UIC scientists identify new chemical compound to stop bacteria from causing sickness

A study published in the Journal of Biological Chemistry is the first to describe a signaling pathway that affects communication -- a process called quorum sensing -- between Streptococcus bacteria cells.

This type of bacterium is responsible for illnesses like strep throat, scarlet fever, and some cases of soft tissue infections and pneumonia. In extreme cases, or when bacteria become resistant to antibiotics, these common but serious infections can lead to death.

The University of Illinois at Chicago researchers who wrote the paper have been studying Streptococcus bacteria and have hypothesized that quorum sensing pathways are ideal drug targets for manipulating bacterial activity and suppressing virulence.

"Quorum sensing is how bacteria regulate their behavior as a collective," said Michael Federle, corresponding author on the study. "This social regulation may provide many benefits to bacteria and, in the case of bad bacteria, may help promote survival and help defend against the immune system."

That is why Federle and his team have developed a tool to help study the quorum sensing signaling pathways. Their technology allows them to easily monitor specific gene activities and whether chemicals or other conditions affect gene expression.

Using this technique, the UIC scientists have unlocked part of the communication process and identified a small molecule that promotes quorum sensing in Streptococci. This molecule stabilizes the chemical signal -- called a pheromone -- transmitted between cells. More specifically, the compound works by blocking the enzyme that would otherwise degrade the pheromone before it can deliver a message, thus promoting its ability to act as a signal.

"We identified a molecule that disrupts inhibition of signaling," said Federle, associate professor of medicinal chemistry and pharmacognosy in the UIC College of Pharmacy. "Now that we identified this pathway and this chemical compound, we can look further for ways to manipulate quorum sensing and even silence the communication between cells."

By silencing this communication, Federle says, it might be possible "to convince bacteria to remain in a non-hostile state," something he considers vital in the face of rising antibiotic resistance in society.

"We're losing the war with bacteria," he said. "Every antibiotic we've come up with has some level of resistance in nature. We need a way to stop bacteria before they become a threat and require treatment."

Federle says this is analogous to finding a diplomatic solution or mediating a conflict before it causes harm.

Source: https://today.uic.edu/new-compound-may-stop-bacteria-from-causing-sickness

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
UF Health scientists receive major grant to combat antibiotic-resistant bacteria