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Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

Scientists develop preclinical model of scrub typhus disease

Scientists have developed an animal model of scrub typhus using outbred CD-1 mice. Using the model, they have characterized host susceptibility to the causative pathogen, disease pathogenesis, and immune responses. The study has been published in the journal PLOS Neglected Tropical Diseases.

27 Nov 2022

The potential of Sofosbuvir against COVID-19 neurological symptoms

Researchers discuss how SARS-CoV-2 infects cortical neurons and damages their synapses that form the connection between brain cells.

25 Nov 2022

Discovery could lead to new mantle cell lymphoma drugs

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

22 Nov 2022

Combination of ultrasound and nanobubbles enables the removal of tumors without surgery

A new technology developed at Tel Aviv University makes it possible to destroy cancerous tumors in a targeted manner, via a combination of ultrasound and the injection of nanobubbles into the bloodstream.

21 Nov 2022

CAR T-cell therapy in colorectal cancer

Researchers assessed the efficacy of CAR T-cells in the immunotherapy of colorectal cancer.

21 Nov 2022

New method can protect organs during heart and aortic surgery

Researchers led by Hidetoshi Masumoto and Genshiro Sunagawa at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have developed a new method of protecting organs during heart and aortic surgery when blood circulation has to be blocked.

20 Nov 2022

Study reveals novel therapeutic targets for airway relaxation

Bronchial constriction is what makes many lung diseases like asthma so dangerous. Researchers have discovered a new signaling pathway that causes the airways to widen.

17 Nov 2022

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

17 Nov 2022

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors.

16 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Scientists explore links between survival motor neuron protein and sarcopenia

Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.

15 Nov 2022

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

Currently, various classes of drugs are available for the treatment of mental illnesses - such as depression and anxiety disorders. However, although these drugs confer benefits, they are also associated with adverse side-effects.

15 Nov 2022

The viral fitness and antigenic relationship among Omicron sublineages

Researchers used mouse models and human airway cell cultures to investigate the relative viral replication rates and cross-neutralization against SARS-CoV-2 Omicron sublineages.

14 Nov 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022

Understanding the gut-brain connection in metabolic and neurological disorders

The community of microorganisms living in the human gut, known as the gut microbiome, is increasingly recognized as playing a pivotal role in metabolic conditions such as obesity and neurological diseases including Parkinson's disease.

9 Nov 2022

Researchers discover residual tumor cells responsible for colon cancer relapse

Colon cancer is the third most common cancer in the world, with about 2 million new cases each year. Most patients are diagnosed when the tumor is still located in the colon or rectum.

9 Nov 2022

Long-term effects of SARS-CoV-2 on the brain

More profoundly than previously believed, the virus that causes COVID-19, SARS-CoV-2, can impact the brain for months after infection.

9 Nov 2022

Can prostaglandin E2 injection improve hair growth?

A new study demonstrated that prostaglandin E2 (PGE2) stimulates hair follicle growth.

9 Nov 2022

Repeated emotional stress in mice provokes irritable bowel syndrome-like symptoms

The evidence for the interconnection between emotional states and intestinal conditions has grown recently. These findings have led researchers to speculate about the association between the brain and the gut – the "gut-brain axis."

9 Nov 2022

Mouse Model News and Research

Flavonoids with potential to fight allergies and inflammation

Scientists develop preclinical model of scrub typhus disease

The potential of Sofosbuvir against COVID-19 neurological symptoms

Discovery could lead to new mantle cell lymphoma drugs

Combination of ultrasound and nanobubbles enables the removal of tumors without surgery

CAR T-cell therapy in colorectal cancer

New method can protect organs during heart and aortic surgery

Study reveals novel therapeutic targets for airway relaxation

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Scientists explore links between survival motor neuron protein and sarcopenia

Researchers identify potential lead compounds for the treatment of neuropsychiatric disorders

The viral fitness and antigenic relationship among Omicron sublineages

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Understanding the gut-brain connection in metabolic and neurological disorders

Researchers discover residual tumor cells responsible for colon cancer relapse

Long-term effects of SARS-CoV-2 on the brain

Can prostaglandin E2 injection improve hair growth?

Repeated emotional stress in mice provokes irritable bowel syndrome-like symptoms

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