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Thiopurines could help stop viral replication in human coronaviruses

Researchers from the Department of Microbiology & Immunology, Dalhousie University, University of Calgary, and Department of Biochemistry and Molecular Biology, University of British Columbia, Canada, worked with human coronaviruses in cell cultures to look for drugs that might prevent accumulation and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Oct 2020

Study confirms SARS-CoV-2 spike glycoprotein promotes a hyper-inflammatory immune response

A group of researchers from Australia and China recently demonstrated how SARS-CoV-2 spike glycoprotein subunit 1 can induce a pro-inflammatory signaling pathway (leading to cytokines deployment and epithelial damage in human bronchial epithelial cells), but also highlighted the potential of peptide-based antivirals in tackling this novel coronavirus.

5 Oct 2020

Most Australians favourable to a COVID-19 vaccination

Now, a new study published on the preprint server medRxiv* by scientists at the University of New South Wales aimed to determine the public perfections regarding a future COVID-19 vaccine in Australia. They wanted to know if Australians would get the vaccine if one becomes available.

5 Oct 2020

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Preliminary results from two independent, phase II clinical trials investigating a new PD-1 (programmed cell death protein 1)-based immune therapy for metastatic cervical cancer suggest potential new treatment options for a disease that currently has limited effective options and disproportionately impacts younger women.

5 Oct 2020

Understanding how the malaria parasite can withstand fever's heat

Even when a person suffering from malaria is burning up with fever and too sick to function, the tiny blood-eating parasites lurking inside them continue to flourish, relentlessly growing and multiplying as they gobble up the host's red blood cells.

5 Oct 2020

New deep learning-based technique could boost drug development

When you take a medication, you want to know precisely what it does. Pharmaceutical companies go through extensive testing to ensure that you do.

5 Oct 2020

Study compares antibiotic therapy with surgery in patients with appendicitis

Results of a first-of-its-kind clinical trial shed light on when antibiotics instead of surgery might be the better choice for treating appendicitis in some patients, according to researchers with The University of Texas Health Science Center at Houston, who led the Houston trial sites.

5 Oct 2020

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

A team of researchers in the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, Cleveland Clinic, and Cedars-Sinai Medical Center, were recently awarded a $3.2 million grant from the National Institutes of Health to enhance research for improving heart transplant outcomes for patients.

5 Oct 2020

FDA and Mexican regulatory counterparts strengthen partnership on food safety

Today, during a virtual ceremony, the U.S. Food and Drug Administration and its regulatory counterparts in Mexico - the Federal Commission for the Protection from Sanitary Risks and the National Service of Agro-Alimentary Health, Safety and Quality - enhanced a partnership to work together on food safety in both countries.

5 Oct 2020

Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib.

5 Oct 2020

A new method to deliver drugs to the brain with pinpoint accuracy

Focused ultrasound waves help ETH researchers to deliver drugs to the brain with pinpoint accuracy, in other words only to where their effect is desired. This method is set to enable treatment of psychiatric and neurological disorders and tumors with fewer side effects in the future.

5 Oct 2020

Scientists discover small molecules that may reduce cellular stress

For many, getting older can unfortunately mean an increased risk of illness from cardiovascular disease to cancer.

5 Oct 2020

Will COVID-19 become a seasonal virus?

In this interview, Dr. Hadi Yassine and Dr. Hassan Zaraket speak about their research into whether COVID-19 will become a seasonal virus.

5 Oct 2020

New approach transforms oldest antibiotics into safer, stronger drugs

Physicians and scientists have long searched the natural world for chemicals that can improve human health. However, evolutionary selection optimized natural chemicals to benefit their host, not for safety or efficacy in humans.

5 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

SGD Pharma extends industry-leading Ready-to-Use molded glass vial range with introduction of EasyLyo and ISO20mm 50ml sizes in tray

SGD Pharma extends leading glass vial range with new sizes

From SGD Pharma 2 Oct 2020

Study offers explanation for why people's responses to the same drug vary widely

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

1 Oct 2020

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

PATH announced today they received a grant from Japan's Global Health Innovative Technology Fund to develop a new oral treatment option for soil-transmitted helminth infections.

1 Oct 2020

Study examines the impact of Viagra drug advertising on birth rates

Many marketing studies have examined the impact of direct-to-consumer advertising of pharmaceuticals on sales and market shares. But in a new study, a researcher from The University of Texas at Dallas wanted to know whether drug advertising might have some unintended, population-level health consequences.

1 Oct 2020

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and The Ohio State University College of Veterinary Medicine have been awarded a five-year, $9.1 million grant Program Project Grant renewal from the National Cancer Institute.

1 Oct 2020

Drugs News and Research

Thiopurines could help stop viral replication in human coronaviruses

Study confirms SARS-CoV-2 spike glycoprotein promotes a hyper-inflammatory immune response

Most Australians favourable to a COVID-19 vaccination

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Understanding how the malaria parasite can withstand fever's heat

New deep learning-based technique could boost drug development

Study compares antibiotic therapy with surgery in patients with appendicitis

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

FDA and Mexican regulatory counterparts strengthen partnership on food safety

Potential drug treatment for AXL-low expressing EGFR-mutated lung cancer

A new method to deliver drugs to the brain with pinpoint accuracy

Scientists discover small molecules that may reduce cellular stress

Will COVID-19 become a seasonal virus?

New approach transforms oldest antibiotics into safer, stronger drugs

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

SGD Pharma extends industry-leading Ready-to-Use molded glass vial range with introduction of EasyLyo and ISO20mm 50ml sizes in tray

Study offers explanation for why people's responses to the same drug vary widely

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

Study examines the impact of Viagra drug advertising on birth rates

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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