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ChemGenex Pharmaceuticals presents clinical results of Omapro drug at ASH meeting

ChemGenex Pharmaceuticals Limited (ASX:CXS) announced today updated clinical data showing that Omapro™ (omacetaxine mepesuccinate) produced durable hematologic and cytogenetic responses in chronic myeloid leukemia (CML) patients who have failed treatment with imatinib and who have developed the Bcr-Abl T315I mutation.

7 Dec 2009

New approach to protein misfolding may lead to novel therapies for a number of diseases

In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis. While there is still much work to be done before the therapy can be tested in humans, the discovery opens the door to a new class of therapies for this and a host of other chronic diseases.

7 Dec 2009

New study reveals genetic alteration can lead to severe childhood obesity

Scientists in Cambridge have discovered that the loss of a key segment of DNA can lead to severe childhood obesity. This is the first study to show that this kind of genetic alteration can cause obesity. The results are published today in Nature.

6 Dec 2009

New treatment options for leukemia and myeloproliferative disorders introduced

Leukemia and myeloproliferative disorders are serious and often deadly blood cancers. Research presented today at the 51st Annual Meeting of the American Society of Hematology introduces potential new treatment options and improved diagnostic methods for patients suffering from acute promyelocytic leukemia, chronic myeloid leukemia, infant acute lymphoblastic leukemia, and myelofibrosis that are based on a better understanding of the underlying genetic causes of these conditions.

6 Dec 2009

Pre-clinical study data of Stemline Therapeutics' IL-3R targeting agents to be presented at the ASH meeting

Stemline Therapeutics, Inc. today announced that data from pre-clinical studies of its IL-3R targeting agents, SL-401 and SL-501, in both in vitro and animal models of human chronic myeloid leukemia (CML) have been selected for poster presentation at the upcoming 51st Annual Meeting of the American Society of Hematology (ASH), to be held in New Orleans from December 5-8, 2009.

4 Dec 2009

New discoveries to treat life-threatening blood disorder presented at ASH annual meeting

A genetic variation that may indicate a patient's risk of developing a potentially life-threatening blood disorder if exposed to certain pharmaceutical therapies or chemicals is one of several medical discoveries scientists at cancer diagnostics leader Quest Diagnostics will present during the 51st American Society of Hematology (ASH) Annual Meeting and Exposition, December 5-8, 2009, in New Orleans, LA.

4 Dec 2009

Researchers discover mechanism that explains how chromosomal translocations are not random

Researchers at the UC San Diego School of Medicine have pinpointed a mechanism that may help explain how chromosomal translocations - the supposedly random shuffling of large chunks of DNA that frequently lead to cancer - aren't so random after all. They have developed a model of such chromosomal mix-ups in prostate cancer which indicates that the male sex hormone (androgen) receptor unexpectedly plays a key role in driving specific translocations in the development of cancer.

4 Dec 2009

Research study shows usage of stem cell-based therapies for treating age-related macular degeneration

An international team of scientists has rescued visual function in laboratory rats with eye disease by using cells similar to stem cells. The research shows the potential for stem cell-based therapies to treat age-related macular degeneration in humans.

4 Dec 2009

New step in the proofreading process that helps maintain accuracy of DNA replication identified

Wayne State researchers have for the first time observed the movement of a single molecule of DNA polymerase as it incorporates nucleotides one by one. More significantly, they have identified a previously unknown step that they speculate is part of the proofreading process known to prevent the polymerase from producing cancer-causing mutations.

4 Dec 2009

Scientists discover mechanism by which E6 oncoprotein of high-risk HPV16 promotes carcinogenesis

In the 1980s, Harald zur Hausen and his co-workers discovered that specific types of human papillomavirus (HPV) cause cervical cancer. Scientists soon found out how these pathogens cause cells to degenerate. It is known today that the main culprits are viral proteins E6 and E7. Both proteins switch off different cellular control functions, thus promoting cell growth.

4 Dec 2009

Two antimicrobial drug developing companies evaluate new approach for treating bacterial infections

Chaperone Technologies, Inc. and MerLion Pharmaceuticals Pte Ltd., both privately-held companies developing new antimicrobial drugs, announced today that they are together evaluating a unique approach for the treatment of resistant and life-threatening bacterial infections.

4 Dec 2009

Genetic differences determine intensity of people's responses to social rejection

Scientists have long known that opium-like painkillers, called opioids, relieve not only physical pain, but also some forms of emotional stress. Now, a new study reviewed by Faculty of 1000 Biology member Markus Heilig shows that small genetic differences in the gene for the opioid receptor can determine the intensity of people's responses to social rejection.

4 Dec 2009

Discovery of antibiotic molecule may lead to the development of potent antibacterial drugs

An antibiotic that binds to a well-established target in a novel and unexpected way could be the inspiration for designing new, more potent antibacterial drugs.

4 Dec 2009

Roche to provide the RealTime ready Influenza A/H1N1 Detection Set to CLIA high-complexity labs under EUA

The Roche assay for the 2009 H1N1 influenza virus detects RNA from the 2009 H1N1 Influenza A virus and provides a rapid means of identification of patients infected with this virus. In order to ensure continued specificity and sensitivity of the Roche's Influenza A/H1N1 assay, Roche performs sequence comparisons with all available 2009 H1N1 Influenza Virus sequences on a regular basis.

3 Dec 2009

Novel multi-analyte approach to develop urine-biomarker based diagnostic assay to be presented

Predictive Biosciences today announced that Company scientists will be presenting a novel multi-analyte approach to the development of a non-invasive, urine-biomarker based diagnostic assay during the 10th Annual Meeting of the Society of Urologic Oncology (SUO).

3 Dec 2009

Manpei Suzuki Diabetes Foundation announces the 2009 winner of International Prize

The Manpei Suzuki Diabetes Foundation is pleased to announce the 2009 winner of the International Prize: Donald F. Steiner, MD, A. N. Pritzker Distinguished Service Professor Emeritus, Departments of Medicine and Biochemistry and Molecular Biology, The University of Chicago, USA.

3 Dec 2009

Genta to supply Ganite for new CF clinical trial

Genta Incorporated announced that the Company will supply Ganite® (gallium nitrate injection) for a new clinical trial that will be initiated in patients with cystic fibrosis (CF) who may develop serious infections.

2 Dec 2009

NHLBI awards stimulus funds for hemophilia drug research

PTC Therapeutics, Inc. (PTC) today announced the receipt of a $1 million Challenge Grant award from the National Heart, Lung, and Blood Institute (NHLBI) as part of the National Institutes of Health (NIH).

2 Dec 2009

Cancer Genomic Microarray Facility selects febit's Geniom RT Analyzer to advance its biomedical research

The Cancer Genomic Microarray Facility at the Kimmel Cancer Center of the Thomas Jefferson University, Philadelphia, selected febit's Geniom® RT Analyzer to advance its biomedical research by proceeding targeted Next-Generation Sequencing (NGS), genome-wide single nucleotide polymorphism (SNP) and microRNA (miRNA) analysis.

2 Dec 2009

Study identifies genetic link between vitamin D and heart disease

Previous studies have shown a link between low vitamin D status and heart disease. Now a new study shows that patients with high blood pressure who possess a gene variant that affects an enzyme critical to normal vitamin D activation are twice as likely as those without the variant to have congestive heart failure.

2 Dec 2009

Mutation News and Research

ChemGenex Pharmaceuticals presents clinical results of Omapro drug at ASH meeting

New approach to protein misfolding may lead to novel therapies for a number of diseases

New study reveals genetic alteration can lead to severe childhood obesity

New treatment options for leukemia and myeloproliferative disorders introduced

Pre-clinical study data of Stemline Therapeutics' IL-3R targeting agents to be presented at the ASH meeting

New discoveries to treat life-threatening blood disorder presented at ASH annual meeting

Researchers discover mechanism that explains how chromosomal translocations are not random

Research study shows usage of stem cell-based therapies for treating age-related macular degeneration

New step in the proofreading process that helps maintain accuracy of DNA replication identified

Scientists discover mechanism by which E6 oncoprotein of high-risk HPV16 promotes carcinogenesis

Two antimicrobial drug developing companies evaluate new approach for treating bacterial infections

Genetic differences determine intensity of people's responses to social rejection

Discovery of antibiotic molecule may lead to the development of potent antibacterial drugs

Roche to provide the RealTime ready Influenza A/H1N1 Detection Set to CLIA high-complexity labs under EUA

Novel multi-analyte approach to develop urine-biomarker based diagnostic assay to be presented

Manpei Suzuki Diabetes Foundation announces the 2009 winner of International Prize

Genta to supply Ganite for new CF clinical trial

NHLBI awards stimulus funds for hemophilia drug research

Cancer Genomic Microarray Facility selects febit's Geniom RT Analyzer to advance its biomedical research

Study identifies genetic link between vitamin D and heart disease

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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