Immune System News and Research

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Study sheds light on development of ILCs that play vital role in body's immune defense

Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases have found that the development of immune cells, called innate lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection. This work, which appeared online today in Cell, sheds light on the development and function of a cell type that is increasingly recognized as having an important role in the body's immune defense. NIAMS is part of the National Institutes of Health.

6 May 2016

Bim protein may hold clue for immunotherapy response in metastatic melanoma patients

A protein called Bim may hold the clue to which patients may be successful on immunotherapy for metastatic melanoma, according to the results of a study by Mayo Clinic researchers led by senior author Haidong Dong, M.D., Ph.D., and published online in the May 5 edition of JCI Insight.

6 May 2016

Female sex hormone estradiol may protect women against sexually transmitted viral infections

A team of researchers led by McMaster University's Charu Kaushic has revealed for the first time how estradiol, a female sex hormone present during the menstrual cycle and found in oral contraceptives, may work to protect women against sexually transmitted viral infections.

6 May 2016

Implantable brain device shows promising results in animal study

An implantable brain device that literally melts away at a pre-determined rate minimizes injury to tissue normally associated with standard electrode implantation, according to research led by a team from the Perelman School of Medicine at the University of Pennsylvania.

6 May 2016

Duke scientists develop human-derived antibody that preferentially attacks cancer cells

A research team from Duke Health has developed an antibody from the body's own immune system that preferentially attacks cancer cells.

6 May 2016

UA researchers one step closer to preventing asthma in children

Efforts to improve the health of children at increased risk for asthma will receive a major boost with the launch of a new University of Arizona Health Sciences-led, federally funded national clinical study. For Fernando D. Martinez, MD, and his colleagues at the UA Asthma and Airway Disease Research Center, this study follows 30 years of research to prevent and cure this chronic disease.

6 May 2016

Common misconception about penicillin allergies

It's time for your primary care check-up, and the doctor asks you to list any known drug allergies. "Penicillin," you say immediately, although you can't remember actually taking the drug or having a reaction to it—it was your parents who said so. According to a Texas A&M Health Science Center allergist, many people who believe they're allergic to this antibiotic may not actually be allergic at all.

5 May 2016

Older adults become more sensitive to pain, study shows

When older relatives complain about their pains, show a little empathy, because new research suggests that as we age, we may all become more sensitive to pain. A small, preliminary University of Florida Health study has suggested for the first time that inflammation may occur more quickly and at a higher magnitude -- and stays around longer -- when older adults experience pain versus when younger adults experience pain.

5 May 2016

Scientists discover how immune system molecule hijacks brain circuit to reduce appetite during illness

Loss of appetite during illness is a common and potentially debilitating phenomenon--in cancer patients, especially, it can even shorten lifespan.

5 May 2016

ITJ researchers develop new hydrating beverage for athletes

Jiquiquilpan's Institute of Technology in Mexico developed a hydrating beverage for athletes that is based on agave's fructans, that not only supplies the adequate water levels to the organisms, but also offers other benefits such as dietetic fiber.

5 May 2016

Enzyme previously thought beneficial could pose threat to developing embryos

A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have implications not only for prenatal development but also for treating lymphedema and liver damage resulting from acetaminophen overdose.

5 May 2016

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine.

5 May 2016

Early viral respiratory infections may increase type 1 diabetes risk in children

Viral respiratory infections during the first six months of life are associated with an increased risk for type 1 diabetes. This is the conclusion reached by a team of scientists at the Helmholtz Zentrum München during a study published in the current issue of the renowned US magazine 'JAMA'.

5 May 2016

Researchers develop computer model to reveal how antibiotic-resistant microbes develop and spread

Researchers from the Scientific Research Institute of Physical-Chemical Medicine, MIPT, the company M&S Decisions and the research department of Yandex have built a computer model of the interaction between different bacteria, and between bacteria and the gut wall.

5 May 2016

Human milk hormones may play vital role in shaping healthy infant microbiome

A new University of Colorado Anschutz Medical Campus study finds that hormones in breast milk may impact the development of healthy bacteria in infants' guts, potentially protecting them from intestinal inflammation, obesity and other diseases later in life.

5 May 2016

Candida yeast infections more common in men with schizophrenia or bipolar disorder

In a study prompted in part by suggestions from people with mental illness, Johns Hopkins researchers found that a history of Candida yeast infections was more common in a group of men with schizophrenia or bipolar disorder than in those without these disorders, and that women with schizophrenia or bipolar disorder who tested positive for Candida performed worse on a standard memory test than women with schizophrenia or bipolar disorder who had no evidence of past infection.

4 May 2016

Researchers find gene variants that predict adverse effects of hyperthyroidism drugs

Researchers and doctors at Uppsala University, along with Swedish and international collaboration partners, have found gene variants that predict the risk of a serious adverse reaction to drugs used for the treatment of hyperthyroidism. The results are published in The Lancet Diabetes & Endocrinology.

4 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Respiratory tract infection in infants linked with increased T1D risk

In a study appearing in the May 3, 2016 issue of JAMA, Anette-Gabriele Ziegler, M.D., of Helmholtz Zentrum Munchen, Munich, Germany, and colleagues examined associations between infection types during the first 2 years of life and between respiratory tract infections in the first 6 months and type l diabetes (T1D). Viral infections, particularly enteroviruses, have been hypothesized to cause T1D. Recent studies suggest that respiratory tract infections are associated with increased T1D risk if they are encountered within the first 6 months.

4 May 2016

Scientists detect blood biomarker that may help in early diagnosis of children with ASD

Researchers at UT Southwestern Medical Center have identified a blood biomarker that may aid in earlier diagnosis of children with autism spectrum disorder, or ASD.

4 May 2016

Immune System News and Research

Study sheds light on development of ILCs that play vital role in body's immune defense

Bim protein may hold clue for immunotherapy response in metastatic melanoma patients

Female sex hormone estradiol may protect women against sexually transmitted viral infections

Implantable brain device shows promising results in animal study

Duke scientists develop human-derived antibody that preferentially attacks cancer cells

UA researchers one step closer to preventing asthma in children

Common misconception about penicillin allergies

Older adults become more sensitive to pain, study shows

Scientists discover how immune system molecule hijacks brain circuit to reduce appetite during illness

ITJ researchers develop new hydrating beverage for athletes

Enzyme previously thought beneficial could pose threat to developing embryos

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Early viral respiratory infections may increase type 1 diabetes risk in children

Researchers develop computer model to reveal how antibiotic-resistant microbes develop and spread

Human milk hormones may play vital role in shaping healthy infant microbiome

Candida yeast infections more common in men with schizophrenia or bipolar disorder

Researchers find gene variants that predict adverse effects of hyperthyroidism drugs

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Respiratory tract infection in infants linked with increased T1D risk

Scientists detect blood biomarker that may help in early diagnosis of children with ASD

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