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Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Existing drugs block or reduce SARS-CoV2 infection in cells

Since the beginning of the pandemic, researchers worldwide have been looking for ways to treat COVID-19. And while the COVID-19 vaccines represent the best measure to prevent the disease, therapies for those who do get infected remain in short supply.

19 Aug 2021

Rare gene variant increases zoonotic H7N9 virus susceptibility in humans

Rare, single-nucleotide variants in the MX1 gene increase human susceptibility to zoonotic H7N9 avian influenza infection, according to a new study.

19 Aug 2021

Researchers identify antibodies that could protect against alphaviruses

Alphaviruses - mosquito-borne viruses that can trigger brain infections and arthritis - may have met their match.

19 Aug 2021

Urine test for detecting chronic kidney disease is not used enough in high-risk groups, study suggests

Despite their higher risk of chronic kidney disease, people with hypertension or diabetes usually are not given a simple test for protein in the urine to screen for this potentially deadly disorder, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

19 Aug 2021

Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

In a small study published in the medRxiv* preprint server, people given a booster Johnson & Johnson COVID-19 shot showed elevated and robust antibody levels.

19 Aug 2021

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

A fascinating and timely new study shows how the Delta variant of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) achieved higher transmissibility and resistance to neutralization.

19 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

People with cognitively stimulating jobs have lower risk of dementia in old age, study finds

People with mentally stimulating jobs have a lower risk of dementia in old age than those with non-stimulating jobs, finds a study published by The BMJ today.

19 Aug 2021

Early clinical trial data in for whole virus COVID-19 vaccine candidate

In a study uploaded to the preprint server medRxiv*, the efficacy of a whole virion Coronavirus vaccine was determined by giving the vaccine to healthy adult volunteers, which generated a robust immune response with evidence of T-cell activation.

19 Aug 2021

Arteriolar niche used by breast cancer cells to prepare for metastasis

More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps.

19 Aug 2021

White-tailed deer are highly susceptible to SARS-CoV-2 infection

The SARS-CoV-2 virus has been shown to infect a wide range of animals naturally and experimentally, and prior studies indicate deer are susceptible to infection. White-tailed deer (Odocoileus virginianus) fawns have been found to be susceptible to SARS-CoV-2.

19 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

A scientific achievement for researchers at Tel Aviv University: printing an entire active and viable glioblastoma tumor using a 3D printer.

18 Aug 2021

Genomic surveillance is vital to combat COVID-19

Although the development and increasingly widespread availability of effective and safe vaccines provides the greatest hope for the future recovery from the increasingly devastating COVID-19 pandemic, genomic surveillance is emerging as a vital necessity to achieve effective mitigation and containment.

18 Aug 2021

The White House says boosters for all. Here’s what you need to know.

The Biden administration announced plans Wednesday to offer boosters to all U.S. adults as soon as next month, saying that recent data, including some made available only in the past few days, played a role in that decision.

18 Aug 2021

How do glycans affect SARS-CoV-2 spike protein openings?

In a paper recently uploaded to the bioRxiv* preprint server, the role of glycan coating on the SARS-CoV-2 spike protein is further investigated by molecular dynamics simulations of the glycosylated and non-glycosylated protein, identifying several key glycans that play a role in stabilizing and protecting the RBD, and also encourage bonding with the ACE2 receptor.

18 Aug 2021

Study examines the prevalence of SARS-CoV-2 antibodies in Geneva, Switzerland

In a paper uploaded to the preprint server medRxiv*, antibodies against both the spike protein and nucleocapsid proteins of SARS-CoV-2 are measured in over 3,000 volunteers, six months following the initiation of the vaccination scheme in Geneva, Switzerland.

18 Aug 2021

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn Medicine published online in Molecular Cell.

18 Aug 2021

Rush to boosters sparks confusion, differing recommendations

When the Food and Drug Administration announced last week that a third dose of Moderna or Pfizer-BioNTech covid-19 vaccine may boost the immunity of some people who are immunocompromised, officials repeated their stance that fully vaccinated, healthy people do not need another dose.

18 Aug 2021

Protein C News and Research

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

Existing drugs block or reduce SARS-CoV2 infection in cells

Rare gene variant increases zoonotic H7N9 virus susceptibility in humans

Researchers identify antibodies that could protect against alphaviruses

Urine test for detecting chronic kidney disease is not used enough in high-risk groups, study suggests

Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

People with cognitively stimulating jobs have lower risk of dementia in old age, study finds

Early clinical trial data in for whole virus COVID-19 vaccine candidate

Arteriolar niche used by breast cancer cells to prepare for metastasis

White-tailed deer are highly susceptible to SARS-CoV-2 infection

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

Genomic surveillance is vital to combat COVID-19

The White House says boosters for all. Here’s what you need to know.

How do glycans affect SARS-CoV-2 spike protein openings?

Study examines the prevalence of SARS-CoV-2 antibodies in Geneva, Switzerland

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

Rush to boosters sparks confusion, differing recommendations

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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