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LCMC3 trial: Neoadjuvant atezolizumab prior to lung cancer surgery meets primary endpoint

(Primary analysis of the Lung Cancer Mutation Consortium (LCMC) 3 study revealed that neoadjuvant atezolizumab prior to lung cancer surgery was well tolerated by patients and met its primary endpoint of 20% major pathologic response rate, according to research presented today at the International Association for the Study of Lung Cancer's World Conference on Lung Cancer.

31 Jan 2021

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Researchers at National Taiwan University Hospital in Taipei have conducted a study demonstrating the potential effectiveness of a novel drug combination at reducing morbidity and mortality in coronavirus disease 2019 (COVID-19).

31 Jan 2021

UC Riverside mouse study resolves long-standing mystery by a whisker

When we step on the car brake upon seeing a red traffic light ahead, a sequence of events unfolds in the brain at lightning speed.

30 Jan 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

Robotic exoskeleton gait training may aid early rehabilitation for stroke

A team of New Jersey researchers has demonstrated that high-dose therapy gait training using robotic exoskeletons may aid early rehabilitation for acute stroke.

29 Jan 2021

New gene-based vaccine strategy receives grant from the Bill & Melinda Gates Foundation

The AAVCOVID vaccine program, a novel gene-based vaccine strategy that utilizes an adeno-associated virus (AAV) vector, was granted an award for up to $2.1 million from the Bill & Melinda Gates Foundation.

29 Jan 2021

Thread-based sensors can measure head movements in real time

Engineers at Tufts University have created and demonstrated flexible thread-based sensors that can measure movement of the neck, providing data on the direction, angle of rotation and degree of displacement of the head.

29 Jan 2021

SORLA protein promotes the growth of breast cancer brain metastasis

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

Kids already coping with mental disorders spiral as pandemic topples vital support systems

A bag of Doritos, that’s all Princess wanted. Her mom calls her Princess, but her real name is Lindsey. She’s 17 and lives with her mom, Sandra, a nurse, outside Atlanta.

29 Jan 2021

Scientists create new way to detect COVID-19 proteins and antibodies

Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies.

29 Jan 2021

Study: Targeting glycoprotein could improve response to cancer immunotherapy

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.

28 Jan 2021

Physicians receive Pfizer Prize for research on leukemia, cardiac arrhythmias

This year, four of a total of fifteen Pfizer Research Prizes have been awarded to physicians from the University of Bern and the Inselspital, University Hospital Bern.

28 Jan 2021

New approach to capture natural killer cells and harvest cancer-killing packets

Building on the promise of emerging therapies to deploy the body's "natural killer" immune cells to fight cancer, researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have gone one step further.

28 Jan 2021

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Scientists at the National Eye Institute have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood.

28 Jan 2021

Weight loss before surgery may not be beneficial for patients with knee osteoarthritis

A new University of Alberta study shows that losing weight before knee replacement surgery doesn't lead to better outcomes for patients.

28 Jan 2021

Insomnia patients commonly underestimate their actual sleep behavior

People with sleep disorders commonly have a misperception about their actual sleep behavior. A research group led by Karin Trimmel and Stefan Seidel from MedUni Vienna's Department of Neurology (Outpatient Clinic for Sleep Disorders and Sleep-Related Disorders) analyzed polysomnography results to identify the types of sleep disorder that are associated with a discrepancy between self-reported and objective sleep parameters and whether there are any factors that influence this.

28 Jan 2021

Fetal and neonatal therapy combination may lessen the aftereffects of congenital CMV infection

A cross-institutional research group has revealed for the first time in the world that infants with symptomatic congenital cytomegalovirus (CMV) infection who were treated with a combination of immunoglobulin fetal therapy and neonatal therapy with antiviral drugs were less likely to experience the severe aftereffects associated with the infection than those who only received the neonatal therapy.

28 Jan 2021

Variants emerging during COVID-19 pandemic resist antibody neutralization

Researchers in the U.S. have warned that recently emerged variants of SARS-CoV-2 have become worryingly resistant to monoclonal antibody therapies, plasma from convalescent patients and sera from vaccinated individuals.

28 Jan 2021

Therapy News and Research

LCMC3 trial: Neoadjuvant atezolizumab prior to lung cancer surgery meets primary endpoint

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

UC Riverside mouse study resolves long-standing mystery by a whisker

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Robotic exoskeleton gait training may aid early rehabilitation for stroke

New gene-based vaccine strategy receives grant from the Bill & Melinda Gates Foundation

Thread-based sensors can measure head movements in real time

SORLA protein promotes the growth of breast cancer brain metastasis

Kids already coping with mental disorders spiral as pandemic topples vital support systems

Scientists create new way to detect COVID-19 proteins and antibodies

Study: Targeting glycoprotein could improve response to cancer immunotherapy

Physicians receive Pfizer Prize for research on leukemia, cardiac arrhythmias

New approach to capture natural killer cells and harvest cancer-killing packets

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Weight loss before surgery may not be beneficial for patients with knee osteoarthritis

Insomnia patients commonly underestimate their actual sleep behavior

Fetal and neonatal therapy combination may lessen the aftereffects of congenital CMV infection

Variants emerging during COVID-19 pandemic resist antibody neutralization

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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