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Heparanase 2 emerges as key protector of blood vessel integrity

An international research team led by MDI Biological Laboratory President Hermann Haller, M.D. and postdoctoral researcher Yannic Becker, Ph.D. has discovered that a little-known molecule, heparanase 2 (Hpa2), plays a critical role in maintaining blood vessels' integrity.

2 Sep 2025

Epigenomic erosion linked to cognitive decline in Alzheimer’s patients

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins.

2 Sep 2025

Breakthrough reveals how viruses efficiently pack genetic material

Researchers at San Diego State University and Michigan State University are shedding new light on how viruses meticulously pack their genetic material - a breakthrough that could help researchers engineer antivirals and gene therapies.

2 Sep 2025

New technique succeeds in studying embryo implantation outside the body

The use of assisted reproductive technologies like in vitro fertilization is becoming more common worldwide. However, while these technologies successfully create viable embryos, a little over half of all embryos are lost because they fail to implant into the uterus.

2 Sep 2025

Nanostructures boost CRISPR delivery for genetic medicine

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach.

2 Sep 2025

Researchers discover a direct pathway for macrophage cleanup

Macrophages are part of the immune system's frontline; they attack and eat invaders to protect surrounding cells. They, along with other cells, maintain intracellular conditions through macroautophagy, using autophagosomes to help digest broken cell components.

2 Sep 2025

Research reveals molecular details of ME/CFS and long COVID

Patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) have heightened innate immune responses to bacteria, viruses, and fungi. While these responses are essential to fight infection, they can cause damage when unchecked.

1 Sep 2025

Glutamate receptors found to drive pediatric brain tumor development

The most common type of brain tumor in children, pilocytic astrocytoma (PA), accounts for about 15% of all pediatric brain tumors.

1 Sep 2025

Can honey protect your brain? Study reviews its potential against Alzheimer's

This review examined 27 preclinical studies on honey and Alzheimer’s disease, showing honey’s bioactive compounds counter oxidative stress, inflammation, and amyloid buildup. Despite promising lab results, no human trials exist, underscoring the need for clinical research.

1 Sep 2025

Why metformin could protect the brain by rewiring mitochondria

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its potential as a therapy for multiple sclerosis.

1 Sep 2025

Cancer-related nerve injury triggers inflammation and immunotherapy resistance

Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from The University of Texas MD Anderson Cancer Center.

1 Sep 2025

Genomic clues uncover early origins of multiple myeloma

A new study maps out the timeline of DNA damage for multiple myeloma, the second most common blood cancer.

1 Sep 2025

Scientists discover molecular brake that limits T cell attack on tumors

In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors.

1 Sep 2025

Ultra-processed foods affect sperm quality and metabolism even without extra calories

A controlled crossover trial in Cell Metabolism found that ultra-processed foods increase weight, fat mass, LDL:HDL cholesterol, and alter reproductive hormones in men, with some effects independent of calorie load. These diets also showed trends toward reduced sperm motility, shifts in pollutants, and transient inflammatory responses, highlighting risks beyond excess calories.

31 Aug 2025

Discovery of mitochondrial microprotein opens path to obesity and aging therapies

Like bees breathing life into gardens, providing pollen and making flowers blossom, little cellular machines called mitochondria breathe life into our bodies, buzzing with energy as they produce the fuel that powers each of our cells.

29 Aug 2025

New mouse models reveal mechanisms of RP59 retinal degeneration

Retinitis pigmentosa retinal degeneration is caused by a family of hereditary mutations in nearly 100 genes that slowly lead to blindness over years or decades.

29 Aug 2025

Transcription factors SP5 and SP8 regulate primary cilia formation in embryos

Some might say it looks like a finger. Others might see a worm. Scientists in the field often liken it to an antenna.

29 Aug 2025

Visualizing lipid transport inside living cells with fluorescence microscopy

Lipid molecules, or fats, are crucial to all forms of life. Cells need lipids to build membranes, separate and organize biochemical reactions, store energy, and transmit information.

29 Aug 2025

KAIST researchers develop universal technology to restore altered gene networks

Previously, research on controlling gene networks has been carried out based on a single stimulus-response of cells. More recently, studies have been proposed to precisely analyze complex gene networks to identify control targets.

29 Aug 2025

Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China

Cornelia de Lange syndrome (CdLS) is a rare genetic disorder with symptoms, including facial anomalies (such as fused eyebrows, short nose, upturned nose tip, and downturned mouth corners), growth retardation, small head (microcephaly), developmental delays, cognitive impairments, excess hair growth, and limb anomalies.

29 Aug 2025