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Gene variants may provide clues to successful treatment of pediatric eosinophilic esophagitis

A group of three gene variants, commonly inherited together, may provide clues to more successful treatment of pediatric eosinophilic esophagitis (EoE), a chronic inflammation of the food pipe often confused with gastroesophageal reflux disease (GERD).

16 Oct 2020

Exposure to ancient parasites may be linked to humans’ response to coronavirus

Why are some people more resilient to viruses than others? The answer has eluded scientists for centuries and, in the age of COVID-19, has come to represent one of the holy grails of biomedical research.

16 Oct 2020

Scientists reveal host pathways hijacked by three lethal coronaviruses

Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three.

16 Oct 2020

Early trauma leads to changes in blood metabolites, study finds

A study by the Brain Research Institute at UZH reveals that early trauma leads to changes in blood metabolites - similarly in mice and humans.

15 Oct 2020

NIH grants 4D Nucleome award to support research by Gladstone scientists

The National Institutes of Health has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, PhD, and Katie Pollard, PhD.

15 Oct 2020

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Researchers identify circulating proteins influencing COVID-19 susceptibility and severity by employing a large-scale two-sample Mendelian randomization (MR) study.

15 Oct 2020

Cocaine use in mice leads to the formation of synapses by astrocytes

Drugs of abuse, like cocaine, are so addictive due in part to their cellular interaction, creating strong cellular memories in the brain that promote compulsive behaviors.

15 Oct 2020

New technology precisely diagnoses sickle cell disease in a minute

Researchers at the University of Colorado Boulder and the University of Colorado Anschutz Medical Campus have developed a new way to diagnose diseases of the blood like sickle cell disease with sensitivity and precision and in only one minute.

15 Oct 2020

UCI-led researchers receive $3 million NIH grant for 4D Nucleome project

The National Institutes of Health has awarded a team of researchers, led by the University of California, Irvine's Xiangmin Xu, PhD, a five-year, $3 million grant for a project titled, "Single-Cell Analysis of Aging-Associated 4D Nucleome in the Human Hippocampus."

15 Oct 2020

Small molecule restores normal heart development in animal model with rare genetic disorder

A research team at the Greenwood Genetic Center has successfully used small molecules to restore normal heart and valve development in an animal model for Mucolipidosis II (ML II), a rare genetic disorder. Progressive heart disease is commonly associated with ML II.

15 Oct 2020

Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

In a recent paper available on the bioRxiv preprint server, US researchers show that individual particles of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergo structural destabilization at relatively mild but elevated temperatures – strengthening the case for coronavirus disease (COVID-19) resurgence in the winter.

15 Oct 2020

Small RNA molecule controls major pathogenicity factors of H. pylori

More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer.

15 Oct 2020

Researchers identify potential drugs that could be repurposed as pan-coronavirus treatments

A large international consortium of almost 200 researchers from 14 leading institutions in six countries has studied three different coronaviruses - SARS-CoV-1, SARS-CoV-2, and MERS-CoV - with the aim of finding vulnerabilities shared by these three pathogens.

15 Oct 2020

Experts to address factors that cause low dairy consumption in low- and middle-income countries

Low dairy consumption is common among low- and middle-income countries (LMICs); however, with the demand for milk in these countries projected to increase over the next few decades, there is an opportunity to improve the lives of millions of people from the nutritional benefits of dairy products.

15 Oct 2020

Researchers engineer cow muscle cells to produce plant nutrients

A group of researchers at Tufts University have genetically engineered cow muscle cells to produce plant nutrients not natively found in beef cells.

15 Oct 2020

SARS-CoV-2 can infect brain cells and damage neurons

Researchers have found that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the brain cells, mainly the astrocytes, and negatively affects cognition and neuronal cells.

15 Oct 2020

New saliva tests can enable early detection and diagnosis of COVID-19, head & neck cancer

Summit Biolabs, Inc., an early-stage molecular diagnostics company specializing in saliva-based testing for COVID-19 and head & neck cancer, and the Colorado Center for Personalized Medicine (CCPM) at the University of Colorado Anschutz Medical Campus announced today a broad strategic collaboration involving research, development and commercialization of saliva liquid-biopsy tests for early cancer detection and diagnosis of COVID-19 and other viral contagions.

15 Oct 2020

People born with a heart defect have low risk of moderate or severe COVID-19 infection

Results of a retrospective analysis suggest that people born with a heart defect who developed COVID-19 symptoms had a low risk of moderate or severe COVID-19 infection, according to a new article published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

14 Oct 2020

Women with undiagnosed heart conditions at risk for pregnancy-related aortic dissection

In a time already full of challenges and changes, some pregnant and postpartum women will also experience a rare but dangerous heart complication: an aortic dissection.

14 Oct 2020

The COVID-19 vaccine pipeline

Researchers from Mayo Clinic, United States of America, have reviewed the immunity developed against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease.

14 Oct 2020

Genetic News and Research

Gene variants may provide clues to successful treatment of pediatric eosinophilic esophagitis

Exposure to ancient parasites may be linked to humans’ response to coronavirus

Scientists reveal host pathways hijacked by three lethal coronaviruses

Early trauma leads to changes in blood metabolites, study finds

NIH grants 4D Nucleome award to support research by Gladstone scientists

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Cocaine use in mice leads to the formation of synapses by astrocytes

New technology precisely diagnoses sickle cell disease in a minute

UCI-led researchers receive $3 million NIH grant for 4D Nucleome project

Small molecule restores normal heart development in animal model with rare genetic disorder

Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

Small RNA molecule controls major pathogenicity factors of H. pylori

Researchers identify potential drugs that could be repurposed as pan-coronavirus treatments

Experts to address factors that cause low dairy consumption in low- and middle-income countries

Researchers engineer cow muscle cells to produce plant nutrients

SARS-CoV-2 can infect brain cells and damage neurons

New saliva tests can enable early detection and diagnosis of COVID-19, head & neck cancer

People born with a heart defect have low risk of moderate or severe COVID-19 infection

Women with undiagnosed heart conditions at risk for pregnancy-related aortic dissection

The COVID-19 vaccine pipeline

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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