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New drug targets EMT in cancer, reducing metastasis and resistance to chemotherapy

Metastases and resistance to chemotherapy are the main causes of treatment failure and mortality in cancer patients.

2 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

The influence of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal, and renal functions in mice

The toxic effects of aerosol exposure from electronic cigarettes (ECs) and cigarette smoke (CS) on mice.

2 Aug 2023

Study provides new insights into the intricate cellular processes driving heterotopic ossification

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation.

1 Aug 2023

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

A Penn Medicine and Children's Hospital of Philadelphia (CHOP) team will seek to develop treatments for three rare, incurable genetic diseases with the help of a $26 million grant from the National Institutes of Health (NIH).

1 Aug 2023

Investigating the neurological effects of SARS-CoV-2: anosmia and neuroinvasion as separate phenomena

A group of researchers investigated the neurotropic potential of SARS-CoV-2 and its variants by studying their ability to invade the brain through the olfactory pathway in hamsters.

1 Aug 2023

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

A recent study elucidated the molecular mechanisms of drug-induced regulation of growth differentiation factor 15 (GDF15).

1 Aug 2023

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Researchers compared the shared genetic risk and biological foundations of neurological and mental illnesses.

1 Aug 2023

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Human senescent fibroblasts trigger progressive lung fibrosis in mice."

31 Jul 2023

Researchers investigate the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma

Researchers investigated the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma.

31 Jul 2023

The essential role of the MPL36 protein in leptospirosis

The Leptospira membrane protein L36 (MPL36) is essential for its pathogenesis.

31 Jul 2023

HU3DINKS project to develop human tissue-based bioinks for 3D bioprinting

Biofabrication or 3D bioprinting aims to create tissue constructs for numerous applications including animal free testing, drug screening and regenerative medicine.

28 Jul 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.

26 Jul 2023

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

in vivo News and Research

New drug targets EMT in cancer, reducing metastasis and resistance to chemotherapy

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

The influence of electronic cigarette aerosol and cigarette smoke on cardiovascular, gastrointestinal, and renal functions in mice

Study provides new insights into the intricate cellular processes driving heterotopic ossification

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

Investigating the neurological effects of SARS-CoV-2: anosmia and neuroinvasion as separate phenomena

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

Researchers investigate the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma

The essential role of the MPL36 protein in leptospirosis

HU3DINKS project to develop human tissue-based bioinks for 3D bioprinting

New gene editing approach could revolutionize the treatment of blood disorders

Two infusions of IL-15-expressing CAR NK Cells boost survival in lymphoma mouse models

MD Anderson and Nexo Therapeutics partner to advance new cancer therapies against previously undruggable targets

Can epigenetic changes explain the strong link between age and cancer?

Tumor-derived GDF-15 suppresses immunotherapy response

Biomimetic materials pulsed with low-energy blue light can reshape damaged corneas

New technique could improve early detection of cancer metastasis

Discovery redefines current understanding of immune cell landscape in the human cornea

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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