Immune System News and Research

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New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

20 Apr 2016

Two Ebola vaccine candidates show promise in clinical trial

An immunization regimen using two Ebola vaccine candidates was safe and well-tolerated and induced an immune response in healthy adult volunteers in a Phase 1 clinical trial.

20 Apr 2016

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers from VIB-UGent reveal that adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and self-maintenance capacities as macrophages of embryonic origin.

20 Apr 2016

Researchers develop new mathematical model to evaluate best treatment protocol to clear infection

Antibiotic resistance is one of the most challenging problems in modern medicine. A new study by Erida Gjini and Patricia H. Brito from the Instituto Gulbenkian de Ciência, provides a new mathematical model to evaluate the best treatment protocol to clear an infection, by taking into account the role of the host immune system.

20 Apr 2016

Study evaluates influence of midwife-led antenatal care on VBAC rates

Women who had a caesarean section in a previous pregnancy are much more likely to have a safer vaginal birth if their antenatal care is led by a midwife, according to a new study from The University of Manchester.

20 Apr 2016

New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

A clinical study evaluating a new hypothesis that an inexpensive drug with a simple treatment regimen can prevent type 1 diabetes will be launched in Dundee tomorrow.

20 Apr 2016

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

20 Apr 2016

Study shows beneficial effect of hNSC transplantation for TBI

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. Treatment is limited to supportive care, but stem cell therapy has received recent attention as a way to promote recovery for injuries to the central nervous system (CNS). In this study, researchers transplanted human neural stem cells (hNSCs) into the brains of mice modeled with TBI to investigate whether the hosts' immune systems and the stem cells acting in concert would enhance repair.

20 Apr 2016

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

20 Apr 2016

Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

Putting just a tiny piece of the wall of detoxified E. coli into their gut make mice lose their natural sweet tooth, researchers report.

20 Apr 2016

Scientists identify underlying cause of immune suppression in people with high level spinal cord injuries

Scientists report in Nature Neuroscience they have identified an underlying cause of dangerous immune suppression in people with high level spinal cord injuries and they propose a possible treatment.

19 Apr 2016

Researchers focus on novel target to treat bacterial infection

Bacterial infection takes hold in the body when a pathogenic microorganism delivers toxins to healthy cells. One way bacteria accomplish this is by releasing vesicles, which act as tiny envelopes transporting toxins and other virulence factors to host cells. These toxins allow the bacteria to "make themselves at home" in cells.

19 Apr 2016

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology.

19 Apr 2016

Study describes precise mechanisms that enable TB bacteria to persist in the body

Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and published online April 18 in Nature Immunology.

19 Apr 2016

Cyclodextrin offers potential new therapy for cardiovascular disease

An American mother's hunch might result in new treatments for patients who can't tolerate conventional cholesterol-lowering drugs.

19 Apr 2016

Study points to novel way to treat diabetes in some patients

Blocking the hormone that raises sugar levels in the blood could increase insulin levels while keeping blood sugar levels down.

19 Apr 2016

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

Penn researchers report results of CAR therapy trial in brain cancer patients

Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumors, researchers from Penn Medicine and Harvard University reported at the AACR Annual Meeting 2016.

19 Apr 2016

Therapies based on alpha defensins could help treat rheumatoid arthritis

Arthritis and other inflammatory conditions could be helped by new insights into how the immune response is switched off.

19 Apr 2016

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response.

19 Apr 2016

Immune System News and Research

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Two Ebola vaccine candidates show promise in clinical trial

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers develop new mathematical model to evaluate best treatment protocol to clear infection

Study evaluates influence of midwife-led antenatal care on VBAC rates

New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

Study shows beneficial effect of hNSC transplantation for TBI

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Small piece of detoxified E. coli wall makes mice lose natural sweet tooth, study finds

Scientists identify underlying cause of immune suppression in people with high level spinal cord injuries

Researchers focus on novel target to treat bacterial infection

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Study describes precise mechanisms that enable TB bacteria to persist in the body

Cyclodextrin offers potential new therapy for cardiovascular disease

Study points to novel way to treat diabetes in some patients

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Penn researchers report results of CAR therapy trial in brain cancer patients

Therapies based on alpha defensins could help treat rheumatoid arthritis

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Understanding the DNA Damage Response in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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