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Common laxative prucalopride may be useful as a pro-cognitive treatment in psychiatric conditions

Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects.

13 Jun 2023

Is the increased risk of bronchopulmonary dysplasia from high-dose docosahexaenoic acid supplementation in the neonatal period associated with changes to IQ?

Study analyzed whether a reduction in IQ benefit was associated with the increased risk of BPD with DHA supplementation.

13 Jun 2023

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug's effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder.

13 Jun 2023

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Metformin reduces risk of long COVID by over 40%

Researchers discuss whether metformin, ivermectin, or fluvoxamine could reduce the risk of long COVID if administered shortly after infection.

12 Jun 2023

VLA1553 vaccine candidate for chikungunya disease produces an immune response in a phase 3 trial

The VLA1553 vaccine candidate for chikungunya disease was generally well tolerated and produced an immune response in 99% (263/266) of participants, according to a phase 3 randomized controlled trial published in The Lancet.

12 Jun 2023

Common diabetes drug prevents the development of long COVID, study finds

In a new study published in The Lancet Infectious Diseases, University of Minnesota researchers found that metformin, a drug commonly used to treat diabetes, prevents the development of long COVID.

9 Jun 2023

Impact of orally administered cannabidiol (CBD) on fitness and health among healthy adult individuals

Researchers evaluated the effects of oral CBD administration on the health and fitness of healthy adults.

9 Jun 2023

First-in-class drug shows promise as a safe and effective treatment for cannabis use disorder

A first-in-class drug engineered to selectively inhibit the signaling pathway of the cannabinoid receptor shows promise as a safe and effective treatment for cannabis use disorder (CUD), a condition where a person is unable to control their cannabis use, even though it's causing problems in their lives.

8 Jun 2023

Targeted therapy for non-small cell lung cancer provides benefit to patients after surgery

A clinical trial led by Yale Cancer Center shows that the drug osimertinib, a targeted therapy for non-small cell lung cancer, improved rates of survival and reduced risk of recurrence in patients after surgery.

7 Jun 2023

Oral semaglutide outperforms other medications in type 2 diabetes treatment, significantly reducing HbA1c and body weight

Orally administered semaglutide shows significant efficacy in reducing HbA1c and body weight in patients with type 2 diabetes compared to other treatments. The study includes a large number of participants from multiple trials.

7 Jun 2023

Drinking beetroot juice every day linked to reduced risk of repeat procedures and heart attacks in angina patients with stents

Drinking beetroot juice every day for six months after having a stent fitted reduced the chance of angina patients having a heart attack or needing a repeat procedure, according to new research presented at the British Cardiovascular Society conference.

6 Jun 2023

Researchers test nitroglycerin patch as treatment for menopausal women experiencing hot flashes

Women have long searched for remedies for the bothersome hot flashes that often come with menopause.

5 Jun 2023

Flavanol consumption improves hippocampal memory function associated with cognitive aging

Researchers investigated the impact of dietary flavanols on cognitive aging.

5 Jun 2023

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

In an international study co-led by UCLA, scientists have shown that a new targeted therapy drug can extend the amount of time people with a subtype of glioma are on treatment without their cancer worsening.

4 Jun 2023

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Lupus Therapeutics announced the start of a collaboration to conduct three Phase 3 clinical trials testing an investigational therapeutic ianalumab for systemic lupus erythematosus and lupus nephritis.

2 Jun 2023

Experts voice the need for comparing traditional clinical trials to decentralized trials

There's one question that Hollings Cancer Center researcher Jennifer Dahne, Ph.D., co-director of the remote and virtual trials program at the South Carolina Clinical & Translational Research Institute, hears more than any other as she consults with clinical researchers about how to set up remote trials, also known as decentralized trials. Will these trials overcome the barriers that make it difficult for minority and underserved populations to participate in clinical trials? It's also a question she often discusses with her peers at other academic medical centers that are also home to Clinical and Translational Science Award hubs.

2 Jun 2023

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

The results of a new clinical trial suggest that the first drug therapy to slow the progression of nearsightedness in kids could be on the horizon.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

Placebo News and Research

Common laxative prucalopride may be useful as a pro-cognitive treatment in psychiatric conditions

Is the increased risk of bronchopulmonary dysplasia from high-dose docosahexaenoic acid supplementation in the neonatal period associated with changes to IQ?

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin reduces risk of long COVID by over 40%

VLA1553 vaccine candidate for chikungunya disease produces an immune response in a phase 3 trial

Common diabetes drug prevents the development of long COVID, study finds

Impact of orally administered cannabidiol (CBD) on fitness and health among healthy adult individuals

First-in-class drug shows promise as a safe and effective treatment for cannabis use disorder

Targeted therapy for non-small cell lung cancer provides benefit to patients after surgery

Oral semaglutide outperforms other medications in type 2 diabetes treatment, significantly reducing HbA1c and body weight

Drinking beetroot juice every day linked to reduced risk of repeat procedures and heart attacks in angina patients with stents

Researchers test nitroglycerin patch as treatment for menopausal women experiencing hot flashes

Flavanol consumption improves hippocampal memory function associated with cognitive aging

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Experts voice the need for comparing traditional clinical trials to decentralized trials

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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