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UT Southwestern researcher measures estrogen's effect on breast cancer cells

A UT Southwestern Medical Center researcher has identified the most comprehensive measurement to date of estrogen's effect on breast cancer cells, showing for the first time how immediate and extensive the effect is.

6 May 2011

Scientists use new technologies to identify genetic cause of Kufs disease

Scientists from the Walter and Eliza Hall Institute and the University of Melbourne have used innovative new technologies to identify the gene responsible for a rare but fatal hereditary brain disorder. The discovery will make it possible to diagnose the disease through a blood test rather than a brain biopsy.

6 May 2011

Scripps Research receives CIRM grant for new research in stem cell biology and disease origins

Stem cells have huge potential in medicine because they have the ability to change or differentiate into many different cell types potentially providing a source of cells to replace those that have been permanently lost by a patient.

6 May 2011

Genome epigenetic analysis reveals new ways to detect and treat breast cancer

The most comprehensive analysis yet of the epigenetic modifications present in breast cancer has revealed potentially important new ways to detect and treat the disease, Belgian researchers have reported.

5 May 2011

BUSM research shows how heparan sulfate interacts with growth factor proteins

When the human genome project produced a map of human genes, the number of genes in humans turned out to be relatively small, approximately the same number as in primitive nematode worms.

5 May 2011

ChipDX identifies gene expression signature in early-stage breast tumors

ChipDX LLC, a New York-based molecular diagnostics and personalized medicine research company, has discovered a gene expression signature present in the cells of early-stage breast tumors that indicates the chance of the tumor recurring within 10 years.

4 May 2011

New book on the myth of junk DNA

Forty years ago scientists discovered that more than 95% of our DNA does not encode proteins. Since then the non-protein-coding portion was labeled "junk" and attributed to molecular accidents that have accumulated in the course of evolution.

4 May 2011

Researchers discover two mutations responsible for neurological condition

Mayo Clinic researchers have discovered two mutations responsible for a devastating neurological condition they first identified 15 years ago. The researchers say their study -- appearing in Nature Genetics -- has revealed a new neural pathway that may help understand a variety of similar conditions.

2 May 2011

Abnormal connections created by central nervous system linked to persistence of chronic pain

Chronic pain is an epidemic. One in four Americans suffers from chronic pain due to disease—including cancer and HIV—and the medications used to treat those diseases. One reason for the persistence of chronic pain may be that the patient's central nervous system creates abnormal connections or improves connections that shouldn't be strengthened, explains Susan G. Dorsey, PhD, RN, co-director of the School of Nursing's Center of Excellence in Disorders of Neuroregulatory Function.

30 Apr 2011

Michael Dell shows how information technology can improve efficiency, quality of care today

Michael Dell today shared his insights with healthcare executives on how information technology is being used to improve the efficiency and quality of care today and how IT can support future innovations in prevention, wellness and personalized medicine.

30 Apr 2011

Portuguese researcher to earn Bill & Melinda Gates Foundation award for new HIV therapy

João Gonçalves, from Faculdade de Farmácia e Instituto de Medicina Molecular, Lisbon, Portugal, to win a Grand Challenges Exploration Award

29 Apr 2011

Researchers develop new gene therapy technique for CGD treatment

Researchers have developed an effective technique that uses gene therapy on stem cells to correct chronic granulomatous disease in cell culture, which could eventually serve as a treatment for this rare, inherited immune disorder, according to a study published in Blood, the Journal of the American Society of Hematology.

29 Apr 2011

DNA structure co-discoverer to present 'Curing Incurable Cancer' at Uofl event

James D. Watson, Ph.D., winner of the 1962 Nobel Prize with Francis Crick and Maurice Wilkins for the discovery of the double helical structure of DNA, will present "Curing Incurable Cancer" and attend other events associated with the Kentucky Derby. Watson's appearances are sponsored by the James Graham Brown Cancer Center at the University of Louisville.

28 Apr 2011

Researchers identify three enterotypes in human intestinal bacteria

It would appear that in terms of composition, the intestinal bacteria of every individual can be divided into three main groups known as enterotypes. The intestinal bacteria in each enterotype organise themselves into distinct, stable clusters displaying common features.

28 Apr 2011

Researchers begin approved drugs screening for clinical use against rare diseases

Researchers have begun screening the first definitive collection of thousands of approved drugs for clinical use against rare and neglected diseases. They are hunting for additional uses of the drugs hoping to find off-label therapies, for some of the 6,000 rare diseases that afflict 25 million Americans.

28 Apr 2011

MIT develops new software to predict complex 3-D DNA structures

While the primary job of DNA in cells is to carry genetic information from one generation to the next, some scientists also see the highly stable and programmable molecule as an ideal building material for nanoscale structures that could be used to deliver drugs, act as biosensors, perform artificial photosynthesis and more.

28 Apr 2011

New study reveals a novel gene linked with major depression

A new study reveals a novel gene associated with major depression. The research, published by Cell Press in the April 28 issue of the journal Neuron, suggests a previously unrecognized mechanism for major depression and may guide future therapeutic strategies for this debilitating mood disorder.

28 Apr 2011