussed in a poster session at the Keystone Symposia Global Health Series HIV Vaccines meeting, held March 21-26, 2010 in Banff, Canada.

26 Mar 2010

Animal study shows chymase inhibitors could advance treatments for high BP and heart failure

Millions of patients with high blood pressure and heart failure take a class of drugs known as ACE (angiotensin-converting enzyme) inhibitors. These drugs prevent the body from processing angiotensin II, a hormone that constricts blood vessels.

26 Mar 2010

Genetic variation associated with lower risk of sudden cardiac arrest:Study

Physician-scientists at the Cedars-Sinai Heart Institute have found that a genetic variation is associated with lower risk of sudden cardiac arrest, a disorder that gives little warning and is fatal in about 95 percent of cases. Findings will be published tomorrow by the Public Library of Science (PloS One).

25 Mar 2010

Novel test may help identify newborns with fragile X syndrome

A newly developed test appears highly accurate in identifying newborns with fragile X syndrome—the most common inherited cause of cognitive impairment—as well as identifying couples who are carriers of the causative gene, reports a study in the March issue of Genetics in Medicine, the official peer-reviewed journal of The American College of Medical Genetics.

25 Mar 2010

Committee recommends inclusion of genetic diseases in newborn screening program

The experts who make recommendations for genetic disease screening in newborns face a challenging task: To make conclusions based on the most authoritative available evidence, while considering gaps in the research on such rare conditions, as well as their human impact. An overview of the steps followed by the expert panels tasked with making these recommendations is presented in a special section of the current issue of Genetics in Medicine, the official peer-reviewed journal of The American College of Medical Genetics.

25 Mar 2010

Cardiologist receives grant to study impact of erectile dysfunction drugs on muscular dystrophy patients

25 Mar 2010

Anesthesia can increase behavioral changes, risk of developing Alzheimer's disease

The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria -ngeles Mena and Justo Garc-a de Y-benes, from CIBERNED (Centro de Investigaci-n Biom-dica en Red de Enfermedades Neurodegenerativas).

25 Mar 2010

Protein deficiency in Down syndrome patients could contribute to cognitive impairment and congenital heart defects

Conventional wisdom among scientists for years has suggested that because individuals with Down syndrome have an extra chromosome, the disorder most likely results from the presence of too many genes or proteins contained in that additional structure.

24 Mar 2010

Mutation News and Research

New insights on events that lead to immortalized cells

Scientists identify gene that pushes hybrid tomato plants to increase yield

Pathway Genomics Genetic Health Report helps make more informed health and lifestyle decisions

Antiviral treatment may lead to drug-resistant H1N1 virus: NIAID

Presence of PARP protein in tumours can help predict their response to chemotherapy

Studies shed light on treatment options for women carrying BRCA1 and BRCA2 genetic mutations

Genome sequencing of tumors biopsied from women with invasive breast cancer

Dian Donnai receives March of Dimes/Colonel Harland Sanders Award for achievement in genetic sciences

Genetic instability in people with Fanconi anemia: New proteins in FA DNA repair pathway may help explain

Study finds 15-year outcomes of BCT and mastectomy similar

Presence of protein PARP in tumours may help predict response to chemotherapy

Muscular dystrophy: $1M grant for study of erectile dysfunction drugs in improving muscle blood flow

Data on Argos Therapeutics' Phase 2a AGS-004 immunotherapy trial presented at Banff HIV Vaccines meeting

Animal study shows chymase inhibitors could advance treatments for high BP and heart failure

Genetic variation associated with lower risk of sudden cardiac arrest:Study

Novel test may help identify newborns with fragile X syndrome

Committee recommends inclusion of genetic diseases in newborn screening program

Cardiologist receives grant to study impact of erectile dysfunction drugs on muscular dystrophy patients

Anesthesia can increase behavioral changes, risk of developing Alzheimer's disease

Protein deficiency in Down syndrome patients could contribute to cognitive impairment and congenital heart defects

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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