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Study highlights the economic burden affecting individuals with sickle cell disease

In a study published today in Blood Advances, researchers found that privately insured individuals with sickle cell disease (SCD) spend approximately $1.7 million on disease-related medical expenses over their lifetime.

16 May 2022

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Researchers compared the immunogenicity of or and reactogenicity to the BNT162b2 vaccine in Japanese adults and elders.

16 May 2022

Study shows dengue virus can lower sperm production in men

A new study supports the notion that the dengue virus can be sexually transmissible for a short period after acute dengue illness and that it can also cause alterations in sperm production.

16 May 2022

Researchers help better understand the neuronal mechanisms of general anesthesia

In a paper recently published in Neuron, researchers from the group of Botond Roska at IOB reveal how different cell types in cortex change their activity during general anesthesia, helping to understand how unconsciousness may be induced.

16 May 2022

Super-antibody UT28K shows broad-spectrum activity against SARS-CoV-2 variants

A study, published online in the journal mAbs, describes a novel mAb, UT28K, that has promising broadly neutralizing activity against the SARS-CoV-2 virus.

15 May 2022

Novel approach allows islet transplants to survive and control diabetes

In type 1 diabetes, an autoimmune response attacks the pancreas's insulin-producing beta cells, leading to marked fluctuations in blood sugar levels. Lifelong daily insulin treatments are standard for patients, but replacing lost beta cells through transplants of islets, a group of cells in the pancreas, represents an attractive option.

13 May 2022

Researchers identify how the brain triages emotions during dream sleep

Researchers at the Department of Neurology of the University of Bern and University Hospital Bern identified how the brain triages emotions during dream sleep to consolidate the storage of positive emotions while dampening the consolidation of negative ones.

13 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

Novel Type 1 diabetes treatment involves pancreatic islet transplant without the need for immunosuppression

In a new study, a team of researchers from the University of Missouri, Georgia Tech and Harvard University has demonstrated the successful use of a novel Type 1 diabetes treatment in a large animal model.

13 May 2022

The potential role of the gut microbiome in modifying patient responses to statin therapy

Researchers discovered strong links between human gut microbiome makeup and statin on- and off-target effects, probably beneficial in medication tailoring.

13 May 2022

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

Islet cell transplants are a promising treatment that can cure difficult-to-treat type 1 diabetes. The cells, taken from a donor pancreas, provide patients with a sustainable and tightly controlled source of insulin.

13 May 2022

New mouse model shows the connection between stress, depression and cardiovascular disease risk

Results from a new mouse model may aid in understanding how depression and prolonged and severe stress increase the risk of cardiovascular disease, according to preliminary research presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2022.

13 May 2022

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

For the first time, researchers have successfully used bacteriophages – viruses that kill bacteria – to treat an antibiotic-resistant mycobacterial lung infection, clearing the way for a young National Jewish Health patient with cystic fibrosis to receive a life-saving lung transplant.

13 May 2022

Surprising discovery opens new avenues for in vitro organ culture

How do our cells organize themselves to give their final shape to our organs? The answer lies in morphogenesis, the set of mechanisms that regulate their distribution in space during embryonic development.

13 May 2022

Direct infection and replication of influenza virus in cardiomyocytes is a primary determinant of cardiac pathology associated with severe influenza

Researchers generated a recombinant influenza virus expressing micro ribonucleic acid (miRNAs) expressed in cardiomyocytes to infect mice, which served as a model to study the etiology of influenza-associated cardiac pathology.

13 May 2022

Antibiotics disrupt the immune system in the gut leading to fungal infection

Patients prescribed antibiotics in hospital are more likely to get fungal infections because of disruption to the immune system in the gut, according to a new study from the University of Birmingham and National Institutes of Health.

13 May 2022

Chronic obstructive pulmonary disease leads to premature senescence of the immune system

A study conducted at the University of São Paulo's Medical School (FM-USP) in Brazil, with results reported in an article published in the journal Immunity & Ageing, shows that chronic obstructive pulmonary disease (COPD) leads to premature senescence (age-related impairment) of the immune system.

13 May 2022

Collectively moving malaria parasites form vortices that are largely determined by physical principles

The disease of malaria is triggered by single-celled parasites that accumulate in large groups in the salivary glands of mosquitoes before transmission to human beings.

13 May 2022

Adolescent and young adult leukemia survivors have reduced long-term survival compared to peers without cancer

Researchers at The University of Texas MD Anderson Cancer Center have discovered that adolescent and young adult (AYA) cancer survivors of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) have reduced long-term survival rates compared to their peers without cancer.

13 May 2022

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers created polystyrene sulfonate with significantly different molar masses, constructed these polymers as an exterior around spherical gold nanoparticles of various sizes to improve multivalency effects, measured antiviral effects of the antivirals on numerous viruses in vitro, and investigated the method of interaction of the leads with SARS-CoV-2 and lentiviral particles.

13 May 2022

B Cell News and Research

Study highlights the economic burden affecting individuals with sickle cell disease

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Study shows dengue virus can lower sperm production in men

Researchers help better understand the neuronal mechanisms of general anesthesia

Super-antibody UT28K shows broad-spectrum activity against SARS-CoV-2 variants

Novel approach allows islet transplants to survive and control diabetes

Researchers identify how the brain triages emotions during dream sleep

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Novel Type 1 diabetes treatment involves pancreatic islet transplant without the need for immunosuppression

The potential role of the gut microbiome in modifying patient responses to statin therapy

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

New mouse model shows the connection between stress, depression and cardiovascular disease risk

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

Surprising discovery opens new avenues for in vitro organ culture

Direct infection and replication of influenza virus in cardiomyocytes is a primary determinant of cardiac pathology associated with severe influenza

Antibiotics disrupt the immune system in the gut leading to fungal infection

Chronic obstructive pulmonary disease leads to premature senescence of the immune system

Collectively moving malaria parasites form vortices that are largely determined by physical principles

Adolescent and young adult leukemia survivors have reduced long-term survival compared to peers without cancer

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

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