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Study raises questions about prostate cancer therapies targeting IGF-1

Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center.

1 May 2008

New insight into how the nervous system processes sensory information

The Stowers Institute's Yu Lab has published the results of large-scale imaging experiments examining how social signals are represented in the sensory system.

24 Apr 2008

Pin1 is beneficial in Alzheimer's disease, detrimental to some forms of dementia

The most common form of dementia, Alzheimer's disease, and a relatively rare hereditary form of dementia, frontotemporal dementia with parkinsonism-17, share a common pathology: Both are the result of an overaccumulation of tau proteins, which form tangled lesions in the brain's neurons and eventually lead to the collapse of the brain cells responsible for memory.

22 Apr 2008

New understanding of systemic sclerosis

Systemic sclerosis (SSc), also known as scleroderma, is characterized by the formation of fibrosis, or scar tissue, on internal organs as well as the skin.

15 Apr 2008

Regulating hematopoietic stem cell homeostasis and leukemogenesis

In the April 15th issue of G&D, Dr. Richard Flavell (Yale University) and colleagues identify the c-Cbl protein as a critical repressor of hematopoietic stem cell (HSC) self-renewal.

15 Apr 2008

Cancer prevention

Tapping into a growing body of knowledge about the origins and progression of cancer, researchers are now developing and testing new preventive therapies to stop it in its tracks.

15 Apr 2008

Biomarkers allow doctors to match therapy to patient

Genetic variations ensure that no two people are exactly alike, nor are their cancers.

13 Apr 2008

T-cell multiplication unexpectedly delayed after infection

In a surprising outcome that overturns the conventional wisdom on the body's immune response to infection, scientists at The Scripps Research Institute have shown that T cells do not begin proliferation until up to three days after infection.

11 Apr 2008

A polyphenols-rich diet keeps the heart younger

This finding comes out from a study by the University of Grenoble in collaboration with the other Centres participating to the FLORA Project, a European Commission funded research studying the effects of flavonoids, a variety of polyphenols, on human health.

24 Mar 2008

Cause of prolonged penile erection

Priapism (prolonged penile erection in the absence of sexual interest) is common in male individuals with sickle cell disease (SCD), a blood disorder characterized by abnormally shaped red blood cells.

14 Mar 2008

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

A gene crucial for embryonic development can quickly become a potent cancer promoter in adult mice after a genetic misalignment, according to researchers from Fox Chase Cancer Center, causing white blood cells to become cancerous spontaneously.

28 Feb 2008

Mutation in TDP-43 gene may play role in common dementia

Scientists at Washington University School of Medicine in St. Louis have linked a mutation in a gene known as TDP-43 to an inherited form of amyotrophic lateral sclerosis (ALS), the neurodegenerative condition often called Lou Gehrig's disease.

21 Feb 2008

Risk factors for Parkinson's disease focus of new research

A new study demonstrates that high levels of MAO-B, an enzyme that regulates nerve activity in the brain, cause Parkinson's-like symptoms in mice genetically engineered to overexpress the protein.

20 Feb 2008

Two-way cell talk provides clues about neuromuscular disease

It's a scientific given that neurons tell other cells what to do, but new evidence suggests that, like with any good relationship, these target cells also have much to contribute, scientists say.

17 Feb 2008

Maslinic acid from olives shows anti-cancer properties

A research group of the University of Granada has found out that maslinic acid, a compound present in the leaf and the olive skin wax extracted from alpeorujo (crushed olive pulp), has the capacity of preventing cancer as well as regulating apoptosis in carcinogenic processes.

14 Feb 2008

Setting up a roadblock for atherosclerosis

Myriocin kills bacteria by disrupting the formation sphingomyelin, a fatty molecule that is a key part of their cell membranes.

8 Feb 2008

Microscopic imaging technique reveals rapid formation of Alzheimer's-associated plaques

The amyloid plaques found in the brains of Alzheimer's disease patients may form much more rapidly than previously expected.

7 Feb 2008

Molecular evolution of limb length

In the January 15th issue of G&D, a research team led by Dr. Richard Behringer at MD Anderson Cancer Center reports that they have successfully switched the mouse Prx1 gene regulatory element with the Prx1 gene regulatory region from a bat - and although these two species are separated by millions of years of evolution - the resulting transgenic mice displayed abnormally long forelimbs.

15 Jan 2008

High blood pressure gene found

Scientists have identified the gene that sets off a sequence of events in the blood vessels of otherwise healthy adults that can lead to high blood pressure.

11 Jan 2008

Novel mechanism for long-term learning identified

Practice makes perfect - or at least that's what we're told as we struggle through endless rounds of multiplication tables, goal kicks and piano scales - and it seems, based on the personal experience of many, to be true.

4 Jan 2008