Immune System News and Research

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Study shows aging affects adaptive immune responses

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Jeffrey Ebersole, University of Kentucky, Lexington, USA, will present a study titled "Systemic Antibody Responses to Oral Bacteria with Aging." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

21 Mar 2016

Aging-associated changes begin earlier than expected in human brain

A new study published in Physiological Genomics suggests that the brain shows signs of aging earlier than old age. The study found that the microglia cells—the immune cells of the brain—in middle-aged mice already showed altered activity seen in microglia from older mice.

21 Mar 2016

Researchers describe generation of plasma cell-specific antibody from immunized lampreys

Antibody-secreting plasma cells arise from B cell precursors and are essential for adaptive immune responses against invading pathogens. Plasma cell dysfunction is associated with autoimmune and neoplastic disorders, including multiple myeloma.

21 Mar 2016

New study provides insight into HIV-dependent immune dysfunction

HIV infection results in a variety of immune abnormalities, which are especially pronounced in individuals with high viral titers. B cells are the antibody producing cells of the immune system and are not directly infected by HIV.

21 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

19 Mar 2016

Newly developed computer models can simulate stem cell transplant recovery

Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.

18 Mar 2016

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Cedars-Sinai research scientists have found that immune cells in the brain play a direct role in the development of amyotrophic lateral sclerosis, or ALS, offering hope for new therapies to target the neurodegenerative disease that gradually leads to paralysis and death.

18 Mar 2016

Findings could be final puzzle piece in developing effective dengue vaccine

In a small clinical trial led by the Johns Hopkins Bloomberg School of Public Health, researchers say that a promising single-dose dengue vaccine, developed by scientists at the National Institutes of Health, was 100 percent effective in preventing human volunteers from contracting the virus, the most prevalent mosquito-borne virus in the world.

18 Mar 2016

Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

As key players in the immune system, T cells provide tumor surveillance and have direct antitumor effects. However, tumors can escape T-cell attack through various mechanisms in the tumor microenvironment. Reactivating the antitumor effects of T cells has shown great clinical benefits in treating various cancers.

18 Mar 2016

EPFL scientists develop cutting-edge treatment for Alzheimer's disease

In a cutting-edge treatment for Alzheimer's disease, EPFL scientists have developed an implantable capsule that can turn the patient's immune system against the disease.

18 Mar 2016

New subtype of bladder cancer shares molecular signatures with breast cancer

Bladder cancer is the fourth most common cancer among men in the United States. While low-grade tumors have a very favorable prognosis, muscle-invasive and metastatic tumors have poorer survival rates.

17 Mar 2016

Molecular basis for tongue cancer progression: an interview with Dr Simona Principe

Head and neck cancers (HNC) are the sixth most common cancers worldwide, with approximately 600,000 new cases diagnosed every year.

From Beckman Coulter Life Sciences - Centrifugation 17 Mar 2016

Psoriasis patients experience widespread bone loss

Researchers from the Genes, Development and Disease Group, headed by Erwin Wagner at the Spanish National Cancer Research Centre have discovered that psoriasis patients experience a widespread bone loss as a result of the disease.

17 Mar 2016

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

17 Mar 2016

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.

17 Mar 2016

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs — known primarily for their cholesterol-lowering effects — can significantly reduce the time it takes to clear tuberculosis infection.

17 Mar 2016

Research shows probiotic B. longum KACC 91563 has ability to reduce effects of food allergies

Lactobacillus might sound familiar when the topic of probiotics comes up, but they are only one of many types of bacteria that have proven health benefits.

16 Mar 2016

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Galacto-oligosaccharides are essentially sugar or saccharide molecules that have been joined together into short polymer chains.

16 Mar 2016

Caloric restriction leads to fatale weakening of the immune system

It's already well known that a diet may have a life-extending effect. Researchers from Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, now showed that besides improving the functionality of stem cells in mice, a caloric restriction also leads to a fatale weakening of their immune system - counteracting the life-lengthening effect of a diet.

16 Mar 2016

Immune System News and Research

Study shows aging affects adaptive immune responses

Aging-associated changes begin earlier than expected in human brain

Researchers describe generation of plasma cell-specific antibody from immunized lampreys

New study provides insight into HIV-dependent immune dysfunction

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Newly developed computer models can simulate stem cell transplant recovery

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Findings could be final puzzle piece in developing effective dengue vaccine

Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

EPFL scientists develop cutting-edge treatment for Alzheimer's disease

New subtype of bladder cancer shares molecular signatures with breast cancer

Molecular basis for tongue cancer progression: an interview with Dr Simona Principe

Psoriasis patients experience widespread bone loss

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

Research shows probiotic B. longum KACC 91563 has ability to reduce effects of food allergies

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Caloric restriction leads to fatale weakening of the immune system

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