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Indian physicians concerned about malaria drug resistance, recommend combination therapy

India has reported an increase in drug-resistant malaria cases this year, leading physicians to express concern and recommend that the disease be treated with a combination of drugs, India's Daily News and Analysis reports.

26 Aug 2008

Breakthrough discovery may lead to new drugs to fight bird flu, other epidemics

Researchers at Rutgers University and The University of Texas at Austin have reported a discovery that could help scientists develop drugs to fight the much-feared bird flu and other virulent strains of influenza.

25 Aug 2008

Gene responsible for rare and inherited, deadly childhood cancer discovered

The discovery of a gene which causes a rare, inherited and deadly form of childhood cancer, could lead to new treatments for the disease.

25 Aug 2008

Bath researchers study how cancer cells come unstuck

Scientists in the Department of Biology & Biochemistry at the University of Bath have started a three year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.

21 Aug 2008

Bone marrow stem cells used to protect gastrointestinal tissue from autoimmune attack

Massachusetts General Hospital (MGH) investigators have found that infusions of a particular bone marrow stem cell appeared to protect gastrointestinal tissue from autoimmune attack in a mouse model.

20 Aug 2008

Scientists discover how mutation in the copper-regulating protein ATP7B causes Wilson disease

Using a combination of computer simulations and cutting-edge lab experiments, physical biochemists at Rice University have discovered how a small genetic mutation -- which is known to cause Wilson disease -- subtly changes the structure of a large, complex protein that the body uses to keep copper from building up to toxic levels.

19 Aug 2008

Rifamycin antibiotics attack tuberculosis bacteria with walls, not signals

Amid concerns about the rising number of new tuberculosis cases worldwide, researchers led by Rockefeller University's Seth A. Darst have reexamined and disproved a theory that describes how a potent class of antibiotics kills a deadly form of bacteria. The findings, which will appear in this week's online issue of the Proceedings of the National Academy of Sciences, not only bring scientists closer to understanding how these antibiotics work but also how the bacteria become resistant to their effects.

19 Aug 2008

Discovery of major genetic cause of colorectal cancer

About one-third of colorectal cancers are inherited, but the genetic cause of most of these cancers is unknown. The genes linked to colorectal cancer account for less than 5 percent of all cases.

14 Aug 2008

New model for studying the genetics of Angelman syndrome

A model for studying the genetics of Angelman syndrome, a neurological disorder that causes mental retardation and other symptoms in one out of 15,000 births, has been developed by biologists at The University of Texas at Austin.

14 Aug 2008

A snooze button for the circadian clock

We may use the snooze button to fine-tune our sleep cycles, but our cells have a far more meticulous and refined system. Humans, and most other organisms, have 24-hour rhythms that are regulated by a precise molecular clock that ticks inside every cell.

13 Aug 2008

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

AIDS experts at Johns Hopkins say they have compelling evidence that some people with HIV who for years and even decades show extremely low levels of the virus in their blood never progress to full-blown AIDS and remain symptom free even without treatment, probably do so because of the strength of their immune systems, not any defects in the strain of HIV that infected them in the first place.

12 Aug 2008

Medulloblastoma in children - two studies find clues to treatment

Medulloblastoma is one of the most common and most malignant brain tumours among children and teenagers. These tumours grow very rapidly, and fifty percent of patients in the long term die from the condition. The details of the processes that lead to the growth of these tumours have remained unknown until now.

12 Aug 2008

Australian researchers reveal how cancers become more aggressive

A team of Australian scientists have discovered how some cancers are able to mutate into more aggressive and potentially fatal cancers in the human body.

11 Aug 2008

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE).

11 Aug 2008

Finding cancer's original cell key to treatments

Cancer biologists are turning their attention to the normal cells that give rise to cancers, to learn more about how tumor growth might be stopped at the earliest opportunity.

11 Aug 2008

Cancer survival secrets discovered by Australian researchers

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body.

11 Aug 2008

Medulloblastoma originates in normal brain "stem" cells that turn malignant

An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

11 Aug 2008

Scientists discover reservoir of mitochondrial DNA mutations present in the general population

Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease.

11 Aug 2008

Designer RNA fights high cholesterol, medical researchers find

Small, specially designed bits of ribonucleic acid (RNA) can interfere with cholesterol metabolism, reducing harmful cholesterol by two-thirds in pre-clinical tests, according to a new study by researchers at UT Southwestern Medical Center in collaboration with Alnylam Pharmaceuticals and the Massachusetts Institute of Technology.

11 Aug 2008

Thirteen Indonesian villagers clear of bird flu

Health officials in Indonesia say 13 people from a village on Sumatra who were hospitalised with suspected bird flu, have all tested negative for the H5N1 virus.

11 Aug 2008