Signaling Pathway News and Research

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Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell.

13 Feb 2018

Study adds more evidence that intestinal microbiome plays substantial role in obesity

A new Johns Hopkins study of mice with the rodent equivalent of metabolic syndrome has added to evidence that the intestinal microbiome - a "garden" of bacterial, viral and fungal genes - plays a substantial role in the development of obesity and insulin resistance in mammals, including humans.

6 Feb 2018

UIC scientists identify new chemical compound to stop bacteria from causing sickness

A study published in the Journal of Biological Chemistry is the first to describe a signaling pathway that affects communication -- a process called quorum sensing -- between Streptococcus bacteria cells.

6 Feb 2018

$Researchers develop novel method to aid fracture recovery$

Researchers develop novel method to aid fracture recovery

Researchers from Michigan Medicine have developed a novel method to aid the repair of difficult-to-heal fractures.

2 Feb 2018

Scientists identify new approach to enhance bone healing

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly -- even with the aid of pins, plates or a cast.

1 Feb 2018

Research reveals why patients with diabetes have poorer prognosis for prostate cancer

Men with type 2 diabetes are less likely to develop prostate cancer than patients without diabetes. However, the mortality rate is higher.

31 Jan 2018

Metabolic shift can result in congestive heart failure

The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center and Heidelberg University Hospital have now discovered.

23 Jan 2018

Scientists take tissue-engineering approach to improve healing related to skeletal system

"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the most easily injured.

23 Jan 2018

Signaling molecules likely involved in concussions, rodent studies show

Traumatic brain injuries, whether suffered from a blow on the football field or the battle field, can be devastating, leading to disability and shortened lives.

18 Jan 2018

Researchers identify new anti-inflammatory drug target

A new study suggests that parmodulins may provide anti-inflammatory and anti-thrombotic protection to endothelial cells, without interfering with clotting.

16 Jan 2018

Genes involved in spinal cord repair of lamprey also present in mammals, study reveals

Many of the genes involved in natural repair of the injured spinal cord of the lamprey are also active in the repair of the peripheral nervous system in mammals, according to a study by a collaborative group of scientists at the Marine Biological Laboratory and other institutions.

16 Jan 2018

Lamprey genes provide clues to repair spinal cord damage, finds study

Researchers have found that several genes within an ancient species of fish can be used to provide clues in the treatment of spinal cord damage. The study titled, “Highly Conserved Molecular Pathways, Including Wnt Signaling, Promote Functional Recovery from Spinal Cord Injury in Lampreys,” appeared in the latest issue of the journal Scientific Reports.

15 Jan 2018

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

12 Jan 2018

UCLA scientists coax human stem cells to become sensory interneurons

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of touch.

11 Jan 2018

CHOP researchers explore effective nutritional therapies for mitochondrial disease

Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems.

10 Jan 2018

Research reveals how Zika virus infection spurs fetal demise

A powerful antiviral protein may act as a checkpoint for keeping or ending a pregnancy.

5 Jan 2018

Study reveals a loophole in treatment of chronic lymphocytic leukemia

A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients.

4 Jan 2018

Study suggests potential means of stalling or even reversing diabetes-related blindness

Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels in the retina, leading to blindness.

3 Jan 2018

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

FDA-approved drug to treat high blood pressure increases life span in worms

UT Southwestern Medical Center researchers find that an FDA-approved drug to treat high blood pressure seems to extend lifespan in worms via a cell signaling pathway that may mimic caloric restriction.

21 Dec 2017