Mutation News and Research

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Transgenomic adds DFCI's Cold-PCR mutation detection technology to its portfolio

Transgenomic, Inc. (OTC Bulletin Board: TBIO). The company announced today that it has licensed a high-sensitivity mutation detection technology called Cold-PCR from the Dana-Farber Cancer Institute (DFCI), Boston, MA.

9 Oct 2009

Premature aging of immune system develops amyotrophic lateral sclerosis

Premature aging of the immune system appears to play a role in the development of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to research scientists from the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center, the Weizmann Institute of Science in Israel, and Sheba Medical Center in Israel.

9 Oct 2009

Knome incorporates HGMD information into its genome interpretation services

Knome, a recognized pioneer in the personal genomics industry, announced today that it is incorporating information from The Human Gene Mutation Database (HGMD® - Cardiff University, UK) distributed by BIOBASE, into its genome interpretation services.

8 Oct 2009

Epitope spreading can get triggered by live, attenuated Listeria vaccine

Advaxis, Inc. (OTCBB: ADXS), the live, attenuated Listeria monocytogenes (Lm) vaccine company, in collaboration with its scientific founder and Scientific Advisory Board Chair Dr. Yvonne Paterson, have shown that epitope spreading occurs in response to a form of the Company’s proprietary technology that targets tumor blood vessels (anti angiogenic antigen).

8 Oct 2009

Variation in human genomes is key to understanding inherited differences between health and disease

In research published today by Nature, an international team describes the finest map of changes to the structure of human genomes and a resource they have developed for researchers worldwide to look at the role of these changes in human disease.

8 Oct 2009

Quest Diagnostics' DNA testing for gene variants help improve outcomes for stent recipients

DNA testing for gene variants that can increase the risk of major coronary events in certain patients taking the anti-clotting drug Plavix® (clopidogrel bisulfate) is now being performed by Quest Diagnostics for Scripps Health patients electing to undergo coronary stent procedures.

From Quest Diagnostics 8 Oct 2009

BC Cancer Agency scientists find major breakthrough in breast cancer

For the first time in history, BC Cancer Agency scientists in British Columbia, Canada have decoded all of the three billion letters in the DNA sequence of a metastatic lobular breast cancer tumour, a type of breast cancer which accounts for about 10 per cent of all breast cancers, and have found all of the mutations, or "spelling" mistakes that caused the cancer to spread.

8 Oct 2009

New study to assess the risk of heart disease in diabetics

In a new international partnership, Dr. Randy Nelson, a researcher at Arizona State University's Biodesign Institute, and Dr. Tai E-Shyong , associate professor at Singapore's National University Hospital, National University Health System (NUHS), have teamed up to assess the risk of heart disease in diabetics with greater accuracy.

8 Oct 2009

Ethnicity plays a significant role in non-small cell lung cancer genetics: Study

Clinical research out of University Hospitals Case Medical Center has found that African Americans with a common form of lung cancer have a lower frequency of drug-sensitizing genetic mutations, which may impact response to new cancer-fighting drugs.

8 Oct 2009

NIH grants over $3.8 million to Asuragen

Asuragen, Inc. announced today that it has received over $3.8 million in new grant funding for 2009 from the Small Business Innovative Research (SBIR), Small Business Technology Transfer (STTR), and American Recovery and Reinvestment Act (ARRA) funded initiatives of the National Institutes of Health (NIH) to further its development of molecular diagnostics for oncology and genetic disease.

8 Oct 2009

Amarillo Biosciences, Intas Pharmaceuticals enter strategic partnership to combat influenza in India

Amarillo Biosciences, Inc. today announced that it has agreed to a strategic partnership with Intas Pharmaceuticals Limited (Intas), one of the top 20 pharmaceutical companies in India, whereby Intas will sponsor clinical trials of ABI's orally administered interferon-alpha lozenges in order to combat influenza. Intas will pay ABI a royalty on net sales after marketing approval is obtained in India.

8 Oct 2009

NHGRI awards Geospiza a SBIR grant to develop software systems for detecting rare mutations

Geospiza, Inc., the market leading developer of genetic analysis software, today announced the receipt of a Phase I SBIR grant for “Software Systems for Detecting Rare Mutations” from the National Human Genome Research Institute (1R43HG005297-01).

7 Oct 2009

Researchers validate a technique capable of quick TB diagnosis

The team headed by Doctor Manuel Casal, head of Microbiology at Reina Sofia Hospital in Cordoba has validated in patients a technique, originally produced by a German company, capable of diagnosing tuberculosis in only one day and determining whether or not it is resistant to two of the drugs used to treat this disease.

7 Oct 2009

Gene mutation linked to age-related hearing loss

Patients who exhibited a certain genetic mutation of anti-oxidant enzymes are three times more likely to develop age-related hearing loss (ARHL), according to new research presented at the 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in San Diego, CA.

7 Oct 2009

NIH awards $2 million grant to fight Neurofibromatosis type 2 disease

University of Central Florida Associate Professor Cristina Fernandez-Valle just landed two federal grants worth $2 million to research a disease that can leave children and young adults deaf, partially paralyzed or brain damaged.

6 Oct 2009

Preclinical study results of AVL-181 protease inhibitor presented

Avila Therapeutics, Inc., a biotechnology company developing novel covalent drugs that treat diseases through protein silencing, presented results of preclinical studies on its highly selective, pan-genotype, small molecule Hepatitis C Virus (HCV) protease inhibitor, AVL-181.

5 Oct 2009

Pharmacogenomics Centre deploys the Isilon IQ to accelerate its next-generation genetic sequencing operations

Isilon® Systems (Nasdaq: ISLN), the proven leader in scale-out NAS, today announced that Pharmacogenomics Centre, a partnership between Genome Quebec and the Montreal Heart Institute focused on enhancing new and existing drug development research programs through the inclusion of genetic information, has deployed Isilon IQ to accelerate its next-generation genetic sequencing operations.

5 Oct 2009

Scientists uncover the role of first-responder molecule involved in repairing DNA strand breaks

Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the Scripps Research Institute have uncovered the role played by the least-understood part of a first-responder molecule that rushes in to bind and repair breaks in DNA strands, a process that helps people avoid cancer.

5 Oct 2009

New genetic alteration can cause familial cancers

Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration - a second copy of an entire gene - is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system.

5 Oct 2009

Research study reveals primary chemotherapy benefits

Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed. With this treatment, the patients survive on average > 30 months without a recurrence. A study conducted by the Neurooncology Working Group of the German Cancer Society led by researchers from Heidelberg and Z-rich showed that patients in primary therapy benefit to the same extent from chemotherapy alone as from radiation alone.

3 Oct 2009

Mutation News and Research

Transgenomic adds DFCI's Cold-PCR mutation detection technology to its portfolio

Premature aging of immune system develops amyotrophic lateral sclerosis

Knome incorporates HGMD information into its genome interpretation services

Epitope spreading can get triggered by live, attenuated Listeria vaccine

Variation in human genomes is key to understanding inherited differences between health and disease

Quest Diagnostics' DNA testing for gene variants help improve outcomes for stent recipients

BC Cancer Agency scientists find major breakthrough in breast cancer

New study to assess the risk of heart disease in diabetics

Ethnicity plays a significant role in non-small cell lung cancer genetics: Study

NIH grants over $3.8 million to Asuragen

Amarillo Biosciences, Intas Pharmaceuticals enter strategic partnership to combat influenza in India

NHGRI awards Geospiza a SBIR grant to develop software systems for detecting rare mutations

Researchers validate a technique capable of quick TB diagnosis

Gene mutation linked to age-related hearing loss

NIH awards $2 million grant to fight Neurofibromatosis type 2 disease

Preclinical study results of AVL-181 protease inhibitor presented

Pharmacogenomics Centre deploys the Isilon IQ to accelerate its next-generation genetic sequencing operations

Scientists uncover the role of first-responder molecule involved in repairing DNA strand breaks

New genetic alteration can cause familial cancers

Research study reveals primary chemotherapy benefits

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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